Patents by Inventor Kristopher Barbee
Kristopher Barbee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11899029Abstract: The present teachings provide apparatuses and methods for automated handling of samples, e.g., biological or chemical samples. The apparatuses and the methods of the present teachings allow automated performance of various sample manipulation steps without manual intervention. In a preferred embodiment, the present teachings provide apparatuses and methods for automated enrichment of templated beads produced by PCR.Type: GrantFiled: November 17, 2022Date of Patent: February 13, 2024Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Kristopher Barbee, Maximilian Carpino, Ray Wheeling, Nicholas Peter Bajka
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Publication number: 20240027425Abstract: Provided are systems and methods for analyte detection and analysis. A system can comprise an open substrate configured to rotate. The open substrate can comprise an array of immobilized analytes. A solution comprising a plurality of probes may be directed, via centrifugal force, across the array during rotation of the substrate, to couple at least one of the plurality of probes with at least one of the analytes to form a bound probe. A detector can be configured to detect a signal from the bound probe via continuous rotational area scanning of the substrate.Type: ApplicationFiled: July 20, 2023Publication date: January 25, 2024Inventors: Kristopher BARBEE, Nathan BECKETT, Denis PRISTINSKI, Derek SCHULTE, Avishai BARTOV, Jamie SULLIVAN, Dumitru BRINZA, Abizar LAKDAWALLA, Steven MENCHEN, Gilad ALMOGY, Mark PRATT
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Patent number: 11747323Abstract: Provided are systems and methods for analyte detection and analysis. A system can comprise an open substrate configured to rotate. The open substrate can comprise an array of immobilized analytes. A solution comprising a plurality of probes may be directed, via centrifugal force, across the array during rotation of the substrate, to couple at least one of the plurality of probes with at least one of the analytes to form a bound probe. A detector can be configured to detect a signal from the bound probe via continuous rotational area scanning of the substrate.Type: GrantFiled: October 7, 2022Date of Patent: September 5, 2023Assignee: ULTIMA GENOMICS, INC.Inventors: Kristopher Barbee, Nathan Beckett, Denis Pristinski, Derek Schulte, Avishai Bartov, Jamie Sullivan, Dumitru Brinza, Abizar Lakdawalla, Steven Menchen, Gilad Almogy, Mark Pratt
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Patent number: 11732298Abstract: Provided are methods for biological sample processing and analysis. A method can comprise providing a substrate configured to rotate. The substrate can comprise an array having immobilized thereto a biological analyte. A solution comprising a plurality of probes may be directed, via centrifugal force, across the substrate during rotation of the substrate, to couple at least one of the plurality of probes with the biological analyte. A detector can be configured to detect a signal from the at least one probe coupled to the biological analyte, thereby analyzing the biological analyte.Type: GrantFiled: May 20, 2019Date of Patent: August 22, 2023Assignee: Ultima Genomics, Inc.Inventors: Gilad Almogy, Kristopher Barbee, Nathan Beckett
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Patent number: 11724265Abstract: A rotor assembly includes a rotor plate to rotate around a first axis; a bucket rotatably attached to the rotor plate and to rotate around a second axis; and a stop plate to rotate around the first axis relative to the rotor plate between an open position and a closed position, when in the closed position, the stop plate is to engage the bucket to fix an angular position of the bucket relative to a plane of rotation of the rotor assembly.Type: GrantFiled: February 5, 2021Date of Patent: August 15, 2023Inventors: Kristopher Barbee, Rui Zheng, Sean McCusker
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Publication number: 20230152300Abstract: Provided are systems and methods for analyte detection and analysis. A system can comprise an open substrate configured to rotate. The open substrate can comprise an array of immobilized analytes. A solution comprising a plurality of probes may be directed, via centrifugal force, across the array during rotation of the substrate, to couple at least one of the plurality of probes with at least one of the analytes to form a bound probe. A detector can be configured to detect a signal from the bound probe via continuous rotational area scanning of the substrate.Type: ApplicationFiled: October 7, 2022Publication date: May 18, 2023Inventors: Kristopher BARBEE, Nathan BECKETT, Denis PRISTINSKI, Derek SCHULTE, Avishai BARTOV, Jamie SULLIVAN, Dumitru BRINZA, Abizar LAKDAWALLA, Steven MENCHEN, Gilad ALMOGY, Mark PRATT
