Patents by Inventor Kristin Ruebling-Jass
Kristin Ruebling-Jass has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220275112Abstract: An enzymatically produced soluble ?-glucan fiber composition is provided suitable for use as a digestion resistant fiber in food and feed applications. The soluble ?-glucan fiber composition can be blended with one or more additional food ingredients to produce fiber-containing compositions. Methods for the production and use of compositions comprising the soluble ?-glucan fiber are also provided.Type: ApplicationFiled: February 25, 2022Publication date: September 1, 2022Inventors: Qiong Cheng, Robert DiCosimo, Arthur Ouwehand, Zheng You, Mark S. Payne, Jian Ping Lai, Kristin Ruebling-Jass, Steven Cary Rothman
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Patent number: 11312968Abstract: Strains of yeast genetically engineered to produce increased amounts of non-hydroxylated collagen or hydroxylated collagen are described. An all-in-one vector including the DNA necessary to produce collagen, promotors, and hydroxylating enzymes is also described. Methods for producing non-hydroxylated or hydroxylated collagen are also provided.Type: GrantFiled: June 29, 2018Date of Patent: April 26, 2022Assignee: MODERN MEADOW, INC.Inventors: Lixin Dai, Julia Borden, Jeffrey Nelson, Kristin Ruebling-Jass
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Patent number: 11261264Abstract: An enzymatically produced soluble ?-glucan fiber composition is provided suitable for use as a digestion resistant fiber in food and feed applications. The soluble ?-glucan fiber composition can be blended with one or more additional food ingredients to produce fiber-containing compositions. Methods for the production and use of compositions comprising the soluble ?-glucan fiber are also provided.Type: GrantFiled: June 25, 2019Date of Patent: March 1, 2022Assignee: NUTRITION & BIOSCIENCES USA 4, INC.Inventors: Qiong Cheng, Robert DiCosimo, Arthur Ouwehand, Zheng You, Mark S. Payne, Jian Ping Lai, Kristin Ruebling-Jass, Steven Cary Rothman
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Patent number: 11028146Abstract: This invention relates to genetically engineered strains of yeast and methods for producing recombinant protein (e.g., collagen). Recombinant protein of the present invention is used to produce biofabricated leather or a material having leather-like properties containing recombinant or engineered collagen. The yeast strains are engineered to produce ascorbate and/or increased production of ? ketoglutarate.Type: GrantFiled: September 7, 2018Date of Patent: June 8, 2021Assignee: MODERN MEADOW, INC.Inventors: Lixin Dai, Kristin Ruebling-Jass, David Thomas Williamson
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Publication number: 20190389978Abstract: An enzymatically produced soluble ?-glucan fiber composition is provided suitable for use as a digestion resistant fiber in food and feed applications. The soluble ?-glucan fiber composition can be blended with one or more additional food ingredients to produce fiber-containing compositions. Methods for the production and use of compositions comprising the soluble ?-glucan fiber are also provided.Type: ApplicationFiled: June 25, 2019Publication date: December 26, 2019Inventors: Qiong Cheng, Robert DiCosimo, Arthur Ouwehand, Zheng You, Mark S. Payne, Jian Ping Lai, Kristin Ruebling-Jass, Steven Cary Rothman
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Patent number: 10351633Abstract: An enzymatically produced soluble ?-glucan fiber composition is provided suitable for use as a digestion resistant fiber in food and feed applications. The soluble ?-glucan fiber composition can be blended with one or more additional food ingredients to produce fiber-containing compositions. Methods for the production and use of compositions comprising the soluble ?-glucan fiber are also provided.Type: GrantFiled: May 22, 2015Date of Patent: July 16, 2019Assignee: E I DU PONT DE NEMOURS AND COMPANYInventors: Qiong Cheng, Robert Dicosimo, Arthur Ouwehand, Zheng You, Mark S. Payne, Jian Ping Lai, Kristin Ruebling-Jass, Steven Cary Rothman
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Publication number: 20190093116Abstract: This invention relates to genetically engineered strains of yeast and methods, for producing recombinant protein (e.g., collagen). Recombinant protein of the present invention is used to produce biofabricated leather or a material having leather-like properties containing recombinant or engineered collagen. The yeast strains are engineered to produce ascorbate and/or increased production of ? ketoglutarate.Type: ApplicationFiled: September 7, 2018Publication date: March 28, 2019Applicant: MODERN MEADOW, INC.Inventors: Lixin Dai, Kristin Ruebling-Jass, David Thomas Williamson
