Abstract: A transseptal puncture system and method uses a guiding instrument, and an atraumatic puncture instrument longitudinally movable therein, with a first electrode configured for ablation and a second electrode electrically insulated from the first electrode. An impedance monitoring module is configured to measure at least an impedance at the second electrode, and an electrical generator is configured to selectively apply electrical energy to the first electrode based at least in part on the measured impedance at the second electrode. Moreover, impedance measurements at the first and second electrodes are used to determine relative positions of the instruments in the approach, contact, ablation and puncture of the septum.

Abstract: Provided herein are methods of generating T cells, e.g., cytotoxic T lymphocytes starting from peripheral blood mononuclear cells without a separate step of generating and isolating antigen-presenting cells, and with a single round of antigen stimulation. Also provided herein are methods of using said cytotoxic T lymphocytes, for example, to treat cancer and/or viral infection.

Abstract: A catheter with an electrode assembly has a functional electrode located at a first position on the electrode assembly and a shunting electrode located proximal to the first position. Irrigation fluid carried by the catheter may be electrically coupled with a patient's blood through the shunting electrode. The shunting electrode may be used to reduce noise in an electrocardiogram signal that results from the pump used to supply the irrigation fluid.

Abstract: Provided herein are methods of generating T cells, e.g., cytotoxic T lymphocytes starting from peripheral blood mononuclear cells without a separate step of generating and isolating antigen-presenting cells, and with a single round of antigen stimulation. Also provided herein are methods of using said cytotoxic T lymphocytes, for example, to treat cancer and/or viral infection.

Abstract: A console for performing a medical procedure has connection ports for electrically coupling equipment. Each connection port may have an associated indicator that signals whether a piece of equipment should be connected to the respective connection port. The indicators may be selectively activated depending on the procedure being performed with the console.

Abstract: The present disclosure relates to an integrated under-eye mask and makeup capture device. The device captures makeup fallout generated during application of makeup to the area around the eyes, and thereby prevents it from contaminating the area directly beneath the eye. The device simultaneously acts as an under-eye mask that delivers a dermatological composition comprising one or more skin active ingredients to the skin. The device comprises a deformable sheet-like substrate having a dry top surface for capturing makeup fallout, a moist bottom surface for application to the skin, and an upper edge that fits under an eye of a user, wherein the bottom moist surface is impregnated with a dermatological composition comprising one or more skin-active ingredients.

Abstract: A console for performing a medical procedure has connection ports for electrically coupling equipment. Each connection port may have an associated indicator that signals whether a piece of equipment should be connected to the respective connection port. The indicators may be selectively activated depending on the procedure being performed with the console.

Abstract: A catheter with an electrode assembly has a functional electrode located at a first position on the electrode assembly and a shunting electrode located proximal to the first position. Irrigation fluid carried by the catheter may be electrically coupled with a patient's blood through the shunting electrode. The shunting electrode may be used to reduce noise in an electrocardiogram signal that results from the pump used to supply the irrigation fluid.

Abstract: A catheterization system that includes an electrophysiologic (EP) catheter which has a lumen receiving an electrically conductive fluid delivered by a hydraulic line that is acted upon by a peristaltic pump advantageously avoids noise in intracardiac ECG signal recordings by using an electrical connection to short triboelectrical charge carried by the conductive fluid in the hydraulic line to an existing analog ground in the system. In one embodiment, the electrical connection includes an electrically conductive wire housed in the control handle and configured to provide electrical connection between the fluid and a pin on a printed circuit board housed in the control handle that is electrically connected to the analog ground. In another embodiment, the electrical connection shorts the electrically conductive fluid proximal of the control handle of the catheter.

Abstract: A catheterization system that includes an electrophysiologic (EP) catheter which has a lumen receiving an electrically conductive fluid delivered by a hydraulic line that is acted upon by a peristaltic pump advantageously avoids noise in intracardiac ECG signal recordings by using an electrical connection to short triboelectrical charge carried by the conductive fluid in the hydraulic line to an existing analog ground in the system. In one embodiment, the electrical connection includes an electrically conductive wire housed in the control handle and configured to provide electrical connection between the fluid and a pin on a printed circuit board housed in the control handle that is electrically connected to the analog ground. In another embodiment, the electrical connection shorts the electrically conductive fluid proximal of the control handle of the catheter.