Patents by Inventor Krystyna Lesiak

Krystyna Lesiak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Dermatological compositions and methods
    Patent number: 7250157
    Abstract: Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin and proliferative disorders; by administration of various compounds, including alcohols, diols and/or triols and their analogues.
    Type: Grant
    Filed: October 14, 2005
    Date of Patent: July 31, 2007
    Assignee: Applied Genetics Incorporated Dermatics
    Inventors: David A. Brown, Alexander A. Khorlin, Krystyna Lesiak, Wu Yun Ren
  • Dermatological compositions and methods
    Publication number: 20060120976
    Abstract: Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin and proliferative disorders; by administration of various compounds, including alcohols, diols and/or triols and their analogues.
    Type: Application
    Filed: October 14, 2005
    Publication date: June 8, 2006
    Applicant: Applied Genetics Incorporated Dermatics
    Inventors: David Brown, Alexander Khorlin, Krystyna Lesiak, Wu Ren
  • Dermatological compositions and methods
    Patent number: 6955804
    Abstract: Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin and proliferative disorders; by administration of various compounds, including alcohols, diols and/or triols and their analogues.
    Type: Grant
    Filed: September 22, 2003
    Date of Patent: October 18, 2005
    Assignee: Applied Genetics Incorporated Dematics
    Inventors: David A. Brown, Alexander A. Khorlin, Krystyna Lesiak, Wu Yun Ren
  • Tetraphosphonate bicyclic trisanhydrides
    Publication number: 20040181078
    Abstract: Disclosed are novel bicyclic tris(anhydride)s useful as intermediates in the synthesis of biologically active compounds, and the compounds which may be synthesized from such intermediates.
    Type: Application
    Filed: March 29, 2004
    Publication date: September 16, 2004
    Applicant: Pharmasset, Ltd.
    Inventors: Krzysztof W. Pankiewicz, Krystyna Lesiak, Kyoichi A. Watanabe
  • Dermatological compositions and methods
    Publication number: 20040067209
    Abstract: Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin and proliferative disorders; by administration of various compounds, including alcohols, diols and/or triols and their analogues.
    Type: Application
    Filed: September 22, 2003
    Publication date: April 8, 2004
    Applicant: Applied Genetics Incorporated Dermatics
    Inventors: David A. Brown, Alexander A. Khorlin, Krystyna Lesiak, Wu Yun Ren
  • Tetraphosphonate bicyclic trisanhydrides
    Patent number: 6713623
    Abstract: Disclosed are novel bicyclic tris(anhydride)s useful as intermediates in the synthesis of biologically active compounds, and the compounds which may be synthesized from such intermediates.
    Type: Grant
    Filed: November 13, 2001
    Date of Patent: March 30, 2004
    Assignee: Pharmasset, Ltd.
    Inventors: Krzysztof W. Pankiewicz, Krystyna Lesiak, Kyoichi A. Watanabe
  • Dermatological compositions and methods
    Patent number: 6623724
    Abstract: Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin and proliferative disorders; by administration of various compounds, including alcohols, diodls and/or triols and their analogues.
    Type: Grant
    Filed: May 28, 1998
    Date of Patent: September 23, 2003
    Assignee: Applied Genetics Incorporated Dermatics
    Inventors: David A. Brown, Alexander A. Khorlin, Krystyna Lesiak, Wu Yun Ren
  • Tetraphosphonate bicyclic trisanhydrides
    Publication number: 20020161220
    Abstract: Disclosed are novel bicyclic tris(anhydride)s useful as intermediates in the synthesis of biologically active compounds, and the compounds which may be synthesized from such intermediates.
    Type: Application
    Filed: November 13, 2001
    Publication date: October 31, 2002
    Inventors: Krzysztof W. Pankiewicz, Krystyna Lesiak, Kyoichi A. Watanabe
  • DERMATOLOGICAL COMPOSITIONS AND METHODS
    Publication number: 20020141952
    Abstract: Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin and proliferative disorders; by administration of various compounds, including alcohols, diols and/or triols and their analogues.
    Type: Application
    Filed: May 28, 1998
    Publication date: October 3, 2002
    Inventors: DAVID A. BROWN, ALEXANDER A. KHORLIN, KRYSTYNA LESIAK, WU YUN REN
  • Tetraphosphonate bicyclic trisanhydrides
    Patent number: 6326490
    Abstract: Disclosed are novel bicyclic tris(anhydride)s useful as intermediates in the synthesis of biolologically active compounds, and the compounds which may be synthesized from such intermediates.
    Type: Grant
    Filed: October 10, 1997
    Date of Patent: December 4, 2001
    Assignee: Pharmasset, Ltd.
    Inventors: Krzysztof W. Pankiewicz, Krystyna Lesiak, Kyoichi A. Watanabe
  • Dermatological compositions and methods
    Patent number: 6290937
    Abstract: Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin and proliferative disorders; by administration of various compounds, including alcohols, diols and/or triols and their analogues.
    Type: Grant
    Filed: May 28, 1998
    Date of Patent: September 18, 2001
    Assignee: Applied Genetics Incorporated Dermatics
    Inventors: David A. Brown, Alexander A. Khorlin, Krystyna Lesiak, Wu Yun Ren
  • Chimeric molecules targeted to viral RNAs
    Patent number: 6271369
    Abstract: Chimeric molecules comprising a virus targeting antisense oligonucleotide moiety attached to an activator of 2-5A-dependent RNase.
    Type: Grant
    Filed: October 14, 1997
    Date of Patent: August 7, 2001
    Assignees: The United States of America as represented by the Department of Health and Human Services, The Cleveland Clinic Foundation
    Inventors: Paul F. Torrence, Robert H. Silverman, Ratan K. Maitra, Krystyna Lesiak
  • Method of cleaving specific strands of RNA and medical treatments thereby
    Patent number: 5677289
    Abstract: A method of using a chimeric molecule made up of an antisense oligonucleotide attached to a 2',5'-oligoadenylate molecule to specifically cleave a sense strand of RNA, wherein the antisense oligonucleotide of the chimeric molecule is hybridized to the sense strand of RNA in the presence of 2',5'-dependent RNase.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: October 14, 1997
    Assignees: The Cleveland Clinic Foundation, The United States of America
    Inventors: Paul Torrence, Robert Silverman, Ratan Maitra, Krystyna Lesiak
  • Method of cleaving specific strands of RNA
    Patent number: 5583032
    Abstract: A method of using a chimeric molecule made up of an antisense oligonucleotide attached to a 2',5'-oligoadenylate molecule to specifically cleave a sense strand of RNA, wherein the antisense oligonucleotide of the chimeric molecule is hybridized to the sense strand of RNA in the presence of 2',5'-dependent RNase.
    Type: Grant
    Filed: September 17, 1993
    Date of Patent: December 10, 1996
    Assignee: The Cleveland Clinic Foundation and National Institutes of Health
    Inventors: Paul Torrence, Robert Silverman, Ratan Maitra, Krystyna Lesiak