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Publication number: 20190040400Abstract: Strains of yeast genetically engineered to produce increased amounts of non-hydroxylated collagen or hydroxylated collagen are described. A chimeric collagen DNA sequence, comprising from 10 to 40 percent or 60 to 90 percent of optimized DNA based on the total length of the chimeric collagen DN. An all-in-one vector including the DNA necessary to produce collagen, promotors, and hydroxylating enzymes is also described. Methods for producing non-hydroxylated or hydroxylated collagen are also provided.Type: ApplicationFiled: July 30, 2018Publication date: February 7, 2019Applicant: MODERN MEADOW, INC.Inventors: Lixin DAI, Julia BORDEN, Jeffrey NELSON, Kristin RUEBLING-JASS
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Publication number: 20190002893Abstract: Strains of yeast genetically engineered to produce increased amounts of non-hydroxylated collagen or hydroxylated collagen are described. An all-in-one vector including the DNA necessary to produce collagen, promotors, and hydroxylating enzymes is also described. Methods for producing non-hydroxylated or hydroxylated collagen are also provided.Type: ApplicationFiled: June 29, 2018Publication date: January 3, 2019Applicant: MODERN MEADOW, INC.Inventors: Lixin Dai, Julia Borden, Jeffrey Nelson, Kristin Ruebling-Jass
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Publication number: 20170218093Abstract: An enzymatically produced soluble ?-glucan fiber composition is provided suitable for use as a digestion resistant fiber in food and feed applications. The soluble ?-glucan fiber composition can be blended with one or more additional food ingredients to produce fiber-containing compositions. Methods for the production and use of compositions comprising the soluble ?-glucan fiber are also provided.Type: ApplicationFiled: May 22, 2015Publication date: August 3, 2017Inventors: Qiong Cheng, Robert Dicosimo, Arthur Ouwehand, Zheng You, Mark S. Payne, Jian Ping Lai, Kristin Ruebling-Jass, Steven Cary Rothman
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Publication number: 20170198322Abstract: An enzymatically produced soluble ?-glucan fiber composition is provided suitable for use as a digestion resistant fiber in food and feed applications. The soluble ?-glucan fiber composition can be blended with one or more additional food ingredients to produce fiber-containing compositions. Methods for the production and use of compositions comprising the soluble ?-glucan fiber are also provided.Type: ApplicationFiled: May 22, 2015Publication date: July 13, 2017Inventors: Qiong Cheng, Robert Dicosimo, Andrew C. Eliot, Arthur Ouwehand, Brian Michael Roesch, Steven Cary Rothman, Kristin Ruebling-Jass, Zheng You
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Patent number: 9273336Abstract: Methods are provided to obtain recombinant microbial cells having at least one genetic modification that increase the buoyant density of a recombinant microbial cell or the buoyant density of inclusion bodies produced within a recombinant microbial cell. Exemplified are genetic modifications that increase the buoyant density of a recombinant microbial cell expressing heterologous peptides and polypeptides. Increasing expression of the genes ysaB, glyQ, glyS or a combination thereof within the recombinant microbial cell produces cells or inclusion bodies having higher buoyant density. A similar effect was achieved by decreasing or disrupting expression of the endogenous gltA gene. Increases in buoyant density render peptide production more efficient with respect to time and costs.Type: GrantFiled: June 21, 2011Date of Patent: March 1, 2016Assignee: E. I. du Pont de Nemours and CompanyInventors: Ritu Bhalla, Qi Chen, Qiong Cheng, Neeraj Pandey, Pierre E. Rouviere, Kristin Ruebling-Jass, Annapurna Sachan
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Publication number: 20150203876Abstract: Recombinant bacteria capable of metabolizing sucrose are described. The recombinant bacteria comprise in their genome or on at least one recombinant construct, a novel nucleotide sequence encoding a polypeptide having sucrose transporter activity and a nucleotide sequence encoding a polypeptide having sucrose hydrolase activity. These nucleotide sequences are each operably linked to the same or a different promoter. Recombinant bacteria capable of metabolizing sucrose to produce glycerol and/or glycerol-derived products such as 1,3-propanediol and 3-hydroxypropionic acid are also described.Type: ApplicationFiled: April 1, 2015Publication date: July 23, 2015Applicant: E.I. DU PONT DE NEMOURS AND COMPANYInventors: Kristin RUEBLING-JASS, Jean-Francois TOMB, Tina K. VAN DYK, Zheng YOU