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Publication number: 20230069977Abstract: The present teachings provide apparatuses and methods for automated handling of samples, e.g., biological or chemical samples. The apparatuses and the methods of the present teachings allow automated performance of various sample manipulation steps without manual intervention. In a preferred embodiment, the present teachings provide apparatuses and methods for automated enrichment of templated beads produced by PCR.Type: ApplicationFiled: November 17, 2022Publication date: March 9, 2023Inventors: Kristopher Barbee, Maximilian Carpino, Ray Wheeling, Nicholas Peter Bajka
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Patent number: 11591651Abstract: Provided are methods for biological sample processing and analysis. A method can comprise providing a substrate configured to rotate. The substrate can comprise an array having immobilized thereto a biological analyte. A solution comprising a plurality of probes may be directed, via centrifugal force, across the substrate during rotation of the substrate, to couple at least one of the plurality of probes with the biological analyte. A detector can be configured to detect a signal from the at least one probe coupled to the biological analyte, thereby analyzing the biological analyte.Type: GrantFiled: November 5, 2020Date of Patent: February 28, 2023Assignee: Ultima Genomics, Inc.Inventors: Gilad Almogy, Kristopher Barbee, Nathan Beckett
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Patent number: 11513133Abstract: The present teachings provide apparatuses and methods for automated handling of samples, e.g., biological or chemical samples. The apparatuses and the methods of the present teachings allow automated performance of various sample manipulation steps without manual intervention. In a preferred embodiment, the present teachings provide apparatuses and methods for automated enrichment of templated beads produced by PCR.Type: GrantFiled: November 16, 2018Date of Patent: November 29, 2022Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Kristopher Barbee, Maximilian Carpino, Ray Wheeling, Nicholas Bajka
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Patent number: 11512350Abstract: Provided are methods for biological sample processing and analysis. A method can comprise providing a substrate configured to rotate. The substrate can comprise an array having immobilized thereto a biological analyte. A solution comprising a plurality of probes may be directed, via centrifugal force, across the substrate during rotation of the substrate, to couple at least one of the plurality of probes with the biological analyte. A detector can be configured to detect a signal from the at least one probe coupled to the biological analyte, thereby analyzing the biological analyte.Type: GrantFiled: November 5, 2020Date of Patent: November 29, 2022Assignee: Ultima Genomics, Inc.Inventors: Gilad Almogy, Kristopher Barbee, Nathan Beckett
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Patent number: 11499962Abstract: Provided are systems and methods for analyte detection and analysis. A system can comprise an open substrate configured to rotate. The open substrate can comprise an array of immobilized analytes. A solution comprising a plurality of probes may be directed, via centrifugal force, across the array during rotation of the substrate, to couple at least one of the plurality of probes with at least one of the analytes to form a bound probe. A detector can be configured to detect a signal from the bound probe via continuous rotational area scanning of the substrate.Type: GrantFiled: April 29, 2020Date of Patent: November 15, 2022Assignee: ULTIMA GENOMICS, INC.Inventors: Kristopher Barbee, Nathan Beckett, Denis Pristinski, Derek Schulte, Avishai Bartov, Jamie Sullivan, Dumitru Brinza, Abizar Lakdawalla, Steven Menchen, Gilad Almogy, Mark Pratt
