Abstract: Provided are computer-implemented methods for producing an index. The methods include conditioning electroencephalographic (EEG) signals present in an EEG recording previously obtained from an individual, e.g., an individual having dementia. In certain embodiments, the methods further include determining frequency domain features from the conditioned EEG signals, and determining connectivity features from the frequency domain features, where the connectivity features include connectivity features determined from a frequency range of from 35 Hz to 45 Hz divided into two or more sub-bands. The methods further include producing an index calculated at least in part as a function of one or more of the connectivity features determined from a frequency range of from 35 Hz to 45 Hz divided into sub-bands with varying contribution to the calculation of the index. Also provided are computer readable media and computer devices that find use, e.g., in practicing the methods of the present disclosure.

Abstract: This invention relates to a method and a system for generating a quantitative measure reflecting the severity of a medical condition. A receiver unit receives biosignal data collected from a population of patients having varying degrees of the medical condition. A processor uses the biosignal data for determining reference feature values for each respective patient within the population, where the determining being made in accordance to a pre-defined set of reference features. The processor then assigns each respective patient within the population of patients with a reference feature vector having as vector elements the reference feature values associated with the patient. The processor also uses the reference feature vectors of the patients as input in determining combinations of features describing the variance in the data, where the size of the combinations is an indicator for the severity of the medical condition.

Abstract: This invention relates to a method and a system for generating a discriminatory signal for a neurological condition, where at least one probe compound that has a neurophysiologic effect is provided. Biosignal data are obtained from a subject based on biosignal measurements obtained from biosignal measuring device adapted for placement on a subject, wherein said biosignal data are obtained posterior to the administering of said probe compound to the subject.

Abstract: This invention relates to constructing a reference tool and using the reference tool for distinguishing between a medical condition of a subject and a reference subject. This tool may be considered as a reference “map” consisting of one or several numbers of reference groups, where the subjects within the same groups share one or more common characteristics, e.g. age, sex, medical condition, etc. The present invention therefore relates to seeing whether a subject to be diagnosed falls within one or more of said groups simply by comparing processed biological data collected from the subject with the reference “map”.

Abstract: A device is provided with tunable affinity for molecules such as in particular macromlecues including proteins and peptides. The device comprises a substrate with a surface; a plurality of locally substantially parallel electrodes along said surface, wherein adjacent electrodes are separated by a distance in the range of about 0.1 nm to about 1 ?m, such as about 0.3 nm to about 10 nm, where each of said electrodes is connected to a tunable EMF source, such that a specific electrostatic environment perpendicular to said electrodes is created, extending along the electrodes, and providing a continuous binding area for molecules in contact with the binding area. By tuning the independently tunable EMF sources a specific affinity or repulsion is obtainable for molecules with specific electrostatic properties. Also provided are methods for separating and isolating molecules with a device such as is disclosed herein.