Patents by Inventor Kristian Roth
Kristian Roth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11896978Abstract: Assay cartridges are described that have purification, reaction, and detection zones and other fluidic components which can include sample chambers, waste chambers, conduits, vents, reagent chambers, reconstitution chambers and the like. The assay cartridges are used to conduct multiplexed nucleic acid measurements. Also described are kits including such cartridges, methods of using the same, and a reader configured to analyze an assay conducted using an assay cartridge.Type: GrantFiled: September 25, 2020Date of Patent: February 13, 2024Assignee: MESO SCALE TECHNOLOGIES, LLC.Inventors: Eli N. Glezer, Stephen Higgins, Sandor Kovacs, Sudeep Kumar, Kenneth Page, Kristian Roth, George Sigal
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Publication number: 20220196638Abstract: We describe apparatuses, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of liquid samples in a clinical point of care setting.Type: ApplicationFiled: December 28, 2021Publication date: June 23, 2022Applicant: Meso Scale Technologies, LLC.Inventors: Ian Chamberlin, Charles M. Clinton, Eli N. Glezer, Bandele Jeffrey-Coker, Manish Kochar, Sandor Kovacs, DT Le, Aaron Leimkuehler, Greg Pinckney, Kristian Roth, George Sigal, Fei Yin
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Publication number: 20220097072Abstract: Assay cartridges are described that have a plurality of chambers and a fluidic network that includes fluidic conduits and a multi-port valve designed to selectively connect the valve inlet and one valve outlet through a fluidic connector in the valve as the remaining valve outlets are sealed.Type: ApplicationFiled: October 1, 2021Publication date: March 31, 2022Inventors: Eli N. GLEZER, Bandele JEFFREY-COKER, Kenneth PAGE, Sandor KOVACS, Sudeep KUMAR, Kristian ROTH
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Patent number: 11135594Abstract: Assay cartridges are described that have a plurality of chambers and a fluidic network that includes fluidic conduits and a multi-port valve designed to selectively connect the valve inlet and one valve outlet through a fluidic connector in the valve as the remaining valve outlets are sealed.Type: GrantFiled: March 5, 2019Date of Patent: October 5, 2021Assignee: MESO SCALE TECHNOLOGIES, LLC.Inventors: Eli N. Glezer, Bandele Jeffrey-Coker, Kenneth Page, Sandor Kovacs, Sudeep Kumar, Kristian Roth
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Publication number: 20210060567Abstract: Assay cartridges are described that have purification, reaction, and detection zones and other fluidic components which can include sample chambers, waste chambers, conduits, vents, reagent chambers, reconstitution chambers and the like. The assay cartridges are used to conduct multiplexed nucleic acid measurements. Also described are kits including such cartridges, methods of using the same, and a reader configured to analyze an assay conducted using an assay cartridge.Type: ApplicationFiled: September 25, 2020Publication date: March 4, 2021Applicant: Meso Scale Technologies, LLC.Inventors: Eli N. Glezer, Stephen Higgins, Sandor Kovacs, Sudeep Kumar, Kenneth Page, Kristian Roth, George Sigal
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Patent number: 10814327Abstract: Assay cartridges are described that have purification, reaction, and detection zones and other fluidic components which can include sample chambers, waste chambers, conduits, vents, reagent chambers, reconstitution chambers and the like. The assay cartridges are used to conduct multiplexed nucleic acid measurements. Also described are kits including such cartridges, methods of using the same, and a reader configured to analyze an assay conducted using an assay cartridge.Type: GrantFiled: July 11, 2017Date of Patent: October 27, 2020Assignee: MESO SCALE TECHNOLOGIES, LLC.Inventors: Eli N. Glezer, Stephen Higgins, Sandor Kovacs, Sudeep Kumar, Kenneth Page, Kristian Roth, George Sigal
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Publication number: 20190201906Abstract: Assay cartridges are described that have a plurality of chambers and a fluidic network that includes fluidic conduits and a multi-port valve designed to selectively connect the valve inlet and one valve outlet through a fluidic connector in the valve as the remaining valve outlets are sealed.Type: ApplicationFiled: March 5, 2019Publication date: July 4, 2019Inventors: Eli N. Glezer, Bandele Jeffrey-Coker, Kenneth Page, Sandor Kovacs, Sudeep Kumar, Kristian Roth
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Patent number: 10272436Abstract: Assay cartridges are described that have a plurality of chambers and a fluidic network that includes fluidic conduits and a multi-port valve designed to selectively connect the valve inlet and one valve outlet through a fluidic connector in the valve as the remaining valve outlets are sealed.Type: GrantFiled: July 3, 2013Date of Patent: April 30, 2019Assignee: Meso Scale Technologies, LLC.Inventors: Eli N. Glezer, Bandele Jeffrey-Coker, Kenneth Page, Sandor Kovacs, Sudeep Kumar, Kristian Roth
