Patents by Inventor Kristin Weidemaier
Kristin Weidemaier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11344851Abstract: A biological fluid separation device adapted to receive a biological fluid sample having a first portion and a second portion is disclosed. The device includes a housing having a first chamber having a first chamber inlet for receiving the biological fluid sample therein and a first chamber outlet. The housing has a second chamber having a second chamber inlet and a second chamber outlet, and a separation member separating at least a portion of the first chamber outlet and the second chamber. The separation member is adapted to restrain the first portion of the biological fluid sample within the first chamber and to allow at least a portion of the second portion of the biological fluid sample to pass into the second chamber. An actuator, such as a vacuum source, draws the biological fluid sample into the first chamber and the second portion into the second chamber.Type: GrantFiled: October 21, 2019Date of Patent: May 31, 2022Assignee: BECTON, DICKINSON AND COMPANYInventors: Qihua Xu, Kristin Weidemaier, Christopher Basciano, Sivaramakrishnan Balasubramanian, Patrick Downie
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Patent number: 11305241Abstract: A biological fluid separation device adapted to receive a biological fluid sample having a first portion and a second portion is disclosed. The device includes a housing having a first chamber having a first chamber inlet for receiving the biological fluid sample therein and a first chamber outlet. The housing has a second chamber having a second chamber inlet and a second chamber outlet, and a separation member separating at least a portion of the first chamber outlet and the second chamber. The separation member is adapted to restrain the first portion of the biological fluid sample within the first chamber and to allow at least a portion of the second portion of the biological fluid sample to pass into the second chamber. An actuator, such as a vacuum source, draws the biological fluid sample into the first chamber and the second portion into the second chamber.Type: GrantFiled: October 21, 2019Date of Patent: April 19, 2022Assignee: BECTON, DICKINSON AND COMPANYInventors: Qihua Xu, Kristin Weidemaier, Christopher Basciano, Sivaramakrishnan Balasubramanian, Patrick Downie
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Publication number: 20220074831Abstract: Methods and apparatus provide filtration for concentrating analytes, such as bacteria or exosomes, of a biological sample, such as blood or urine. The technology may employ membrane devices that implement one or more tangential flow filtration processes such as in stages. An example membrane device may typically include a membrane having sides and ends. The membrane may selectively permit constituent(s) of the sample to pass through while retaining other constituents at one side. An input chamber of the device may include an inlet near one end and an outlet near the other end, and that may permit a tangential flow of the sample along the first side surface, and a trans-membrane passing of constituent(s). An output chamber of the device may be configured at the second side surface to receive the passing constituents. Such devices may be provided in a kit to facilitate targeting of a desired biological analyte concentration.Type: ApplicationFiled: January 23, 2020Publication date: March 10, 2022Applicant: BECTON DICKINSON AND COMPANYInventors: Qihua Xu, Kristin Weidemaier, Jon E. Salomon, Alexander G. Lastovich, Eric A. Fallows, Sean Connell, Joshua Herr, Meghan Wolfgang, Michael A. Brasch, Richard L. Moore, David S. Sebba, Cristian Clavijo, Shirley Ng, Richard Abbott, Alexander Adam Papp, Henry Li-Wei Fu, Caitlin Marie Austin, Sean Patrick Dowling, Owen Lewis Joyce, Michael L. Kiplinger, William Kevin Carpenter
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Publication number: 20210378567Abstract: A blood separation device that allows high quality plasma to be generated using a single power source. The device includes a housing with an inlet port adapted to receive the blood sample, a first chamber having a first chamber flow channel in fluid communication with the inlet port, a second chamber having a second chamber flow channel, a separation member disposed between the first chamber and the second chamber. In some embodiments, the blood separation device detects or tests for the presence of a substance, such as an antigen or an antibody.Type: ApplicationFiled: June 7, 2021Publication date: December 9, 2021Applicant: BECTON DICKINSON AND COMPANYInventors: Kristin Weidemaier, Alexander G. Lastovich, Qihua Xu, Richard Abbott
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Publication number: 20210164015Abstract: Provided herein are compositions, methods, systems and/or kits for measuring microbial viability in a sample. Certain embodiments of the present disclosure are related to detection tests comprising compositions, methods, systems and/or kits for measuring an antimicrobial minimum inhibitory concentration and for measuring microbial susceptibility to the antimicrobial. Certain embodiments of the present disclosure are related to detection tests comprising compositions, methods, systems and/or kits for assessing microbial proliferation in a sample.Type: ApplicationFiled: February 9, 2021Publication date: June 3, 2021Inventors: Kristin Weidemaier, David Sebba, Rajendra Bhat, Meghan Wolfgang, Pauline Bell