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Publication number: 20220162696Abstract: Provided are systems and methods for analyte detection and analysis. A system can comprise an open substrate. The open substrate may be configured to rotate or otherwise move. The open substrate can comprise an array of individually addressable locations, with analytes immobilized thereto. The substrate may be spatially indexed to identify nucleic acid molecules from one or more sources, and/or sequences thereof, with the respective one or more sources. A solution comprising a plurality of probes may be directed across the array to couple at least one of the plurality of probes with at least one of the analytes to form a bound probe. A detector can be configured to detect a signal from the bound probe via scanning of the substrate while minimizing temperature fluctuations of the substrate or optical aberrations caused by bubbles.Type: ApplicationFiled: December 6, 2021Publication date: May 26, 2022Inventors: Nathan BECKETT, Gilad ALMOGY, Nathan CASWELL, Jacob A. WOLF, Kristopher BARBEE, Denis PRISTINSKI, Mark PRATT, Gene POLOVY, Osip SCHWARTZ, Stephanie KUBECKA, Steven MENCHEN, Joseph ANTHONY, Jose Martin SOSA, Phillip You Fai LEE
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Patent number: 11268143Abstract: Provided are systems and methods for analyte detection and analysis. A system can comprise an open substrate. The open substrate may be configured to rotate or otherwise move. The open substrate can comprise an array of individually addressable locations, with analytes immobilized thereto. The substrate may be spatially indexed to identify nucleic acid molecules from one or more sources, and/or sequences thereof, with the respective one or more sources. A solution comprising a plurality of probes may be directed across the array to couple at least one of the plurality of probes with at least one of the analytes to form a bound probe. A detector can be configured to detect a signal from the bound probe via scanning of the substrate while minimizing temperature fluctuations of the substrate or optical aberrations caused by bubbles.Type: GrantFiled: May 5, 2021Date of Patent: March 8, 2022Assignee: Ultima Genomics, Inc.Inventors: Nathan Beckett, Gilad Almogy, Nathan Caswell, Jacob A. Wolf, Kristopher Barbee, Denis Pristinski, Mark Pratt, Gene Polovy, Osip Schwartz, Stephanie Kubecka, Steven Menchen, Joseph Anthony, Jose Martin Sosa, Phillip You Fai Lee
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Publication number: 20210277464Abstract: Provided are systems and methods for analyte detection and analysis. A system can comprise an open substrate. The open substrate may be configured to rotate or otherwise move. The open substrate can comprise an array of individually addressable locations, with analytes immobilized thereto. The substrate may be spatially indexed to identify nucleic acid molecules from one or more sources, and/or sequences thereof, with the respective one or more sources. A solution comprising a plurality of probes may be directed across the array to couple at least one of the plurality of probes with at least one of the analytes to form a bound probe. A detector can be configured to detect a signal from the bound probe via scanning of the substrate while minimizing temperature fluctuations of the substrate or optical aberrations caused by bubbles.Type: ApplicationFiled: May 5, 2021Publication date: September 9, 2021Inventors: Nathan BECKETT, Gilad ALMOGY, Nathan CASWELL, Jacob A. WOLF, Kristopher BARBEE, Denis PRISTINSKI, Mark PRATT, Gene POLOVY, Osip SCHWARTZ, Stephanie KUBECKA, Steven MENCHEN, Joseph ANTHONY, Jose Martin SOSA, Phillip You Fai LEE
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Publication number: 20210199647Abstract: Provided are systems and methods for analyte detection and analysis. A system can comprise an open substrate. The open substrate may be configured to rotate or otherwise move. The open substrate can comprise an array of individually addressable locations, with analytes immobilized thereto. The substrate may be spatially indexed to identify nucleic acid molecules from one or more sources, and/or sequences thereof, with the respective one or more sources. A solution comprising a plurality of probes may be directed across the array to couple at least one of the plurality of probes with at least one of the analytes to form a bound probe. A detector can be configured to detect a signal from the bound probe via scanning of the substrate while minimizing temperature fluctuations of the substrate or optical aberrations caused by bubbles.Type: ApplicationFiled: February 22, 2021Publication date: July 1, 2021Inventors: Nathan BECKETT, Gilad ALMOGY, Nathan CASWELL, Jacob A. WOLF, Kristopher BARBEE, Denis PRISTINSKI, Mark PRATT, Gene POLOVY, Osip SCHWARTZ, Stephanie KUBECKA, Steven MENCHEN, Joseph ANTHONY, Jose Martin SOSA, Phillip You Fai LEE
