Patents by Inventor Krisztina M. Zsebo

Krisztina M. Zsebo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for production of high titer virus and high efficiency retroviral mediated transduction of mammalian cells
    Patent number: 5858740
    Abstract: The invention provides a novel retroviral packaging system, in which retroviral packaging constructs and packagable vector transcripts are produced from high expression plasmids by transfection in human cells. High titers of recombinant retrovirus are produced in infected cells. The methods of the invention include the use of the novel retroviral constructs to transduce primary human cells, including T cells and human hematopoietic stem cells, with foreign genes by cocultivation at high efficiencies. The invention is useful for the rapid production of high viral supernatants, and to transduce with high efficiency cells that are refractory to transduction by conventional means.
    Type: Grant
    Filed: May 10, 1995
    Date of Patent: January 12, 1999
    Assignee: Cell Genesys, Inc.
    Inventors: Mitchell H. Finer, Margo R. Roberts, Thomas J. Dull, Krisztina M. Zsebo, Lu Qin, Deborah A. Farson
  • Method for production of high titer virus and high efficiency retroviral mediated transduction of mammalian cells
    Patent number: 5834256
    Abstract: The invention provides a novel retroviral packaging system, in which retroviral packaging constructs and packagable vector transcripts are produced from high expression plasmids by transfection in human cells. High titers of recombinant retrovirus are produced in infected cells. The methods of the invention include the use of the novel retroviral constructs to transduce primary human cells, including T cells and bone marrow stem cells, with foreign genes by cocultivation at high efficiencies. The invention is useful for the rapid production of high viral supernatants, and to transduce with high efficiency cells that are refractory to transduction by conventional means.
    Type: Grant
    Filed: June 11, 1993
    Date of Patent: November 10, 1998
    Assignee: Cell Genesys, Inc.
    Inventors: Mitchell H. Finer, Margo R. Roberts, Thomas J. Dull, Krisztina M. Zsebo, Lu Qin, Deborah A. Farson
  • Method for production of high titer virus and high efficiency retroviral mediated transduction of mammalian cells
    Patent number: 5686279
    Abstract: The invention provides a novel retroviral packaging system, in which retroviral packaging constructs and packagable vector transcripts are produced from high expression plasmids by transfection in human cells. High titers of recombinant retrovirus are produced in infected cells. The methods of the invention include the use of the novel retroviral constructs to transduce primary human cells, including T cells and human hematopoietic stem cells, with foreign genes by cocultivation at high efficiencies. The invention is useful for the rapid production of high viral supernatants, and to transduce with high efficiency cells that are refractory to transduction by conventional means.
    Type: Grant
    Filed: June 10, 1994
    Date of Patent: November 11, 1997
    Assignee: Cell Genesys, Inc.
    Inventors: Mitchell H. Finer, Margo R. Roberts, Thomas J. Dull, Krisztina M. Zsebo, Lu Qin, Deborah A. Farson