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Patent number: 11016095Abstract: Disclosed herein are diagnostic assays using surface enhanced Raman spectroscopy (SERS)-active particles, including liquid-based assays; magnetic capture assays; microparticle-nanoparticle satellite structures for signal amplification in an assay; composite SERS-active particles useful for enhanced detection of targets; and sample tubes and processes for using the same.Type: GrantFiled: September 22, 2017Date of Patent: May 25, 2021Assignee: BECTON DICKINSON AND COMPANYInventors: Kristin Weidemaier, Christian Sandmann, William Shannon Dillmore, James L. Schram, W. William Stewart, Robert E. Pearson, Helen Hsieh, Steven Keith, Rajendra R. Bhat, Andrea Liebmann-Vinson, Adam Craig Curry, Alexander G. Lastovich
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Patent number: 10962533Abstract: Provided herein are methods, systems, and devices for detecting and/or identifying one or more specific microorganisms in a culture sample. Indicator particles, such as surface enhanced Raman spectroscopy (SERS)-active nanoparticles, each having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest, can form a complex with specific microorganisms in the culture sample. Further, agitating magnetic capture particles also having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest can be used to capture the microorganism-indicator particle complex and concentrate the complex in a localized area of an assay vessel for subsequent detection and identification. The complex can be dispersed, pelleted, and redispersed so that the culture sample can be retested a number of times during incubation so as to allow for real-time monitoring of the culture sample.Type: GrantFiled: November 27, 2017Date of Patent: March 30, 2021Assignee: BECTON, DICKINSON AND COMPANYInventors: Kristin Weidemaier, Erin Gooch Carruthers, Adam C. Curry, Melody M. H. Kuroda, Ammon David Lentz, Michael Justin Lizzi, Eric A. Fallows, Donald E. Gorelick, Jack Kessler, Spencer Lovette, Jeffrey S. Ojala, Mark A. Talmer
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Publication number: 20200047134Abstract: A biological fluid separation device adapted to receive a biological fluid sample having a first portion and a second portion is disclosed. The device includes a housing having a first chamber having a first chamber inlet for receiving the biological fluid sample therein and a first chamber outlet. The housing has a second chamber having a second chamber inlet and a second chamber outlet, and a separation member separating at least a portion of the first chamber outlet and the second chamber. The separation member is adapted to restrain the first portion of the biological fluid sample within the first chamber and to allow at least a portion of the second portion of the biological fluid sample to pass into the second chamber. An actuator, such as a vacuum source, draws the biological fluid sample into the first chamber and the second portion into the second chamber.Type: ApplicationFiled: October 21, 2019Publication date: February 13, 2020Inventors: Qihua Xu, Kristin Weidemaier, Christopher Basciano, Sivaramakrishnan Balasubramanian, Patrick Downie
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Patent number: 10493409Abstract: A biological fluid separation device adapted to receive a biological fluid sample having a first portion and a second portion is disclosed. The device includes a housing having a first chamber having a first chamber inlet for receiving the biological fluid sample therein and a first chamber outlet. The housing has a second chamber having a second chamber inlet and a second chamber outlet, and a separation member separating at least a portion of the first chamber outlet and the second chamber. The separation member is adapted to restrain the first portion of the biological fluid sample within the first chamber and to allow at least a portion of the second portion of the biological fluid sample to pass into the second chamber. An actuator, such as a vacuum source, draws the biological fluid sample into the first chamber and the second portion into the second chamber.Type: GrantFiled: March 2, 2017Date of Patent: December 3, 2019Assignee: Becton, Dickinson and CompanyInventors: Qihua Xu, Kristin Weidemaier, Christopher Basciano, Sivaramakrishnan Balasubramanian, Patrick Downie