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Publication number: 20170312751Abstract: Assay cartridges are described that have purification, reaction, and detection zones and other fluidic components which can include sample chambers, waste chambers, conduits, vents, reagent chambers, reconstitution chambers and the like. The assay cartridges are used to conduct multiplexed nucleic acid measurements. Also described are kits including such cartridges, methods of using the same, and a reader configured to analyze an assay conducted using an assay cartridge.Type: ApplicationFiled: July 11, 2017Publication date: November 2, 2017Applicant: Meso Scale Technologies, LLC.Inventors: Eli N. Glezer, Stephen Higgins, Sandor Kovacs, Sudeep Kumar, Kenneth Page, Kristian Roth, George Sigal
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Patent number: 9731297Abstract: Assay cartridges are described that have purification, reaction, and detection zones and other fluidic components which can include sample chambers, waste chambers, conduits, vents, reagent chambers, reconstitution chambers and the like. The assay cartridges are used to conduct multiplexed nucleic acid measurements. Also described are kits including such cartridges, methods of using the same, and a reader configured to analyze an assay conducted using an assay cartridge.Type: GrantFiled: January 5, 2012Date of Patent: August 15, 2017Assignee: MESO SCALE TECHNOLOGIES, LLC.Inventors: Eli N. Glezer, Stephen Higgins, Sandor Kovacs, Sudeep Kumar, Kenneth Page, Kristian Roth, George Sigal
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Publication number: 20150190810Abstract: Assay cartridges are described that have a plurality of chambers and a fluidic network that includes fluidic conduits and a multi-port valve designed to selectively connect the valve inlet and one valve outlet through a fluidic connector in the valve as the remaining valve outlets are sealed.Type: ApplicationFiled: July 3, 2013Publication date: July 9, 2015Inventors: Eli N. Glezer, Bandele Jeffrey-Coker, Kenneth Page, Sandor Kovacs, Sudeep Kumar, Kristian Roth
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Publication number: 20120178091Abstract: Assay cartridges are described that have purification, reaction, and detection zones and other fluidic components which can include sample chambers, waste chambers, conduits, vents, reagent chambers, reconstitution chambers and the like. The assay cartridges are used to conduct multiplexed nucleic acid measurements. Also described are kits including such cartridges, methods of using the same, and a reader configured to analyze an assay conducted using an assay cartridge.Type: ApplicationFiled: January 5, 2012Publication date: July 12, 2012Applicant: MESO SCALE TECHNOLOGIES, LLCInventors: Eli N. Glezer, Stephen Higgins, Sandor Kovacs, Sudeep Kumar, Kenneth Page, Kristian Roth, George Sigal
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Publication number: 20110143947Abstract: We describe apparatuses, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of liquid samples in a clinical point of care setting.Type: ApplicationFiled: July 27, 2010Publication date: June 16, 2011Applicant: MESO SCALE TECHNOLOGIES, LLCInventors: Ian Chamberlin, Charles M. Clinton, Eli N. Glezer, Bandele Jeffrey-Coker, Manish Kochar, Sandor Kovacs, DT Le, Aaron Leimkuehler, Greg Pinckney, Kristian Roth, George Sigal, Fei Yin
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Patent number: 7826250Abstract: This invention provides approaches to improve the signal to noise ratio (S/N) in electrochemical measurements (e.g., amperometry, voltammetry, etc.). In particular, a method is described wherein the faradaic current is temporally dissociated from the charging current associated with reading the charge of a redox-active species (e.g., a self-assembled monolayer (SAM)). This method, designated herein as open circuit potential amperometry (OCPA), quantitatively reads the charge of the redox species bound to (electrically coupled to) an electrode surface, while discriminating against both charging current(s) and amperometric signal(s) that arise, e.g., from diffusion-based species in solution.Type: GrantFiled: April 7, 2005Date of Patent: November 2, 2010Assignee: North Carolina State UniveristyInventors: Werner G. Kuhr, David F. Bocian, Jonathan S. Lindsey, Kristian A. Roth
