Patents by Inventor Kristin M. Listner

Kristin M. Listner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for large scale production of plasmid DNA by fermentation
    Patent number: 8603798
    Abstract: The present invention relates generally to a method for increasing the yield of plasmid DNA production. The method includes the steps of selecting a highly productive clonal subtype of a strain of E. coli, including but not limited to the DH5 strain, harboring a DNA plasmid and cultivating said clonal subtype with fed-batch fermentation in a chemically-defined medium. The plasmid DNA production process described herein can generate record quantities of plasmid DNA when said highly productive clonal subtypes are cultivated on an industrial scale. The disclosed method can be used for the production of pharmaceutical grade DNA for use in polynucleotide vaccination and gene therapy treatment regimens.
    Type: Grant
    Filed: July 25, 2011
    Date of Patent: December 10, 2013
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Michel Chartrain, Laura Kizer Bentley, Barbara Ann Krulewicz, Kristin M. Listner, Wen-jun Sun, Chanyong Brian Lee
  • PROCESS FOR LARGE SCALE PRODUCTION OF PLASMID DNA BY E. COLI FERMENTATION
    Publication number: 20120190073
    Abstract: The present invention relates generally to a method for increasing the yield of plasmid DNA production. The method includes the steps of selecting a highly productive clonal subtype of a strain of E. coli, including but not limited to the DH5 strain, harboring a DNA plasmid and cultivating said clonal subtype with fed-batch fermentation in a chemically-defined medium. The plasmid DNA production process described herein can generate record quantities of plasmid DNA when said highly productive clonal subtypes are cultivated on an industrial scale. The disclosed method can be used for the production of pharmaceutical grade DNA for use in polynucleotide vaccination and gene therapy treatment regimens.
    Type: Application
    Filed: July 25, 2011
    Publication date: July 26, 2012
    Inventors: Michel CHARTRAIN, Laura Kizer BENTLEY, Barbara Ann KRULEWICZ, Kristin M. LISTNER, Wen-jun SUN, Chanyong Brian LEE
  • Process for large scale production of plasmid DNA by fermentation
    Patent number: 7998732
    Abstract: The present invention relates generally to a method for increasing the yield of plasmid DNA production. The method includes the steps of selecting a highly productive clonal subtype of a strain of E. coli, including but not limited to the DH5 strain, harboring a DNA plasmid and cultivating said clonal subtype with fed-batch fermentation in a chemically-defined medium. The plasmid DNA production process described herein can generate record quantities of plasmid DNA when said highly productive clonal subtypes are cultivated on an industrial scale. The disclosed method can be used for the production of pharmaceutical grade DNA for use in polynucleotide vaccination and gene therapy treatment regimens.
    Type: Grant
    Filed: January 31, 2005
    Date of Patent: August 16, 2011
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Michel Chartrain, Laura Kizer Bentley, Barbara Ann Krulewicz, Kristin M. Listner, Wen-jun Sun, Chanyong Brian Lee
  • Process For Large Scale Production Of Plasmid Dna By E.Coli Fermentation
    Publication number: 20080274452
    Abstract: The present invention relates generally to a method for increasing the yield of plasmid DNA production. The method includes the steps of selecting a highly productive clonal subtype of a strain of E. coli, including but not limited to the DH5 strain, harboring a DNA plasmid and cultivating said clonal subtype with fed-batch fermentation in a chemically-defined medium. The plasmid DNA production process described herein can generate record quantities of plasmid DNA when said highly productive clonal subtypes are cultivated on an industrial scale. The disclosed method can be used for the production of pharmaceutical grade DNA for use in polynucleotide vaccination and gene therapy treatment regimens.
    Type: Application
    Filed: January 31, 2005
    Publication date: November 6, 2008
    Inventors: Michel Chartrain, Laura Kizer Bentley, Barbara Ann Krulewicz, Kristin M. Listner, Wen-jun Sun, Chanyong Brian Lee