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Publication number: 20180136204Abstract: Provided herein are methods, systems, and devices for detecting and/or identifying one or more specific microorganisms in a culture sample. Indicator particles, such as surface enhanced Raman spectroscopy (SERS)-active nanoparticles, each having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest, can form a complex with specific microorganisms in the culture sample. Further, agitating magnetic capture particles also having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest can be used to capture the microorganism-indicator particle complex and concentrate the complex in a localized area of an assay vessel for subsequent detection and identification. The complex can be dispersed, pelleted, and redispersed so that the culture sample can be retested a number of times during incubation so as to allow for real-time monitoring of the culture sample.Type: ApplicationFiled: November 27, 2017Publication date: May 17, 2018Applicant: BECTON DICKINSON AND COMPANYInventors: Kristin Weidemaier, Robert L. Campbell, Erin Gooch Carruthers, Adam Craig Curry, Kevin G. Dolan, Andrea Liebmann-Vinson, Wendy Dale Woodley, Melody M.H. Kuroda, Ammon David Lentz, Dwight Livingston, Michael Justin Lizzi, Artis R. Lockhart, Ernie Ritchey, Eric A. Fallows, Donald E. Gorelick, Jack Kessler, Spencer Lovette, Jeffrey S. Ojala, Mark A. Talmer, Miroslaw Bartkowiak, Scott N. Danhof, Gregory S. Kramer, Thomas D. Haubert, Michael L. Marshall, James A. Prescott, Randy J. Somerville, M. Scott Ulrich, David S. Sebba
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Publication number: 20180059118Abstract: Disclosed herein are diagnostic assays using surface enhanced Raman spectroscopy (SERS)-active particles, including liquid-based assays; magnetic capture assays; microparticle-nanoparticle satellite structures for signal amplification in an assay; composite SERS-active particles useful for enhanced detection of targets; and sample tubes and processes for using the same.Type: ApplicationFiled: September 22, 2017Publication date: March 1, 2018Applicant: BECTON DICKINSON AND COMPANYInventors: Kristin Weidemaier, Christian Sandmann, William Shannon Dillmore, James L. Schram, W. William Stewart, Robert E. Pearson, Helen Hsieh, Steven Keith, Rajendra R. Bhat, Andrea Liebmann-Vinson, Adam Craig Curry, Alexander G. Lastovich
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Patent number: 9874555Abstract: Provided herein are methods, systems, and devices for detecting and/or identifying one or more specific microorganisms in a culture sample. Indicator particles, such as surface enhanced Raman spectroscopy (SERS)-active nanoparticles, each having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest, can form a complex with specific microorganisms in the culture sample. Further, agitating magnetic capture particles also having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest can be used to capture the microorganism-indicator particle complex and concentrate the complex in a localized area of an assay vessel for subsequent detection and identification. The complex can be dispersed, pelleted, and redispersed so that the culture sample can be retested a number of times during incubation so as to allow for real-time monitoring of the culture sample.Type: GrantFiled: March 15, 2013Date of Patent: January 23, 2018Assignee: BECTON, DICKINSON AND COMPANYInventors: Kristin Weidemaier, Robert L. Campbell, Erin Gooch Carruthers, Adam C. Curry, Kevin G. Dolan, Andrea Liebmann-Vinson, Wendy Dale Woodley, Melody M. H. Kuroda, Eric A. Fallows, Miroslaw Bartkowiak, Scott N. Danhof, Gregory S. Kramer, Thomas D. Haubert, Michael L. Marshall, James A. Prescott, Randy J. Somerville, M. Scott Ulrich, David S. Sebba
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Patent number: 9823253Abstract: Disclosed herein are diagnostic assays using surface enhanced Raman spectroscopy (SERS)-active particles, including liquid-based assays; magnetic capture assays; microparticle-nanoparticle satellite structures for signal amplification in an assay; composite SERS-active particles useful for enhanced detection of targets; and sample tubes and processes for using the same.Type: GrantFiled: March 20, 2008Date of Patent: November 21, 2017Assignee: Becton, Dickinson and CompanyInventors: Kristin Weidemaier, Christian Sandmann, W. Shannon Dillmore, James L. Schram, W. William Stewart, Robert E. Pearson, Helen Hsieh, Steven Keith, Rajendra R. Bhat, Andrea Liebmann-Vinson, Adam Craig Curry, Alexander G. Lastovich
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Publication number: 20170252706Abstract: A biological fluid separation device adapted to receive a biological fluid sample having a first portion and a second portion is disclosed. The device includes a housing having a first chamber having a first chamber inlet for receiving the biological fluid sample therein and a first chamber outlet. The housing has a second chamber having a second chamber inlet and a second chamber outlet, and a separation member separating at least a portion of the first chamber outlet and the second chamber. The separation member is adapted to restrain the first portion of the biological fluid sample within the first chamber and to allow at least a portion of the second portion of the biological fluid sample to pass into the second chamber. An actuator, such as a vacuum source, draws the biological fluid sample into the first chamber and the second portion into the second chamber.Type: ApplicationFiled: March 2, 2017Publication date: September 7, 2017Inventors: Qihua Xu, Kristin Weidemaier, Christopher Basciano, Sivaramakrishnan Balasubramanian, Patrick Downie
