Abstract: The disclosed adhesive compositions comprise (A) an isocyanate component comprising an isocyanate-terminated prepolymer that is the reaction product of a polyisocyanate and an isocyanate-reactive mixture comprising a phosphate ester polyol. The disclosed adhesive compositions further comprise (B) an isocyanate-reactive component polyol component comprising a polyol. In some embodiments, methods for preparing two-component adhesives formulations are disclosed comprising preparing an isocyanate component comprising an isocyanate-terminated prepolymer by reacting a polyisocyanate with an isocyanate-reactive mixture comprising a phosphate ester polyol and preparing an isocyanate-reactive component comprising a polyol. The methods further comprise mixing the isocyanate component and the isocyanate-reactive component at a stoichiometric ratio (NCO/OH) of from about 1.0 to about 5.0. Methods for forming laminate structures, and the laminate structures themselves, are also disclosed.

Abstract: The present technology relates to three-dimensional biomimetic platforms for culturing patient specific cells and tissues in biological material that closely recapitulates the native in vivo environment. The platforms of the present technology enable rapid and flexible biochemical, genomic, and metabolic analysis using a wide variety of assays, and live or end-point biological imaging.

Abstract: The present technology relates to methods for treating, preventing, and/or ameliorating cancer comprising administering a therapeutically effective amount of ghrelin, des-acyl ghrelin, or an analog thereof (e.g, the cyclic peptide analog AZP531) to a subject in need thereof. Kits for use in practicing the methods are also provided.

Abstract: The disclosed adhesive compositions comprise (A) an isocyanate component comprising an isocyanate-terminated prepolymer that is the reaction product of a polyisocyanate and an isocyanate-reactive mixture comprising a phosphate ester polyol. The disclosed adhesive compositions further comprise (B) an isocyanate-reactive component polyol component comprising a polyol. In some embodiments, methods for preparing two-component adhesives formulations are disclosed comprising preparing an isocyanate component comprising an isocyanate-terminated prepolymer by reacting a polyisocyanate with an isocyanate-reactive mixture comprising a phosphate ester polyol and preparing an isocyanate-reactive component comprising a polyol. The methods further comprise mixing the isocyanate component and the isocyanate-reactive component at a stoichiometric ratio (NCO/OH) of from about 1.0 to about 5.0. Methods for forming laminate structures, and the laminate structures themselves, are also disclosed.

Abstract: As described herein, a robust generalizable method to accurately and sensitively quantitate proteins in tissues and fluids from human patients in a direct manner, not reliant on antibody reagents has been developed. This provides new and robust methods that are useful as biochemical outcome measures in human clinical trials. The methods where mouse tissues fully labeled with stable isotopes are mixed with the human tissue of interest, and the mixture subjected to high throughput proteomics methods are provided. The method detects multiple protein peptides showing 100% conservation between human and mouse, and establishes test and control proteins for quantitation of surrogate biomarkers. This assay method provides a high degree of reliability and sensitivity, as well as generalizability, compared to more traditional antibody-based assays. The specific peptide pairs and methods of quantitation are also described.