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Patent number: 9017961Abstract: Recombinant bacteria capable of metabolizing sucrose are described. The recombinant bacteria comprise in their genome or on at least one recombinant construct, a novel nucleotide sequence encoding a polypeptide having sucrose transporter activity and a nucleotide sequence encoding a polypeptide having sucrose hydrolase activity. These nucleotide sequences are each operably linked to the same or a different promoter. Recombinant bacteria capable of metabolizing sucrose to produce glycerol and/or glycerol-derived products such as 1,3-propanediol and 3-hydroxypropionic acid are also described.Type: GrantFiled: March 5, 2012Date of Patent: April 28, 2015Assignee: E.I. du Pont de Nemours and CompanyInventors: Kristin Ruebling-Jass, Jean-Francois Tomb, Tina K Van Dyk, Zheng You
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Publication number: 20150064755Abstract: Recombinant bacteria capable of metabolizing sucrose are described. The recombinant bacteria comprise in their genome or on at least one recombinant construct, a novel nucleotide sequence encoding a polypeptide having sucrose transporter activity and a nucleotide sequence encoding a polypeptide having sucrose hydrolase activity. These nucleotide sequences are each operably linked to the same or a different promoter. Recombinant bacteria capable of metabolizing sucrose to produce glycerol and/or glycerol-derived products such as 1,3-propanediol and 3-hydroxypropionic acid are also described.Type: ApplicationFiled: March 5, 2013Publication date: March 5, 2015Applicant: E I DU PONT DE NEMOURS AND COMPANYInventors: Kristin Ruebling-Jass, Jean-Francois Tomb, Tina K Van Dyk, Zheng You
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Publication number: 20140093927Abstract: Variant sucrose transporter polypeptides that enable faster sucrose utilization in bacteria are described. Additionally, variant or recombinant bacteria comprising these variant sucrose transporter polypeptides, and methods of utilizing the bacteria to produce products such as glycerol and glycerol-derived products are provided.Type: ApplicationFiled: December 5, 2013Publication date: April 3, 2014Applicant: E. I. du Pont de Nemours and CompanyInventors: Qi CHEN, Qiong CHENG, Jian Ping LAI, Kristin RUEBLING-JASS
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Patent number: 8673602Abstract: Recombinant bacteria having an improved ability to utilize sucrose are provided. These recombinant bacteria have nucleotide sequences encoding sucrose utilization polypeptides integrated into their genome between the yihP gene or its homolog and the yihO gene or its homolog. Additionally, methods of utilizing the recombinant bacteria to produce products such as glycerol and glycerol-derived products are provided.Type: GrantFiled: August 16, 2011Date of Patent: March 18, 2014Assignee: E I du Pont de Nemours and CompanyInventors: Qi Chen, Qiong Cheng, Jian Ping Lai, Kristin Ruebling-Jass
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Patent number: 8629243Abstract: Variant sucrose transporter polypeptides that enable faster sucrose utilization in bacteria are described. Additionally, variant or recombinant bacteria comprising these variant sucrose transporter polypeptides, and methods of utilizing the bacteria to produce products such as glycerol and glycerol-derived products are provided.Type: GrantFiled: August 16, 2011Date of Patent: January 14, 2014Assignee: E I du Pont de Nemours and CompanyInventors: Qi Chen, Qiong Cheng, Jian Ping Lai, Kristin Ruebling-Jass
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Publication number: 20130230893Abstract: Recombinant bacteria capable of metabolizing sucrose are described. The recombinant bacteria comprise in their genome or on at least one recombinant construct, a novel nucleotide sequence encoding a polypeptide having sucrose transporter activity and a nucleotide sequence encoding a polypeptide having sucrose hydrolase activity. These nucleotide sequences are each operably linked to the same or a different promoter. Recombinant bacteria capable of metabolizing sucrose to produce glycerol and/or glycerol-derived products such as 1,3-propanediol and 3-hydroxypropionic acid are also described.Type: ApplicationFiled: March 5, 2012Publication date: September 5, 2013Applicant: E I DU PONT DE NEMOURS AND COMPANYInventors: KRISTIN RUEBLING-JASS, Jean-Francois Tomb, Tina K. Van Dyk, Zheng You
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Publication number: 20130045518Abstract: Variant sucrose transporter polypeptides that enable faster sucrose utilization in bacteria are described. Additionally, variant or recombinant bacteria comprising these variant sucrose transporter polypeptides, and methods of utilizing the bacteria to produce products such as glycerol and glycerol-derived products are provided.Type: ApplicationFiled: August 16, 2011Publication date: February 21, 2013Applicant: E. I. DU PONT DE NEMOURS AND COMPANYInventors: QI Chen, Qiong Cheng, Jian Ping Lai, Kristin Ruebling-Jass