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Publication number: 20170233787Abstract: Methods and compositions for the detection of glucose-6-phosphate dehydrogenase (G6PD) enzyme activity in blood samples are described. Some embodiments disclosed herein provide methods for detecting G6PD activity in undiluted or minimally diluted blood samples, including obtaining a blood sample, and detecting G6PD activity present in the undiluted or minimally diluted blood sample by epifluorescence. Also provided are methods for detecting G6PD activity and detecting a bloodborne microorganism as two parts of a single test.Type: ApplicationFiled: August 4, 2015Publication date: August 17, 2017Inventors: David Sebba, Adam Curry, Kara Birchfield, Kristin Weidemaier, Erin Carruthers
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Publication number: 20150118688Abstract: Provided herein are methods, systems, and devices for detecting and/or identifying one or more specific microorganisms in a culture sample. Indicator particles, such as surface enhanced Raman spectroscopy (SERS)-active nanoparticles, each having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest, can form a complex with specific microorganisms in the culture sample. Further, agitating magnetic capture particles also having associated therewith one or more specific binding members having an affinity for the one or more microorganisms of interest can be used to capture the microorganism-indicator particle complex and concentrate the complex in a localized area of an assay vessel for subsequent detection and identification. The complex can be dispersed, pelleted, and redispersed so that the culture sample can be retested a number of times during incubation so as to allow for real-time monitoring of the culture sample.Type: ApplicationFiled: March 15, 2013Publication date: April 30, 2015Inventors: Kristin Weidemaier, Robert L. Campbell, Erin Gooch Carruthers, Adam C. Curry, Kevin G. Dolan, Andrea Liebmann-Vinson, Wendy Dale Woodley, Melody M.H. Kuroda, Ammon David Lentz, Dwight Livingston, Michael Justin Lizzi, Artis R. Lockhart, Ernie Ritchey, Eric A. Fallows, Donald E. Gorelick, Jack Kessler, Spencer Lovette, Jeffrey S. Ojala, Mark A. Talmer, Miroslaw Bartkowiak, Scott N. Danhof, Gregory S. Kramer, Thomas D. Haubert, Michael L. Marshall, James A. Prescott, Randy J. Somerville, M. Scott Ulrich, David S. Sebba
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Publication number: 20150018641Abstract: A device for sensing analyte concentration, and in particular glucose concentration, in vivo or in vitro is disclosed. A sensing element is attached to the distal end of an optical conduit, and comprises at least one binding protein adapted to bind with at least one target analyte. The sensing element further comprises at least one reporter group that undergoes a luminescence change with changing analyte concentrations. Optionally, the optical conduit and sensing element may be housed within a cannulated bevel.Type: ApplicationFiled: July 1, 2013Publication date: January 15, 2015Applicant: Becton, Dickinson and CompanyInventors: Javier Alarcon, Kristin Weidemaier, Terry J. Amiss, John D. DeNuzzio, Christopher C. Herdman, Ross W. Jacobson, J. Bruce Pitner, Douglas B. Sherman
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Publication number: 20130281310Abstract: Coated nanoparticles comprising a core surrounded by a shell that increases the reflectance of the nanoparticle, wherein the coated nanoparticle does not include a Raman-active molecule, are provided. Test devices and immunoassay methods utilizing the coated nanoparticles are provided.Type: ApplicationFiled: October 25, 2012Publication date: October 24, 2013Inventors: Kristin Weidemaier, Melody Kuroda, Christian Sandmann, Lori Pederson Allphin, Adam C. Curry, Robert A. Fulcher
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Publication number: 20110275061Abstract: Disclosed herein are diagnostic assays using surface enhanced Raman spectroscopy (SERS)-active particles, including liquid-based assays; magnetic capture assays; microparticle-nanoparticle satellite structures for signal amplification in an assay; composite SERS-active particles useful for enhanced detection of targets; and sample tubes and processes for using the same.Type: ApplicationFiled: March 20, 2008Publication date: November 10, 2011Inventors: Kristin Weidemaier, Christian Sandmann, W. Shannon Dillmore, James L. Schram, W. William Stewart, Robert E. Pearson, Helen Hsieh, Steven Keith, Rajendra R. Bhat, Andrea Liebmann-Vinson, Adam Craig Curry, Alexander G. Lastovich
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Publication number: 20110184259Abstract: A device for sensing analyte concentration, and in particular glucose concentration, in vivo or in vitro is disclosed. A sensing element is attached to the distal end of an optical conduit, and comprises at least one binding protein adapted to bind with at least one target analyte. The sensing element further comprises at least one reporter group that undergoes a luminescence change with changing analyte concentrations. Optionally, the optical conduit and sensing element may be housed within a cannulated bevel.Type: ApplicationFiled: August 23, 2010Publication date: July 28, 2011Inventors: Javier Alarcon, Kristin Weidemaier, Terry J. Amiss, John D. DeNuzzio, Christopher C. Herdman, Ross W. Jacobson, J. Bruce Pitner, Douglas B. Sherman, Steven Keith