Patents by Inventor Krystel R. Huxlin
Krystel R. Huxlin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230346602Abstract: A method for modifying a refractive property of ocular tissue in an eye by creating at least one optically-modified gradient index (GRIN) layer in the corneal stroma and/or the crystalline by continuously scanning a continuous stream of laser pulses having a focal volume from a laser having a known average power along a continuous line having a smoothly changing refractive index within the tissue, and varying either or both of the scan speed and the laser average power during the scan. The method may further involve determining a desired vision correction adjustment, and determining a position, number, and design parameters of gradient index (GRIN) layers to be created within the ocular tissue to provide the desired vision correction.Type: ApplicationFiled: May 17, 2023Publication date: November 2, 2023Inventors: Wayne H. Knox, Krystel R. Huxlin
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Patent number: 11690759Abstract: A method for modifying a refractive property of ocular tissue in an eye by creating at least one optically-modified gradient index (GRIN) layer in the corneal stroma and/or the crystalline by continuously scanning a continuous stream of laser pulses having a focal volume from a laser having a known average power along a continuous line having a smoothly changing refractive index within the tissue, and varying either or both of the scan speed and the laser average power during the scan. The method may further involve determining a desired vision correction adjustment, and determining a position, number, and design parameters of gradient index (GRIN) layers to be created within the ocular tissue to provide the desired vision correction.Type: GrantFiled: October 16, 2020Date of Patent: July 4, 2023Assignee: University of RochesterInventors: Wayne H. Knox, Krystel R. Huxlin
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Publication number: 20230149216Abstract: Refractive index writing system and methods employing a pulsed laser source for providing a pulsed laser output at a first wavelength; an objective lens for focusing the pulsed laser output to a focal spot in an optical material; a scanner for relatively moving the focal spot with respect to the optical material at a relative speed and direction along a scan region for writing one or more traces in the optical material defined by a change in refractive index; and a controller for controlling laser exposures along the one or more traces in accordance with a calibration function for the optical material to achieve a desired refractive index profile in the optical material. The refractive index writing system may be for writing traces in in vivo optical tissue, and the controller may be configured with a calibration function obtained by calibrating refractive index change induced in enucleated ocular globes.Type: ApplicationFiled: January 20, 2023Publication date: May 18, 2023Inventors: Wayne Knox, Jonathan D. Ellis, Krystel R. Huxlin, Daniel R. Brooks, Kaitlin T. Wozniak
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Patent number: 11571336Abstract: Refractive index writing system and methods employing a pulsed laser source for providing a pulsed laser output at a first wavelength; an objective lens for focusing the pulsed laser output to a focal spot in an optical material; a scanner for relatively moving the focal spot with respect to the optical material at a relative speed and direction along a scan region for writing one or more traces in the optical material defined by a change in refractive index; and a controller for controlling laser exposures along the one or more traces in accordance with a calibration function for the optical material to achieve a desired refractive index profile in the optical material. The refractive index writing system may be for writing traces in in vivo optical tissue, and the controller may be configured with a calibration function obtained by calibrating refractive index change induced in enucleated ocular globes.Type: GrantFiled: January 25, 2019Date of Patent: February 7, 2023Assignee: University of RochesterInventors: Wayne Knox, Jonathan D. Ellis, Krystel R. Huxlin, Daniel R. Brooks, Kaitlin T. Wozniak
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Publication number: 20210052425Abstract: Refractive index writing system and methods employing a pulsed laser source for providing a pulsed laser output at a first wavelength; an objective lens for focusing the pulsed laser output to a focal spot in an optical material; a scanner for relatively moving the focal spot with respect to the optical material at a relative speed and direction along a scan region for writing one or more traces in the optical material defined by a change in refractive index; and a controller for controlling laser exposures along the one or more traces in accordance with a calibration function for the optical material to achieve a desired refractive index profile in the optical material. The refractive index writing system may be for writing traces in in vivo optical tissue, and the controller may be configured with a calibration function obtained by calibrating refractive index change induced in enucleated ocular globes.Type: ApplicationFiled: January 25, 2019Publication date: February 25, 2021Inventors: Wayne Knox, Jonathan D. Ellis, Krystel R. Huxlin, Daniel R. Brooks, Kaitlin T. Wozniak
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Publication number: 20210045920Abstract: A method for modifying a refractive property of ocular tissue in an eye by creating at least one optically-modified gradient index (GRIN) layer in the corneal stroma and/or the crystalline by continuously scanning a continuous stream of laser pulses having a focal volume from a laser having a known average power along a continuous line having a smoothly changing refractive index within the tissue, and varying either or both of the scan speed and the laser average power during the scan. The method may further involve determining a desired vision correction adjustment, and determining a position, number, and design parameters of gradient index (GRIN) layers to be created within the ocular tissue to provide the desired vision correction.Type: ApplicationFiled: October 16, 2020Publication date: February 18, 2021Inventors: Wayne H. Knox, Krystel R. Huxlin
