Patents by Inventor Kristopher M. Kirmess

Kristopher M. Kirmess has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Alpha-cyano-4-hydroxy-3-iodocinnamic acid as a matrix in MALDI mass spectrometry
    Patent number: 10464886
    Abstract: A heavy-atom derivative of CHCA, a primary matrix molecule for matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS), is synthesized and purified. This new matrix molecule ?-cyano-4-hydroxy-3-iodocinnamic acid (CHICA) is characterized by 1H NMR and mass spectrometry. CHICA is shown to increase MALDI-MS yield for the test analytes human angiotensin II and sex pheromone inhibitor as compared to both CHCA and an alternative heavy-atom CHCA derivative matrix. An optimal CHICA matrix concentration is determined to be 4 mg/mL. Analyte ion yield is shown to be comparable for CHICA and CHCA for analyte concentrations below 0.001 mg/mL. For analyte concentrations above this threshold, use of CHICA resulted in higher analyte yield and significantly lower relative standard deviation.
    Type: Grant
    Filed: November 27, 2018
    Date of Patent: November 5, 2019
    Assignee: Board of Trustees of Southern Illinois University
    Inventors: Kristopher M Kirmess, Gary R Kinsel, Kyle Newton Plunkett
  • Alpha-Cyano-4-Hydroxy-3-Iodocinnamic Acid as a Matrix in Maldi Mass Spectrometry
    Publication number: 20190161438
    Abstract: A heavy-atom derivative of CHCA, a primary matrix molecule for matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS), is synthesized and purified. This new matrix molecule ?-cyano-4-hydroxy-3-iodocinnamic acid (CHICA) is characterized by 1H NMR and mass spectrometry. CHICA is shown to increase MALDI-MS yield for the test analytes human angiotensin II and sex pheromone inhibitor as compared to both CHCA and an alternative heavy-atom CHCA derivative matrix. An optimal CHICA matrix concentration is determined to be 4 mg/mL. Analyte ion yield is shown to be comparable for CHICA and CHCA for analyte concentrations below 0.001 mg/mL. For analyte concentrations above this threshold, use of CHICA resulted in higher analyte yield and significantly lower relative standard deviation.
    Type: Application
    Filed: November 27, 2018
    Publication date: May 30, 2019
    Applicant: Board of Trustees of Southern IIIinois University
    Inventors: Kristopher M. Kirmess, Gary R. KINSEL, Kyle Newton PLUNKETT