Abstract: A messaging module is configured to, in response to a first indicator indicating that a patient has opted into receiving text messages, selectively send and receives text messages to and from a mobile phone number of the patient. A refill by text (RBT) module is configured to, when a second indicator indicates that the patient is not included in an RBT program, trigger the messaging module to send a predetermined text message to the mobile phone number in response to a determination that: a name of a prescription drug prescribed to the patient is included in a stored list of prescription drugs associated with the RBT program; the first indicator indicates that the patient has opted into receiving text messages; and a number of refills of the prescription drug already provided to the patient without a change in the therapy of the prescription drug is greater than a predetermined number.