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Publication number: 20210154683Abstract: A rotor assembly includes a rotor plate to rotate around a first axis; a bucket rotatably attached to the rotor plate and to rotate around a second axis; and a stop plate to rotate around the first axis relative to the rotor plate between an open position and a closed position, when in the closed position, the stop plate is to engage the bucket to fix an angular position of the bucket relative to a plane of rotation of the rotor assembly.Type: ApplicationFiled: February 5, 2021Publication date: May 27, 2021Inventors: Kristopher BARBEE, Rui ZHENG, Sean MCCUSKER
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Publication number: 20210139949Abstract: A sample preparation apparatus includes a robotic system providing movement in three orthogonal directions to an arm operable to receive a pipette tip and to facilitate movement of fluid into and out of the pipette tip. Optionally, the robot can include a gripper arm in addition to the pipette receiving arm. In addition, the sample preparation apparatus can include a tray for receiving pipette tips, receptacles for receiving tubes, an apparatus for forming an emulsion, a device for forming particles that include copies of the polynucleotide, a device for enriching the particles, as well as a centrifuge for loading such particles onto a sensor array. The sample preparation apparatus can further include receptacles for holding containers of reagent solutions.Type: ApplicationFiled: September 21, 2020Publication date: May 13, 2021Inventors: Kristopher BARBEE, Ryan JONES, Sean MCCUSKER, Maximilian CARPINO, John LEAMON, Jonathan SCHULTZ
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Publication number: 20210079464Abstract: Provided are systems and methods for analyte detection and analysis. A system can comprise an open substrate. The open substrate may be configured to rotate or otherwise move. The open substrate can comprise an array of individually addressable locations, with analytes immobilized thereto. The substrate may be spatially indexed to identify nucleic acid molecules from one or more sources, and/or sequences thereof, with the respective one or more sources. A solution comprising a plurality of probes may be directed across the array to couple at least one of the plurality of probes with at least one of the analytes to form a bound probe. A detector can be configured to detect a signal from the bound probe via scanning of the substrate while minimizing temperature fluctuations of the substrate or optical aberrations caused by bubbles.Type: ApplicationFiled: November 19, 2020Publication date: March 18, 2021Inventors: Nathan BECKETT, Gilad ALMOGY, Nathan CASWELL, Jacob A. WOLF, Kristopher BARBEE, Denis PRINTINSKI, Mark PRATT, Gene POLOVY, Osip SCHWARTZ, Stephanie KUBECKA, Steven MENCHEN, Joseph ANTHONY, Jose Martin SOSA, Phillip You Fai LEE
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Patent number: 10940490Abstract: A rotor assembly includes a rotor plate to rotate around a first axis; a bucket rotatably attached to the rotor plate and to rotate around a second axis; and a stop plate to rotate around the first axis relative to the rotor plate between an open position and a closed position, when in the closed position, the stop plate is to engage the bucket to fix an angular position of the bucket relative to a plane of rotation of the rotor assembly.Type: GrantFiled: December 3, 2018Date of Patent: March 9, 2021Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Kristopher Barbee, Rui Zheng, Sean McCusker
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Publication number: 20210054454Abstract: Provided are methods for biological sample processing and analysis. A method can comprise providing a substrate configured to rotate. The substrate can comprise an array having immobilized thereto a biological analyte. A solution comprising a plurality of probes may be directed, via centrifugal force, across the substrate during rotation of the substrate, to couple at least one of the plurality of probes with the biological analyte. A detector can be configured to detect a signal from the at least one probe coupled to the biological analyte, thereby analyzing the biological analyte.Type: ApplicationFiled: November 5, 2020Publication date: February 25, 2021Inventors: Gilad ALMOGY, Kristopher BARBEE, Nathan BECKETT