Patents by Inventor Kristine MCKINNEY

Kristine MCKINNEY has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MESSENGER RIBONUCLEIC ACIDS FOR THE PRODUCTION OF INTRACELLULAR BINDING POLYPEPTIDES AND METHODS OF USE THEREOF
    Publication number: 20210206818
    Abstract: The invention features isolated mRNAs encoding at least one intracellular binding domain, including mRNAs comprising one or more modified nucleobase and preferably lacking an encoded scaffold polypeptide, and methods of using the same, for example, for inducing apoptosis and/or treating cancer (e.g., liver cancer or colorectal cancer).
    Type: Application
    Filed: January 20, 2017
    Publication date: July 8, 2021
    Inventors: Eric Yi-Chun HUANG, Joshua P. FREDERICK, Kristine MCKINNEY, Christina HENDERSON, Kahlin CHEUNG-ONG, Joseph BOLEN, Stephen Michael KELSEY, Michael MORIN, Sushma GURUMURTHY, Kerry BENENATO, Stephen HOGE, Iain MCFADYEN, Vladimir PRESNYAK
  • IMMUNOMODULATORY THERAPEUTIC MRNA COMPOSITIONS ENCODING ACTIVATING ONCOGENE MUTATION PEPTIDES
    Publication number: 20210128721
    Abstract: The disclosure features immunomodulatory therapeutic compositions of an mRNA encoding an activating oncogene mutation peptide and an mRNA encoding a polypeptide that enhances immune responses to the activating oncogene mutation peptide, for example an mRNA encoding an immune potentiator. The disclosure also features methods of using the same, for example, to stimulate anti-cancer immune responses.
    Type: Application
    Filed: November 18, 2020
    Publication date: May 6, 2021
    Inventors: Eric Yi-Chun HUANG, Sze-Wah TSE, Jared IACOVELLI, Kristine MCKINNEY, Nicholas VALIANTE
  • Immunomodulatory therapeutic MRNA compositions encoding activating oncogene mutation peptides
    Patent number: 10881730
    Abstract: The disclosure features immunomodulatory therapeutic compositions of an mRNA encoding an activating oncogene mutation peptide and an mRNA encoding a polypeptide that enhances immune responses to the activating oncogene mutation peptide, for example an mRNA encoding an immune potentiator. The disclosure also features methods of using the same, for example, to stimulate anti-cancer immune responses.
    Type: Grant
    Filed: February 19, 2019
    Date of Patent: January 5, 2021
    Assignee: ModernaTX, Inc.
    Inventors: Eric Yi-Chun Huang, Sze-Wah Tse, Jared Iacovelli, Kristine McKinney, Nicholas Valiante
  • MESSENGER RIBONUCLEIC ACIDS FOR ENHANCING IMMUNE RESPONSES AND METHODS OF USE THEREOF
    Publication number: 20200261572
    Abstract: The disclosure features isolated mRNAs encoding a polypeptide that enhances immune responses to an antigen(s) of interest, such as polypeptides that activate Type I interferon pathway signaling or NFkB signaling, including mRNAs comprising one or more modified nucleobase. The disclosure also features methods of using the same, for example, for enhancing immune responses when administered with an antigen(s) of interest, such as to stimulate anti-cancer immune responses or anti-pathogen immune responses.
    Type: Application
    Filed: November 1, 2019
    Publication date: August 20, 2020
    Inventors: Eric Yi-Chun HUANG, Sze-Wah TSE, Jared IACOVELLI, Kristine MCKINNEY, Kristen HOPSON
  • IMMUNOMODULATORY THERAPEUTIC MRNA COMPOSITIONS ENCODING ACTIVATING ONCOGENE MUTATION PEPTIDES
    Publication number: 20190351039
    Abstract: The disclosure features immunomodulatory therapeutic compositions of an mRNA encoding an activating oncogene mutation peptide and an mRNA encoding a polypeptide that enhances immune responses to the activating oncogene mutation peptide, for example an mRNA encoding an immune potentiator. The disclosure also features methods of using the same, for example, to stimulate anti-cancer immune responses.
    Type: Application
    Filed: February 1, 2018
    Publication date: November 21, 2019
    Inventors: Eric Yi-Chun HUANG, Sze-Wah TSE, Jared IACOVELLI, Kristine MCKINNEY, Nicholas VALIANTE
  • IMMUNOMODULATORY THERAPEUTIC MRNA COMPOSITIONS ENCODING ACTIVATING ONCOGENE MUTATION PEPTIDES
    Publication number: 20190175727
    Abstract: The disclosure features immunomodulatory therapeutic compositions of an mRNA encoding an activating oncogene mutation peptide and an mRNA encoding a polypeptide that enhances immune responses to the activating oncogene mutation peptide, for example an mRNA encoding an immune potentiator. The disclosure also features methods of using the same, for example, to stimulate anti-cancer immune responses.
    Type: Application
    Filed: February 19, 2019
    Publication date: June 13, 2019
    Inventors: Eric Yi-Chun HUANG, Sze-Wah TSE, Jared IACOVELLI, Kristine MCKINNEY, Nicholas VALIANTE
  • MESSENGER RIBONUCLEIC ACIDS FOR THE PRODUCTION OF INTRACELLULAR BINDING POLYPEPTIDES AND METHODS OF USE THEREOF
    Publication number: 20190119357
    Abstract: The invention features isolated mRNAs encoding fusion polypeptides comprising a Stefm A (SteA) scaffold polypeptide and one or more binding polypeptides, such as one or more Bc1-2 homology 3 (BH3) domains, including mRNAs comprising one or more modified nucleobase, and methods of using the same, for example, for inducing apoptosis and/or treating cancer (e.g., liver cancer or colorectal cancer).
    Type: Application
    Filed: July 22, 2016
    Publication date: April 25, 2019
    Inventors: Eric Yi-chun HUANG, Josh FREDERICK, Kristine MCKINNEY, Christina HENDERSON, Kahlin CHEUNG-ONG, Joseph BOLEN, Stephen Michael KELSEY, Michael MORIN, Sushma GURUMURTHY
  • MESSENGER RIBONUCLEIC ACIDS FOR ENHANCING IMMUNE RESPONSES AND METHODS OF USE THEREOF
    Publication number: 20180311343
    Abstract: The disclosure features isolated mRNAs encoding a polypeptide that enhances immune responses to an antigen(s) of interest, such as polypeptides that activate Type I interferon pathway signaling or NFkB signaling, including mRNAs comprising one or more modified nucleobase. The disclosure also features methods of using the same, for example, for enhancing immune responses when administered with an antigen(s) of interest, such as to stimulate anti-cancer immune responses or anti-pathogen immune responses.
    Type: Application
    Filed: June 1, 2018
    Publication date: November 1, 2018
    Inventors: Eric Yi-Chun HUANG, Sze-Wah TSE, Jared IACOVELLI, Kristine MCKINNEY, Kristen HOPSON
  • MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF INTRABODIES
    Publication number: 20170210788
    Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of modified polynucleotides comprising at least one intrabody construct.
    Type: Application
    Filed: July 23, 2015
    Publication date: July 27, 2017
    Inventors: Eric Yi-Chun HUANG, Josh FREDERICK, Kristine MCKINNEY, Christina HENDERSON