Patents by Inventor Kristyna PIMKOVA

Kristyna PIMKOVA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of scientifically matched plant supplements combined with antineoplastic compounds for the treatment of hematological malignancies
    Patent number: 11478444
    Abstract: The present disclosure relates to the field of combination therapy for treatment of hematological malignancy selected from myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). The disclosure provides a combination therapy comprising plant based compounds and hypomethylating agent (HMA). Particularly, the disclosure provides a combination of: a) a therapeutically effective amount of a combination comprising sulforaphane, resveratrol and curcumin; and b) a therapeutically effective amount of HMA selected from azacitidine (AZA), decitabine (DEC) and a combination thereof, for treating MDS or AML. Said combination provides an enhanced/synergistic effect in the treatment of MDS or AML along with decreasing or overcoming resistance to HMA (azacitidine or decitabine). Methods for decreasing or overcoming resistance to HMA (azacitidine or decitabine), corresponding use of the above described combination and a kit comprising said combination are also provided.
    Type: Grant
    Filed: February 5, 2021
    Date of Patent: October 25, 2022
    Assignee: Brio Ventures
    Inventors: Shireen Vali, Taher Abbasi, Tomas Stopka, Lubomir Minarik, Neeraj Kumar Singh, Shahabuddin Usmani, Saumya Radhakrishnan, Huzaifa Sikora, Robinson Vidva, Kristyna Pimkova
  • USE OF SCIENTIFICALLY MATCHED PLANT SUPPLEMENTS COMBINED WITH ANTINEOPLASTIC COMPOUNDS FOR THE TREATMENT OF HEMATOLOGICAL MALIGNANCIES
    Publication number: 20210244703
    Abstract: The present disclosure relates to the field of combination therapy for treatment of hematological malignancy selected from myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). The disclosure provides a combination therapy comprising plant based compounds and hypomethylating agent (HMA). Particularly, the disclosure provides a combination of: a) a therapeutically effective amount of a combination comprising sulforaphane, resveratrol and curcumin; and b) a therapeutically effective amount of HMA selected from azacitidine (AZA), decitabine (DEC) and a combination thereof, for treating MDS or AML. Said combination provides an enhanced/synergistic effect in the treatment of MDS or AML along with decreasing or overcoming resistance to HMA (azacitidine or decitabine). Methods for decreasing or overcoming resistance to HMA (azacitidine or decitabine), corresponding use of the above described combination and a kit comprising said combination are also provided.
    Type: Application
    Filed: February 5, 2021
    Publication date: August 12, 2021
    Applicant: Brio Ventures, LLC
    Inventors: Shireen VALI, Taher ABBASI, Tomas STOPKA, Lubomir MINARIK, Neeraj Kumar SINGH, Shahabuddin USMANI, Saumya RADHAKRISHNAN, Huzaifa SIKORA, Robinson VIDVA, Kristyna PIMKOVA