Patents by Inventor Kristin DePeaux

Kristin DePeaux has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ONCOLYTIC VIRUSES ENCODING RECOMBINANT TRANSFORMING GROWTH FACTOR (TGF)-BETA MONOMERS AND USES THEREOF
    Publication number: 20240011046
    Abstract: Oncolytic viruses encoding a recombinant form of TGF-? engineered to prevent homodimerization and recruitment of TGF-? receptor I are described. The engineered TGF-? monomers function as dominant-negative TGF-? inhibitors. Oncolytic viruses encoding a TGF-? monomer can be used for cancer immunotherapy to inhibit the immunosuppressive tumor microenvironment.
    Type: Application
    Filed: August 27, 2021
    Publication date: January 11, 2024
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Greg M. Delgoffe, Andrew P. Hinck, Kristin DePeaux