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Patent number: 10813791Abstract: A method for modifying a refractive property of ocular tissue in an eye by creating at least one optically-modified gradient index (GRIN) layer in the corneal stroma and/or the crystalline by continuously scanning a continuous stream of laser pulses having a focal volume from a laser having a known average power along a continuous line having a smoothly changing refractive index within the tissue, and varying either or both of the scan speed and the laser average power during the scan. The method may further involve determining a desired vision correction adjustment, and determining a position, number, and design parameters of gradient index (GRIN) layers to be created within the ocular tissue to provide the desired vision correction.Type: GrantFiled: December 15, 2011Date of Patent: October 27, 2020Assignee: University of RochesterInventors: Wayne H. Knox, Krystel R. Huxlin
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Publication number: 20190254875Abstract: A method for providing vision correction to a patient. The method includes: (a) measuring the degree of vision correction needed by the patient and determining the location and shape of refractive structures that need to be positioned within the cornea to partially correct a patient's vision; (b) directing and focusing femtosecond laser pulses in the blue spectral region within the cornea at an intensity high enough to change the refractive index of the cornea within a focal region, but not high enough to damage the cornea or to affect cornea tissue outside of the focal region; and (c) scanning the laser pulses across a volume of the cornea or the lens to provide the focal region with refractive structures in the cornea or the lens. Again, the refractive structures are characterized by a change in refractive index, and exhibit little or no scattering loss.Type: ApplicationFiled: April 29, 2019Publication date: August 22, 2019Inventors: Wayne H. Knox, Krystel R. Huxlin
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Patent number: 10271991Abstract: A method for providing vision correction to a patient. The method includes: (a) measuring the degree of vision correction needed by the patient and determining the location and shape of refractive structures that need to be positioned within the cornea to partially correct a patient's vision; (b) directing and focusing femtosecond laser pulses in the blue spectral region within the cornea at an intensity high enough to change the refractive index of the cornea within a focal region, but not high enough to damage the cornea or to affect cornea tissue outside of the focal region; and (c) scanning the laser pulses across a volume of the cornea or the lens to provide the focal region with refractive structures in the cornea or the lens. Again, the refractive structures are characterized by a change in refractive index, and exhibit little or no scattering loss.Type: GrantFiled: October 19, 2016Date of Patent: April 30, 2019Assignee: University of RochesterInventors: Wayne H. Knox, Krystel R. Huxlin
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Patent number: 10226381Abstract: By adapting femtosecond micromachining approaches developed in hydrogels, we can perform Intra-tissue Refractive Index Shaping (IRIS) in biological tissues. We reduced femtosecond laser pulse energies below the optical breakdown thresholds to create grating patterns that are associated with a change in the refractive index of the tissue. To increase two-photon absorption, we used a two (or more)-photon-absorbing chromophore.Type: GrantFiled: January 13, 2017Date of Patent: March 12, 2019Assignee: University of RochesterInventors: Wayne H. Knox, Krystel R. Huxlin, Li Ding
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Publication number: 20190046357Abstract: A laser system for changing the index of refraction of cornea tissue in a living eye. The laser system comprises a laser that provides laser pulses with a wavelength from 400 nm to 900 nm and a pulse energy from 0.01 nJ to 10 nJ, and a control device for setting the operating parameters of the laser below an optical breakdown threshold of the tissue to avoid photo-disruption and tissue destruction of the tissue, and to direct the laser pulses at the cornea tissue resulting in a change in the index of refraction of the tissue within regions irradiated by the laser pulses.Type: ApplicationFiled: October 17, 2018Publication date: February 14, 2019Inventors: Wayne H. Knox, Krystel R. Huxlin, Jay F. Kunzler, Li Ding
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Publication number: 20170156931Abstract: By adapting femtosecond micromachining approaches developed in hydrogels, we can perform Intra-tissue Refractive Index Shaping (IRIS) in biological tissues. We reduced femtosecond laser pulse energies below the optical breakdown thresholds to create grating patterns that are associated with a change in the refractive index of the tissue. To increase two-photon absorption, we used a two (or more)-photon-absorbing chromophore.Type: ApplicationFiled: January 13, 2017Publication date: June 8, 2017Inventors: Wayne H. Knox, Krystel R. Huxlin, Li Ding
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Publication number: 20170035613Abstract: A method for providing vision correction to a patient. The method includes: (a) measuring the degree of vision correction needed by the patient and determining the location and shape of refractive structures that need to be positioned within the cornea to partially correct a patient's vision; (b) directing and focusing femtosecond laser pulses in the blue spectral region within the cornea at an intensity high enough to change the refractive index of the cornea within a focal region, but not high enough to damage the cornea or to affect cornea tissue outside of the focal region; and (c) scanning the laser pulses across a volume of the cornea or the lens to provide the focal region with refractive structures in the cornea or the lens. Again, the refractive structures are characterized by a change in refractive index, and exhibit little or no scattering loss.Type: ApplicationFiled: October 19, 2016Publication date: February 9, 2017Inventors: Wayne H. Knox, Krystel R. Huxlin
