Patents by Inventor Kristina Lemonidis Tarbet

Kristina Lemonidis Tarbet has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTISENSE MODULATION OF ACYL COA CHOLESTEROL ACYLTRANSFERASE-2 EXPRESSION
    Publication number: 20100197764
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of acyl CoA cholesterol acyltransferase-2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding acyl CoA cholesterol acyltransferase-2. Methods of using these compounds for modulation of acyl CoA cholesterol acyltransferase-2 expression and for treatment of diseases associated with expression of acyl CoA cholesterol acyltransferase-2 are provided.
    Type: Application
    Filed: December 30, 2009
    Publication date: August 5, 2010
    Applicant: Isis Pharmaceuticals, Inc.
    Inventors: Rosanne M. Crooke, Kristina Lemonidis Tarbet, Mark J. Graham
  • METHODS FOR TREATING HYPERCHOLESTEROLEMIA
    Publication number: 20100144834
    Abstract: Disclosed herein are antisense compounds and methods for decreasing LDL-C in an individual having elevated LDL-C. Additionally disclosed are antisense compounds and methods for treating hypercholesterolemia, or alternatively for treating or preventing atherosclerosis. Further disclosed are antisense compounds and methods for decreasing coronary heart disease risk. Such methods include administering to an individual in need of treatment an antisense compound targeted to a PCSK9 nucleic acid. The antisense compounds administered include gapmer antisense oligonucleotides.
    Type: Application
    Filed: November 27, 2007
    Publication date: June 10, 2010
    Applicant: ISIS PHARMACEUTICALS, INC.
    Inventors: Susan M. Freier, Rosanne M. Crooke, Mark J. Graham, Kristina Lemonidis Tarbet, Sanjay Bhanot, Diane Tribble, Andrew T. Watts
  • ANTISENSE MODULATION OF ACYL COA CHOLESTEROL ACYLTRANSFERASE-2 EXPRESSION
    Publication number: 20080182810
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of acyl CoA cholesterol acyltransferase-2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding acyl CoA cholesterol acyltransferase-2. Methods of using these compounds for modulation of acyl CoA cholesterol acyltransferase-2 expression and for treatment of diseases associated with expression of acyl CoA cholesterol acyltransferase-2 are provided.
    Type: Application
    Filed: December 19, 2007
    Publication date: July 31, 2008
    Applicant: Isis Pharmaceuticals, Inc.
    Inventors: Rosanne M. Crooke, Kristina Lemonidis Tarbet, Mark J. Graham
  • Antisense modulation of acyl CoA cholesterol acyltransferase-2 expression
    Patent number: 7335764
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of acyl CoA cholesterol acyltransferase-2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding acyl CoA cholesterol acyltransferase-2. Methods of using these compounds for modulation of acyl CoA cholesterol acyltransferase-2 expression and for treatment of diseases associated with expression of acyl CoA cholesterol acyltransferase-2 are provided.
    Type: Grant
    Filed: February 20, 2007
    Date of Patent: February 26, 2008
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Rosanne M. Crooke, Kristina Lemonidis Tarbet, Mark J. Graham
  • Antisense modulation of acyl CoA cholesterol acyltransferase-2 expression
    Patent number: 7202357
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of acyl CoA cholesterol acyltransferase-2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding acyl CoA cholesterol acyltransferase-2. Methods of using these compounds for modulation of acyl CoA cholesterol acyltransferase-2 expression and for treatment of diseases associated with expression of acyl CoA cholesterol acyltransferase-2 are provided.
    Type: Grant
    Filed: July 15, 2002
    Date of Patent: April 10, 2007
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Rosanne M. Crooke, Mark J. Graham, Kristina Lemonidis Tarbet
  • Antisense modulation of acyl coa cholesterol acyltransferase-2 expression
    Publication number: 20040266705
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of acyl CoA cholesterol acyltransferase-2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding acyl CoA cholesterol acyltransferase-2. Methods of using these compounds for modulation of acyl CoA cholesterol acyltransferase-2 expression and for treatment of diseases associated with expression of acyl CoA cholesterol acyltransferase-2 are provided.
    Type: Application
    Filed: August 13, 2004
    Publication date: December 30, 2004
    Inventors: Rosanne M Crooke, Mark J Graham, Kristina Lemonidis Tarbet
  • Antisense modulation of apolipoprotein B expression
    Publication number: 20040214325
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of apolipoprotein B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding apolipoprotein B. Methods of using these compounds for modulation of apolipoprotein B expression and for treatment of diseases associated with expression of apolipoprotein B are provided.
    Type: Application
    Filed: November 13, 2003
    Publication date: October 28, 2004
    Inventors: Rosanne Crooke, Mark Graham, Kristina Lemonidis-Tarbet, Kenneth Dobie