Patents by Inventor Kristina M. Allen

Kristina M. Allen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Reagents and method for modulating Dkk-mediated interactions
    Patent number: 7700101
    Abstract: The present invention provides reagents, compounds, compositions, and methods relating to novel interactions of the extracellular domain of LRP5, HBM (a variant of LRP5), and/or LRP6 with Dkk, including Dkk-1. The various nucleic acids, polypeptides, antibodies, assay methods, diagnostic methods, and methods of treatment of the present invention are related to and impact on Dkk, LRP5, LRP6, HBM, and Wnt signaling. Dkk, LRP5, LRP6, HBM, and Wnt are implicated in bone and lipid cellular signaling. Thus, the present invention provides reagents and methods for modulating lipid levels and/or bone mass and is useful in the treatment and diagnosis of abnormal lipid levels and bone mass disorders, such as osteoporosis.
    Type: Grant
    Filed: January 22, 2007
    Date of Patent: April 20, 2010
    Assignees: Wyeth, Oscient Pharmaceuticals Corporation
    Inventors: Kristina M. Allen, Anthony Anisowicz, Veronique Damagnez, John A. Robinson, Paul J. Yaworsky, Bheem M. Bhat
  • Reagents and methods for modulating dkk-mediated interactions
    Publication number: 20040038860
    Abstract: The present invention provides reagents, compounds, compositions, and methods relating to novel interactions of the extracellular domain of LRP5, HBM (a variant of LRP5), and/or LRP6 with Dkk, including Dkk-1. The various nucleic acids, polypeptides, antibodies, assay methods, diagnostic methods, and methods of treatment of the present invention are related to and impact on Dkk, LRP5, LRP6, HBM, and Wnt signaling. Dkk, LRP5, LRP6, HBM, and Wnt are implicated in bone and lipid cellular signaling. Thus, the present invention provides reagents and methods for modulating lipid levels and/or bone mass and is useful in the treatment and diagnosis of abnormal lipid levels and bone mass disorders, such as osteoporosis.
    Type: Application
    Filed: August 2, 2002
    Publication date: February 26, 2004
    Inventors: Kristina M. Allen, Anthony Anisowicz, Veronique Damagnez