Abstract: Shipping system for storing and/or transporting temperature-sensitive materials. In one embodiment, the system includes an outer box having four side walls, bottom closure flaps, and top closure flaps. A vacuum insulated panel (VIP) is detachably coupled to one of the top closure flaps and is removably covered by a cover. An insulation unit is removably positioned within the outer box, the insulation unit including a plurality of VIPs arranged to define a cavity bounded by a bottom wall and four side walls. A disposable liner assembly is removably mounted on the insulation unit. The liner assembly includes a first liner piece, a second liner piece, and a liner support. A plurality of temperature-control members and a product box may be removably positioned in a cavity defined by the liner assembly. The temperature-control members snugly fit around all sides of the product box and each include a container containing dry ice.