Patents by Inventor Kristin N. Heller

Kristin N. Heller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Adeno-Associated Virus Vector Delivery of Microrna-29 to Treat Muscular Dystrophy
    Publication number: 20230001015
    Abstract: The invention provides for recombinant AAV vectors comprising a polynucleotide sequence comprising the guide strand of miR-29c and methods of using the recombinant vectors to reduce or prevent fibrosis in subjects suffering from muscular dystrophy.
    Type: Application
    Filed: April 12, 2022
    Publication date: January 5, 2023
    Inventors: Louise Rodino-Klapac, Jerry R. Mendell, Kristin N. Heller
  • Adeno-associated virus vector delivery of microRNA-29 and micro-dystrophin to treat muscular dystrophy
    Patent number: 11406717
    Abstract: The invention provides for recombinant AAV vectors comprising a polynucleotide sequence comprising the guide strand of miR-29c and methods of using the recombinant vectors to reduce or prevent fibrosis in subjects suffering from dystrophinopathy or muscular dystrophy. The invention also provides for combination therapies comprising expressing both miR-29 and micro-dystrophin to reduce and prevent fibrosis in patients suffering from dystrophinopathy or muscular dystrophy.
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: August 9, 2022
    Assignee: RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL
    Inventors: Louise Rodino-Klapac, Jerry R. Mendell, Kristin N. Heller
  • Adeno-associated virus vector delivery of microrna-29 to treat muscular dystrophy
    Patent number: 11298429
    Abstract: The invention provides for recombinant AAV vectors comprising a polynucleotide sequence comprising the guide strand of miR-29c and methods of using the recombinant vectors to reduce or prevent fibrosis in subjects suffering from muscular dystrophy.
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: April 12, 2022
    Assignee: RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL
    Inventors: Louise Rodino-Klapac, Jerry R. Mendell, Kristin N. Heller
  • ADENO-ASSOCIATED VIRUS VECTOR DELIVERY OF MICRORNA-29 TO TREAT MUSCULAR DYSTROPHY
    Publication number: 20190117795
    Abstract: The invention provides for recombinant AAV vectors comprising a polynucleotide sequence comprising the guide strand of miR-29c and methods of using the recombinant vectors to reduce or prevent fibrosis in subjects suffering from muscular dystrophy.
    Type: Application
    Filed: April 14, 2017
    Publication date: April 25, 2019
    Inventors: Louise Rodino-Klapac, Jerry R. Mendell, Kristin N. Heller
  • ADENO-ASSOCIATED VIRUS VECTOR DELIVERY OF MICRORNA-29 AND MICRO-DYSTROPHIN TO TREAT MUSCULAR DYSTROPHY
    Publication number: 20190060489
    Abstract: The invention provides for recombinant AAV vectors comprising a polynucleotide sequence comprising the guide strand of miR-29c and methods of using the recombinant vectors to reduce or prevent fibrosis in subjects suffering from dystrophinopathy or muscular dystrophy. The invention also provides for combination therapies comprising expressing both miR-29 and micro-dystrophin to reduce and prevent fibrosis in patients suffering from dystrophinopathy or muscular dystrophy.
    Type: Application
    Filed: April 14, 2017
    Publication date: February 28, 2019
    Inventors: Louise Rodino-Klapac, Jerry R. Mendell, Kristin N. Heller