Patents by Inventor Kristine M. Muller

Kristine M. Muller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Quinolone based compounds exhibiting, prolyl hydroxylase inhibitory activity, and compositions, and uses thereof
    Patent number: 8017626
    Abstract: This invention relates to new quinolone based compounds that exhibit prolyl hydroxylase inhibitory activity. This invention also relates to methods of increasing HIF levels or activity in a subject or treating a condition associated with HIF levels or activity in a subject by administering to the subject at least one quinolone based compound. This invention further involves assays for the detection of a hydroxyproline residue in a HIF molecule.
    Type: Grant
    Filed: February 10, 2010
    Date of Patent: September 13, 2011
    Assignee: Amgen Inc.
    Inventors: Jennifer R. Allen, Kaustav Biswas, Roland Burli, Jennifer Dao, Michael J. Frohn, Jennifer E. Golden, Randall W. Hungate, Robert Kurzeja, Stephanie J. Mercede, Kristine M. Muller, Susana C. Neira, Tanya A. N. Peterkin, Christopher M. Tegley, Violeta Yu
  • Quinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, and compositions, and uses thereof
    Patent number: 8012968
    Abstract: This invention relates to new quinolone based compounds that exhibit prolyl hydroxylase inhibitory activity. This invention also relates to methods of increasing HIF levels or activity in a subject or treating a condition associated with HIF levels or activity in a subject by administering to the subject at least one quinolone based compound. This invention further involves assays for the detection of a hydroxyproline residue in a HIF molecule.
    Type: Grant
    Filed: February 10, 2010
    Date of Patent: September 6, 2011
    Assignee: Amgen Inc.
    Inventors: Jennifer R. Allen, Kaustav Biswas, Roland Burli, Jennifer Dao, Michael J. Frohn, Jennifer E. Golden, Randall W. Hungate, Robert Kurzeja, Stephanie J. Mercede, Kristine M. Muller, Susana C. Neira, Tanya A. N. Peterkin, Christopher M. Tegley, Violeta Yu
  • QUINOLONE BASED COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF
    Publication number: 20100240610
    Abstract: This invention relates to new quinolone based compounds that exhibit prolyl hydroxylase inhibitory activity. This invention also relates to methods of increasing HIF levels or activity in a subject or treating a condition associated with HIF levels or activity in a subject by administering to the subject at least one quinolone based compound. This invention further involves assays for the detection of a hydroxyproline residue in a HIF molecule.
    Type: Application
    Filed: February 10, 2010
    Publication date: September 23, 2010
    Inventors: JENNIFER R. ALLEN, KAUSTAV BISWAS, ROLAND BURLI, JENNIFER DAO, MICHAEL J. FROHN, JENNIFER E. GOLDEN, RANDALL W. HUNGATE, ROBERT KURZEJA, STEPHANIE J. MERCEDE, KRISTINE M. MULLER, SUSANA C. NEIRA, TANYA A. N. PETERKIN, CHRISTOPHER M. TEGLEY, VIOLETA YU
  • QUINOLONE BASED COMPOUNDS EXHIBITING, PROLYL HYDROXYLASE INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF
    Publication number: 20100184763
    Abstract: This invention relates to new quinolone based compounds that exhibit prolyl hydroxylase inhibitory activity. This invention also relates to methods of increasing HIF levels or activity in a subject or treating a condition associated with HIF levels or activity in a subject by administering to the subject at least one quinolone based compound. This invention further involves assays for the detection of a hydroxyproline residue in a HW molecule.
    Type: Application
    Filed: February 10, 2010
    Publication date: July 22, 2010
    Inventors: Jennifer R. Allen, Kaustav Biswas, Roland Burli, Jennifer Dao, Michael J. Frohn, Jennifer E. Golden, Randall W. Hungate, Robert Kurzeja, Stephanie J. Mercede, Kristine M. Muller, Susana C. Neira, Tanya A. N. Peterkin, Christopher M. Tegley, Violeta Yu
  • Quinolone based compounds exhibiting prolyl hydroxylase inhibitory activity
    Patent number: 7728130
    Abstract: This invention relates to new quinolone based compounds that exhibit prolyl hydroxylase inhibitory activity. This invention also relates to methods of increasing HIF levels or activity in a subject or treating a condition associated with HIF levels or activity in a subject by administering to the subject at least one quinolone based compound. This invention further involves assays for the detection of a hydroxyproline residue in a HIF molecule.
    Type: Grant
    Filed: December 8, 2006
    Date of Patent: June 1, 2010
    Assignee: Amgen Inc.
    Inventors: Jennifer R. Allen, Kaustav Biswas, Roland Burli, Jennifer Dao, Michael J. Frohn, Jennifer E. Golden, Randall W. Hungate, Robert Kurzeja, Stephanie J. Mercede, Kristine M. Muller, Susana C. Neira, Tanya A. N. Peterkin, Christopher M. Tegley, Violeta Yu
  • Indanone derivatives that inhibit prolyl hydroxylase
    Patent number: 7569726
    Abstract: Compounds of Formula I are useful inhibitors of HIF prolyl hydroxylases. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.
    Type: Grant
    Filed: April 9, 2008
    Date of Patent: August 4, 2009
    Assignee: Amgen Inc.
    Inventors: Jennifer R. Allen, Roland Burli, Jennifer E. Golden, Kristine M. Muller, Anthony B. Reed
  • Indanone derivatives that inhibit prolyl hydroxylase
    Publication number: 20090088475
    Abstract: Compounds of Formula I are useful inhibitors of HIF prolyl hydroxylases. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.
    Type: Application
    Filed: April 9, 2008
    Publication date: April 2, 2009
    Applicant: Amgen Inc.
    Inventors: Jennifer R. Allen, Roland Burli, Jennifer E. Golden, Kristine M. Muller, Anthony B. Reed