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Publication number: 20070254141Abstract: A method for the fabrication of nanostructured semiconducting, photoconductive, photovoltaic, optoelectronic and electrical battery thin films and materials at low temperature, with no molecular template and no organic contaminants. High-quality metal oxide semiconductor, photovoltaic and optoelectronic materials can be fabricated with nanometer-scale dimensions and high dopant densities through the use of low-temperature biologically inspired synthesis routes, without the use of any biological or biochemical templates.Type: ApplicationFiled: April 18, 2007Publication date: November 1, 2007Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Daniel Morse, Birgit Schwenzer, John Gomm, Kristian Roth, Brandon Heiken, Richard Brutchey
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Publication number: 20070231794Abstract: The present invention provides a process to detect binding events on an electrode microarray. A microarray is provided having addressable electrodes and two or more different types of capture complexes at sites corresponding to the electrodes. The capture complexes capture analytes. Enzymes are attached to form a reporter complex. Substrate solutions are sequentially contacted to make enzyme products that are detectable at the electrodes by a difference in the electrical response at electrodes having the enzyme product and those not having the enzyme product. The enzyme product may be a solid deposition product. The electrical properties of electrodes on the microarray are read for the presence of the enzyme product by sequentially switching each electrode held at a constant voltage to ground and then back to the constant voltage.Type: ApplicationFiled: September 21, 2005Publication date: October 4, 2007Inventors: Kilian Dill, John Cooper, Andrei Ghindilis, Kristian Roth
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Publication number: 20070059742Abstract: Disclosed herein is a process for stripping oligonucleotide target from a microarray to allow reuse of the microarray. The process comprises providing a microarray having probe oligonucleotides attached thereto and target oligonucleotides hybridized to the probe oligonucleotides. The microarray is then incubated with a formulation comprising an organic solvent and an organic base. The target oligonucleotides are substantially removed from the microarray by the formulation. Alternatively, prior to or after incubation of the microarray with the formulation, the microarray may be contacted to an aqueous solution of a base to improve the efficiency of removal of the target oligonucleotides.Type: ApplicationFiled: August 3, 2006Publication date: March 15, 2007Inventors: Axel Stover, Andy McShea, Michael Lodes, Kristian Roth, Kevin Schwarzkopf
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Publication number: 20050185447Abstract: This invention provides approaches to improve the signal to noise ratio (S/N) in electrochemical measurements (e.g., amperometry, voltammetry, etc.). In particular, a method is described wherein the faradaic current is temporally dissociated from the charging current associated with reading the charge of a redox-active species (e.g., a self-assembled monolayer (SAM)). This method, designated herein as open circuit potential amperometry (OCPA), quantitatively reads the charge of the redox species bound to (electrically coupled to) an electrode surface, while discriminating against both charging current(s) and amperometric signal(s) that arise, e.g., from diffusion-based species in solution.Type: ApplicationFiled: April 7, 2005Publication date: August 25, 2005Inventors: Werner Kuhr, David Bocian, Jonathan Lindsey, Kristian Roth
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Patent number: 6921475Abstract: This invention provides approaches to improve the signal to noise ratio (S/N) in electrochemical measurements (e.g. amperometry, voltammetry, etc.). In particular, a method is described wherein the faradaic current is temporally dissociated from the charging current associated with reading the charge of a redox-active species (e.g. a self-assembled monolayer (SAM)). This method, designated herein as open circuit potential amperometry (OCPA), quantitatively reads the charge of the redox species bound to (electrically coupled to) an electrode surface, while discriminating against both charging current(s) and amperometric signal(s) that arise, e.g. from diffusion-based species in solution.Type: GrantFiled: March 14, 2002Date of Patent: July 26, 2005Assignee: The Regents of the University of CaliforniaInventors: Werner Kuhr, David Bocian, Jonathan S. Lindsey, Kristian A. Roth
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Publication number: 20050090634Abstract: The in vitro polymerization of silica, silicone, non-silicon metalloid-oxane and metallo-oxane polymer networks, by combining a catalyst and a substrate to polymerize the substrate to form silica, polysiloxanes, polymetalloid-oxanes polymetallo-oxanes (metal oxides), polyorganometalloid oxanes, polyorganometallo oxanes, and the polyhydrido derivatives thereof, at about neutral pH.Type: ApplicationFiled: March 22, 2004Publication date: April 28, 2005Inventors: Daniel Morse, David Kisailus, Kristian Roth