Patents by Inventor Kristine K. Kikly

Kristine K. Kikly has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sialoadhesin factor-2 antibodies
    Patent number: 8207305
    Abstract: Monoclonal antibodies have been generated that bind to human sialoadhesion factor-2. These antibodies are useful as diagnostic and therapeutic reagents.
    Type: Grant
    Filed: May 29, 2009
    Date of Patent: June 26, 2012
    Assignee: The John Hopkins University
    Inventors: Julie A. Abrahamson, Connie L. Erickson-Miller, Kristine K. Kikly, Bruce Bochner, Robert Schleimer, T. Esra Nutku
  • METHODS OF USE OF SIALOADHESIN FACTOR-2 ANTIBODIES
    Publication number: 20110217319
    Abstract: Monoclonal antibodies have been generated that bind to human sialoadhesion factor-2.
    Type: Application
    Filed: January 14, 2011
    Publication date: September 8, 2011
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Julie A. Abrahamson, Connie L. Erickson-Miller, Kristine K. Kikly, Bruce Bochner, Robert Schleimer, T. Esra Nutku
  • Methods of use of sialoadhesin factor-2 antibodies
    Patent number: 7871612
    Abstract: Monoclonal antibodies have been generated that bind to human sialoadhesion factor-2. These antibodies are useful as diagnostic and therapeutic reagents.
    Type: Grant
    Filed: October 12, 2006
    Date of Patent: January 18, 2011
    Assignee: The Johns Hopkins University
    Inventors: Julie A. Abrahamson, Connie L Erickson-Miller, Kristine K. Kikly, Bruce Bochner, Robert Schleimer, T. Esra Nutku
  • SIALOADHESIN FACTOR-2 ANTIBODIES
    Publication number: 20100056760
    Abstract: Monoclonal antibodies have been generated that bind to human sialoadhesion factor-2. These antibodies are useful as diagnostic and therapeutic reagents.
    Type: Application
    Filed: May 29, 2009
    Publication date: March 4, 2010
    Applicant: SmithKline Beecham Corporation
    Inventors: Julie A. ABRAHAMSON, Connie L. Erickson-Miller, Kristine K. Kikly, Bruce Bochner, Robert Schleimer, T. Esra Nutku
  • Sialoadhesin factor-2 antibodies
    Patent number: 7557191
    Abstract: Monoclonal antibodies have been generated that bind to human sialoadhesion factor-2. These antibodies are useful as diagnostic and therapeutic reagents.
    Type: Grant
    Filed: October 12, 2006
    Date of Patent: July 7, 2009
    Assignee: SmithKline Beecham Corporation
    Inventors: Julie A. Abrahamson, Connie L Erickson-Miller, Kristine K. Kikly, Bruce Bochner, Robert Schleimer
  • Sialoadhesin factor-2 antibodies
    Publication number: 20080213212
    Abstract: Monoclonal antibodies have been generated that bind to human sialoadhesion factor-2.
    Type: Application
    Filed: October 12, 2006
    Publication date: September 4, 2008
    Inventors: Julie A. Abrahamson, Connie L. Erickson-Miller, Kristine K. Kikly, Bruce Bochner, Robert Schleimer, T. Esra Nutku
  • Antagonistic Anti-hTNFSF13b Human Antibodies
    Publication number: 20080175841
    Abstract: Human monoclonal antibodies that specifically bind to TNFSF13b polypeptides are disclosed. These antibodies have high affinity for hTNFSF13b (e.g., KD=10?8 M or less), a slow off rate for TNFSF13b dissociation (e.g., Koff=10?3 sec?1 or less) and neutralize TNFSF13b activity in vitro and in vivo. The antibodies of the invention are useful in one embodiment for inhibiting TNFSF13b activity in a human subject suffering from a disorder in which hTNFSF13b activity is detrimental. Nucleic acids encoding the antibodies of the present invention, as well as, vectors and host cells for expressing them are also encompassed by the invention.
    Type: Application
    Filed: December 7, 2007
    Publication date: July 24, 2008
    Inventors: Valentina Pavlovna Gelfanova, John Edward Hale, Kristine K. Kikly, Radharishnan Rathnachalam, Derrick Ryan Witcher
  • Sialoadhesin family member-2 (SAF-2)
    Patent number: 7214772
    Abstract: SAF-2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing SAF-2 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: July 8, 2004
    Date of Patent: May 8, 2007
    Assignees: SmithKline Beecham Corporation, Johns Hopkins University
    Inventors: Kristine K Kikly, Connie Lyn Erickson-Miller, Bruce Bochner, Robert Schleimer
  • Interleukin-1? converting enzyme like apoptotic protease-6
    Patent number: 7115260
    Abstract: Human ICE LAP-6 polypeptides and DNA (RNA) encoding such ICE LAP-6 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such ICE LAP-6 for the treatment of a susceptibility to viral infection, tumorogenesis and to diseases and defects in the control embryogenesis and tissue homeostasis, and the nucleic acid sequences described above may be employed in an assay for ascertaining such susceptibility.