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Patent number: 9545340Abstract: By adapting femtosecond micromachining approaches developed in hydrogels, we can perform Intra-tissue Refractive Index Shaping (IRIS) in biological tissues. We reduced femtosecond laser pulse energies below the optical breakdown thresholds to create grating patterns that are associated with a change in the refractive index of the tissue. To increase two-photon absorption, we used a two (or more)-photon-absorbing chromophore.Type: GrantFiled: September 9, 2008Date of Patent: January 17, 2017Assignee: University of RochesterInventors: Wayne H. Knox, Krystel R. Huxlin, Li Ding
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Patent number: 9492323Abstract: A method for providing vision correction to a patient. The method includes: (a) measuring the degree of vision correction needed by the patient and determining the location and shape of refractive structures that need to be positioned within the cornea to partially correct a patient's vision; (b) directing and focusing femtosecond laser pulses in the blue spectral region within the cornea at an intensity high enough to change the refractive index of the cornea within a focal region, but not high enough to damage the cornea or to affect cornea tissue outside of the focal region; and (c) scanning the laser pulses across a volume of the cornea or the lens to provide the focal region with refractive structures in the cornea or the lens. Again, the refractive structures are characterized by a change in refractive index, and exhibit little or no scattering loss.Type: GrantFiled: December 17, 2013Date of Patent: November 15, 2016Assignee: University of RochesterInventors: Wayne H. Knox, Krystel R. Huxlin
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Publication number: 20140107632Abstract: A method for providing vision correction to a patient. The method includes: (a) measuring the degree of vision correction needed by the patient and determining the location and shape of refractive structures that need to be positioned within the cornea to partially correct a patient's vision; (b) directing and focusing femtosecond laser pulses in the blue spectral region within the cornea at an intensity high enough to change the refractive index of the cornea within a focal region, but not high enough to damage the cornea or to affect cornea tissue outside of the focal region; and (c) scanning the laser pulses across a volume of the cornea or the lens to provide the focal region with refractive structures in the cornea or the lens. Again, the refractive structures are characterized by a change in refractive index, and exhibit little or no scattering loss.Type: ApplicationFiled: December 17, 2013Publication date: April 17, 2014Applicant: UNIVERSITY OF ROCHESTERInventors: Wayne H. Knox, Krystel R. Huxlin
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Patent number: 8617147Abstract: A method for providing vision correction to a patient. The method includes: (a) measuring the degree of vision correction needed by the patient and determining the location and shape of refractive structures that need to be positioned within the cornea to partially correct a patient's vision; (b) directing and focusing femtosecond laser pulses in the blue spectral region within the cornea at an intensity high enough to change the refractive index of the cornea within a focal region, but not high enough to damage the cornea or to affect cornea tissue outside of the focal region; and (c) scanning the laser pulses across a volume of the cornea or the lens to provide the focal region with refractive structures in the cornea or the lens. Again, the refractive structures are characterized by a change in refractive index, and exhibit little or no scattering loss.Type: GrantFiled: October 1, 2010Date of Patent: December 31, 2013Assignee: University of RochesterInventors: Wayne H. Knox, Krystel R. Huxlin
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Patent number: 8512320Abstract: The invention is directed to a method for correcting vision in a patient by modifying the refractive index of cornea tissue. The method comprises identifying and measuring the degree of vision correction of the patient; and determining the position and type of refractive structures to be written into the cornea tissue of the patient to correct the patient's vision. The refractive structures are written by irradiating select regions of the cornea tissue with focused laser pulses having a wavelength from 400 nm to 900 nm and a pulse energy from 0.01 nJ to 10 nJ. The refractive structures are characterized by a positive change in refractive index in relation to non-irradiated cornea tissue of the patient.Type: GrantFiled: March 8, 2013Date of Patent: August 20, 2013Assignees: Bausch & Lomb Incorporated, University of RochesterInventors: Wayne H. Knox, Krystel R. Huxlin, Jay F. Kunzler, Li Ding
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Patent number: 8486055Abstract: A method for modifying the refractive index of ocular tissues. The method comprises irradiating select regions of ocular tissue with a visible or near-IR laser. The irradiation results in the formation of structures in the ocular tissue, characterized by a change in refractive index, and which exhibit little or no scattering loss.Type: GrantFiled: June 26, 2008Date of Patent: July 16, 2013Assignees: Bausch & Lomb Incorporated, University of RochesterInventors: Wayne H. Knox, Li Ding, Krystel R. Huxlin, Jay F. Kunzler
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Publication number: 20120310223Abstract: A method for modifying a refractive property of ocular tissue in an eye by creating at least one optically-modified gradient index (GRIN) layer in the corneal stroma and/or the crystalline by continuously scanning a continuous stream of laser pulses having a focal volume from a laser having a known average power along a continuous line having a smoothly changing refractive index within the tissue, and varying either or both of the scan speed and the laser average power during the scan. The method may further involve determining a desired vision correction adjustment, and determining a position, number, and design parameters of gradient index (GRIN) layers to be created within the ocular tissue to provide the desired vision correction.Type: ApplicationFiled: December 15, 2011Publication date: December 6, 2012Applicant: UNIVERSITY OF ROCHESTERInventors: Wayne H. Knox, Krystel R. Huxlin