Patents by Inventor Kristoffer Tobias, Gustav RIGBOLT

Kristoffer Tobias, Gustav RIGBOLT has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • hAM15-52 ANALOGUES WITH IMPROVED AMYLIN RECEPTOR (hAMY3R) POTENCY
    Publication number: 20240101634
    Abstract: The present invention relates to hAM15-52 analogues with improved amylin receptor (hAMY3R) potency (hAMY3R-EC50?250 pM) and which are largely based on the sequence of the human adrenomedullin fragment hAM15-52. The invention further relates to hAM15-52 analogues that are selective amylin receptor (hAMY3R) agonists (hAMY3R-EC50?250 pM and an hAM1R-EC50?25 nM) and which are largely based on the sequence of the human adrenomedullin fragment hAM15-52. The hAM15-52 analogues according to the invention maintain the good physical stability of hAM15-52. The invention further relates to pharmaceutical compositions comprising such polypeptides and their use in the treatment of a medical condition such as obesity, NASH and/or diabetes.
    Type: Application
    Filed: September 23, 2021
    Publication date: March 28, 2024
    Applicant: GUBRA A/S
    Inventors: Jens Christian Frøslev NIELSEN, Kristoffer Tobias, Gustav RIGBOLT, Esben Matzen BECH, Morten LUNDH, Paola MAGOTTI, Borja BALLARiN-GONZÁLEZ, Søren Ljungberg PEDERSEN, Nieis VRANG