    Type: Grant
    Filed: October 12, 2004
    Date of Patent: October 3, 2006
    Assignees: Human Genome Sciences, Inc., SmithKline Beecham Corporation, The Regents of the University of Michigan
    Inventors: Vishva M. Dixit, Wei-Wu He, Kristine K. Kikly, Steven M. Ruben
  • Interleukin-1? converting enzyme like apoptotic protease-6
    Patent number: 6890721
    Abstract: Human ICE LAP-6 polypeptides and DNA (RNA) encoding such ICE LAP-6 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilize such ICE LAP-6 for the treatment of a susceptibility to viral infection, tumorogenesis and to diseases and defects in the control embryogenesis and tissue homeostasis, and the nucleic acid sequences described above may be employed in an assay for ascertaining such susceptibility.
    Type: Grant
    Filed: September 24, 2001
    Date of Patent: May 10, 2005
    Assignees: Human Genome Sciences, Inc., SmithKline Beecham Corporation, The Regents of the University of Michigan
    Inventors: Vishva M. Dixit, Wei-Wu He, Kristine K. Kikly, Steven M. Ruben
  • Sialoadhesin family member-2 (SAF-2)
    Publication number: 20040241805
    Abstract: SAF-2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing SAF-2 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Application
    Filed: July 8, 2004
    Publication date: December 2, 2004
    Applicant: SmithKline Beecham & Johns Hopkins University
    Inventors: Kristine K. Kikly, Connie Lyn Erickson-Miller, Bruce Bochner, Robert Schleimer
  • Sialoadhesin family member-2 (SAF-2)
    Publication number: 20040023278
    Abstract: SAF-2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing SAF-2 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Application
    Filed: May 22, 2003
    Publication date: February 5, 2004
    Applicant: SmithKline Beecham and Johns Hopkins University
    Inventors: Kristine K. Kikly, Connie Lyn Erickson-Miller, Bruce Bochner, Robert Schleimer
  • Sialoadhesin factor-2 antibodies
    Publication number: 20030092091
    Abstract: Monoclonal antibodies have been generated that bind to human sialoadhesion factor-2.
    Type: Application
    Filed: August 29, 2002
    Publication date: May 15, 2003
    Inventors: Julie A. Abrahamson, Connie L. Erickson-Miller, Kristine K. Kikly, Bruce Bochner, Robert Schleimer, T. Esra Nutku
  • Interleukin-1 beta converting enzyme like apoptotic protease-6
    Patent number: 6294169
    Abstract: Human ICE LAP-6 polypeptides and DNA (RNA) encoding such ICE LAP-6 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such ICE LAP-6 for the treatment of a susceptibility to viral infection, tumorogenesis and to diseases and defects in the control embryogenesis and tissue homeostasis, and the nucleic acid sequences described above may be employed in an assay for ascertaining such susceptibility.
    Type: Grant
    Filed: April 27, 1999
    Date of Patent: September 25, 2001
    Assignees: Human Genome Sciences, Inc., SmithKline Beecham Corporation, University of Michigan
    Inventors: Vishva M. Dixit, Wei-Wu He, Kristine K. Kikly, Steven M. Ruben
  • Interleukin-1 .beta. converting enzyme like apoptotic protease-6
    Patent number: 6010878
    Abstract: Human ICE LAP-6 polypeptides and DNA (RNA) encoding such ICE LAP-6 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such ICE LAP-6 for the treatment of a susceptibility to viral infection, tumorogenesis and to diseases and defects in the control embryogenesis and tissue homeostasis, and the nucleic acid sequences described above may be employed in an assay for ascertaining such susceptibility.
    Type: Grant
    Filed: May 8, 1997
    Date of Patent: January 4, 2000
    Assignee: Smithkline Beecham Corporation
    Inventors: Vishva M. Dixit, Wei-Wu He, Kristine K. Kikly, Steven M. Ruben
  • Interleukin-1 beta converting enzyme like apoptotic protease-7
    Patent number: 6008042
    Abstract: Human ICE LAP-7 polypeptides and DNA (RNA) encoding such ICE LAP-7 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such ICE LAP-7 for the treatment of a susceptibility to viral infection, tumorogenesis and to diseases and defects in the control embryogenesis and tissue homeostasis, and the nucleic acid sequences described above may be employed in an assay for ascertaining such susceptibility.
    Type: Grant
    Filed: May 7, 1997
    Date of Patent: December 28, 1999
    Assignees: Smithkline Beecham Corporation, The Regents of the University of Michigan, Human Genome Sciences, Inc.
    Inventors: Vishva M. Dixit, Kristine K. Kikly, Steven M. Ruben, Jian Ni, Craig A. Rosen