Abstract: The present invention relates to compounds that are useful as radioimaging agents and radiopharmaceuticals. The compounds may be coordinated with a radionuclide and may be useful in diagnostic imaging and radiotherapy. The invention also relates to methods of prognosis and therapy utilising the non-coordinated and radiolabelled compounds of the invention.

Abstract: Provided herein is a dendrimer comprising: i) a core unit (C); and ii) building units (BU), wherein the core unit is covalently attached to at least two building units; the dendrimer having from two to six generations of building units; wherein building units of different generations are covalently attached to one another; and the dendrimer further comprising: iii) one or more first terminal groups attached to an outermost building unit, wherein each first terminal group comprises a radionuclide-containing moiety; and iv) one or more second terminal groups attached to an outermost building unit, wherein each second terminal group comprises a pharmacokinetic-modifying moiety; or a salt thereof. Also provided are compositions comprising the dendrimers, and methods of using the dendrimers and compositions in diagnostic and therapeutic applications.

Abstract: An injectable detecting device is provided for use in physiological monitoring. The device includes a plurality of sensors axially spaced along a body that provide an indication of at least one physiological event of a patient, a monitoring unit within the body coupled to the plurality of sensors configured to receive data from the plurality of sensors and create processed patient data, a power source within the body coupled to the monitoring unit, and a communication antenna external to the body coupled to the monitoring unit configured to transfer data to/from other devices.

Abstract: An injectable detecting device is provided for use in physiological monitoring. The device includes a plurality of sensors axially spaced along a body that provide an indication of at least one physiological event of a patient, a monitoring unit within the body coupled to the plurality of sensors configured to receive data from the plurality of sensors and create processed patient data, a power source within the body coupled to the monitoring unit, and a communication antenna external to the body coupled to the monitoring unit configured to transfer data to/from other devices.

Abstract: An injectable detecting device is provided for use in physiological monitoring. The device includes a plurality of sensors axially spaced along a body that provide an indication of at least one physiological event of a patient, a monitoring unit within the body coupled to the plurality of sensors configured to receive data from the plurality of sensors and create processed patient data, a power source within the body coupled to the monitoring unit, and a communication antenna external to the body coupled to the monitoring unit configured to transfer data to/from other devices.

Abstract: An injectable detecting device is provided for use in physiological monitoring. The device includes a plurality of sensors axially spaced along a body that provide an indication of at least one physiological event of a patient, a monitoring unit within the body coupled to the plurality of sensors configured to receive data from the plurality of sensors and create processed patient data, a power source within the body coupled to the monitoring unit, and a communication antenna external to the body coupled to the monitoring unit configured to transfer data to/from other devices.

Abstract: A system for tracking a patient's physiological status and detecting and predicting negative physiological events, with a detecting system and a remote monitoring system. The detecting system includes a plurality of sensors that provide an indication of at least one physiological event of a patient, and a wireless communication device coupled to the plurality of sensors, and configured to transfer patient data from the plurality of sensors to a remote monitoring system. The a remote monitoring system coupled to the wireless communication device, wherein during a registration period, the detecting system being activated for a first time and communicating with the remote monitoring system to register the detecting system and activate data logging.

Abstract: A method for determining a recovery voltage in a battery includes detecting a transient increased current draw event drawing current from the battery, the transient increased current draw event starting at a start time and ending at an end time; and in response to detecting the transient increased current draw event, waiting until time and/or voltage criteria are met to determine recovered battery voltage. An implantable pulse generator (PG) device for stimulating a human organ includes a battery, a power sink drawing current from the battery, wherein drawing increased current from the battery for transient periods causes battery voltage to decrease; and a status indicator detecting a transient increased current draw event and waiting a minimum time duration after the transient increased current draw event to measure battery voltage in order to determine a recovery voltage.

Abstract: Various aspects provide an implantable device. In various embodiments, the device comprises at least one port, where each port is adapted to connect a lead with an electrode to the device. The device further includes a stimulation platform, including a sensing circuit connected to the at least one port to sense an intrinsic cardiac signal and a stimulation circuit connected to the at least one port via a stimulation channel to deliver a stimulation signal through the stimulation channel to the electrode. The stimulation circuit is adapted to deliver stimulation signals through the stimulation channel for both neural stimulation therapy and CRM therapy. The sensing and stimulation circuits are adapted to perform CRM functions. The device further includes a controller connected to the sensing circuit and the stimulation circuit to control the neural stimulation therapy and the CRM therapy. Other aspects and embodiments are provided herein.

Abstract: A method for determining a recovery voltage in a battery includes detecting a transient increased current draw event drawing current from the battery, the transient increased current draw event starting at a start time and ending at an end time; and in response to detecting the transient increased current draw event, waiting until time and/or voltage criteria are met to determine recovered battery voltage. An implantable pulse generator (PG) device for stimulating a human organ includes a battery, a power sink drawing current from the battery, wherein drawing increased current from the battery for transient periods causes battery voltage to decrease; and a status indicator detecting a transient increased current draw event and waiting a minimum time duration after the transient increased current draw event to measure battery voltage in order to determine a recovery voltage.

Abstract: An apparatus and method for determining the condition of a battery in an implantable cardiac rhythm management device is described. A battery's status is determined from a record of the device's operational history. The operational history may include the total number of events or event durations recorded during a specified time period. The battery charge consumption is then estimated by means of charge coefficients associated with each type of event.

Abstract: This document discusses, among other things, a system and method of monitoring or reporting battery status of an implantable medical device. The battery terminal voltage and charge delivered are measured. Before the battery terminal voltage falls below an Elective Replacement Indicator (ERI) threshold voltage, a charge-delivered indication of battery status is provided. Thereafter, a battery terminal voltage indication of battery status is provided. The Elective Replacement Indicator (ERI) and End of Life (EOL) threshold voltages are each functions of delivered battery current. A fault current detection is also provided. A device temperature sensor discounts the battery voltage reading when the device is too cold.

Abstract: A manganese dioxide (MnO2) or silver vanadium oxide (SVO) or other battery of an implantable medical device having a relatively flat quiescent battery voltage during a beginning portion of the battery's useful life, makes it difficult to use quiescent battery voltage as an indicator of remaining battery energy during this portion of the battery life. A substantially constant load current pulse is drawn from the battery and a pair of loaded battery terminal voltage measurements is taken during this pulse. A difference between the voltage measurements is computed. This difference can be expressed as a rate of change, a slope, or a polarization angle, and can be used with stored data from similar batteries to determine remaining energy of the battery. A quiescent battery voltage can also be used in combination with this technique, and/or for distinguishing between different remaining energies corresponding to the same difference, slope, or polarization angle.