Patents by Inventor Krystyna Skupinska

Krystyna Skupinska has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CXCR4 chemokine receptor binding compounds
    Patent number: 7863293
    Abstract: The present invention relates to compounds that bind to chemokine receptors, and having the formula wherein each A, X, Y, R1, R2 and R3 are substituents. The present invention also relates to methods of using such compounds, such as in treating HIV infection and inflammatory conditions such as rheumatoid arthritis. Furthermore, the present invention relates to methods to elevate progenitor and stem cell counts, as well as methods to elevate white blood cell counts, using such compounds.
    Type: Grant
    Filed: November 6, 2007
    Date of Patent: January 4, 2011
    Assignee: Genzyme Corporation
    Inventors: Gary J. Bridger, Ernest J. McEachern, Renato Skerlj, Dominique Schols, Ian Baird, Al Kaller, Curtis Harwig, Yongbao Zhu, Gang Chen, Krystyna Skupinska
  • CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS WITH ENHANCED EFFICACY
    Publication number: 20090281308
    Abstract: Compounds that interact with the CXCR4 receptor are described. These compounds are useful in treating, for Example, HIV infection and inflammatory conditions such as rheumatoid arthritis, as well as asthma or cancer, and are useful in methods to elevate progenitor and stem cell counts as well as methods to elevate white blood cell counts.
    Type: Application
    Filed: May 15, 2009
    Publication date: November 12, 2009
    Inventors: Gary J. BRIDGER, Ernest J. MCEACHERN, Renato SKERLJ, Dominique SCHOLS, Ian BAIRD, Al KALLER, Curtis HARWIG, Yongbao ZHU, Gang CHEN, Krystyna SKUPINSKA, Markus METZ
  • Chemokine receptor binding heterocyclic compounds with enhanced efficacy
    Patent number: 7550484
    Abstract: Compounds that interact with the CXCR4 receptor are described. These compounds are useful in treating, for Example, HIV infection and inflammatory conditions such as rheumatoid arthritis, as well as asthma or cancer, and are useful in methods to elevate progenitor and stem cell counts as well as methods to elevate white blood cell counts.
    Type: Grant
    Filed: April 22, 2004
    Date of Patent: June 23, 2009
    Assignee: Genzyme Corporation
    Inventors: Gary J. Bridger, Ernest J. McEachern, Renato Skerlj, Dominique Schols, Ian Baird, Al Kaller, Curtis Harwig, Yongbao Zhu, Gang Chen, Krystyna Skupinska, Markus Metz
  • Synthesis of enantiomerically pure amino-substituted fused bicyclic rings
    Patent number: 7452994
    Abstract: This invention describes various processes for synthesis and resolution of racemic amino-substituted fused bicyclic ring systems. One process utilizes selective hydrogenation of an amino-substituted fused bicyclic aromatic ring system. An alternative process prepares the racemic amino-substituted fused bicyclic ring system via nitrosation. In addition, the present invention describes the enzymatic resolution of a racemic mixture to produce the (R)- and (S)-forms of amino-substituted fused bicyclic rings as well as a racemization process to recycle the unpreferred enantioner. Further provided by this invention is an asymmetric synthesis of the (R)- or (S)-enantiomer of primary amino-substituted fused bicyclic ring systems.
    Type: Grant
    Filed: November 14, 2006
    Date of Patent: November 18, 2008
    Assignee: Anormed, Inc.
    Inventors: Ernest J. McEachern, Gary J. Bridger, Krystyna A. Skupinska, Renato T. Skerlj, Wen Yang
  • CXCR4 CHEMOKINE RECEPTOR BINDING COMPOUNDS
    Publication number: 20080255197
    Abstract: The present invention relates to compounds that bind to chemokine receptors, and having the formula wherein each A, X, Y, R1, R2 and R3 are substituents. The present invention also relates to methods of using such compounds, such as in treating HIV infection and inflammatory conditions such as rheumatoid arthritis. Furthermore, the present invention relates to methods to elevate progenitor and stem cell counts, as well as methods to elevate white blood cell counts, using such compounds.
    Type: Application
    Filed: November 6, 2007
    Publication date: October 16, 2008
    Inventors: Gary J. BRIDGER, Ernest J. McEachern, Renato Skerlj, Dominique Schols, Ian Baird, Al Kaller, Curtis Harwig, Yongbao Zhu, Gang Chen, Krystyna Skupinska
  • CXCR4 chemokine receptor binding compounds
    Patent number: 7291631
    Abstract: The present invention relates to compounds that bind to chemokine receptors, and having the formula wherein each A, X, Y, R1, R2 and R3 are substituents. The present invention also relates to methods of using such compounds, such as in treating HIV infection and inflammatory conditions such as rheumatoid arthritis. Furthermore, the present invention relates to methods to elevate progenitor and stem cell counts, as well as methods to elevate white blood cell counts, using such compounds.
    Type: Grant
    Filed: April 12, 2004
    Date of Patent: November 6, 2007
    Assignee: Genzyme Corporation
    Inventors: Gary J. Bridger, Ernest J. McEachern, Renato Skerlj, Dominique Schols, Ian Baird, Al Kaller, Curtis Harwig, Yongbao Zhu, Gang Chen, Krystyna Skupinska
  • Synthesis of enantiomerically pure amino-substituted fused bicyclic rings
    Publication number: 20070060757
    Abstract: This invention describes various processes for synthesis and resolution of racemic amino-substituted fused bicyclic ring systems. One process utilizes selective hydrogenation of an amino-substituted fused bicyclic aromatic ring system. An alternative process prepares the racemic amino-substituted fused bicyclic ring system via nitrosation. In addition, the present invention describes the enzymatic resolution of a racemic mixture to produce the (R)- and (S)-forms of amino-substituted fused bicyclic rings as well as a racemization process to recycle the unpreferred enantioner. Further provided by this invention is an asymmetric synthesis of the (R)- or (S)-enantiomer of primary amino-substituted fused bicyclic ring systems.
    Type: Application
    Filed: November 14, 2006
    Publication date: March 15, 2007
    Applicant: AnorMED Inc.
    Inventors: Ernest McEachern, Gary Bridger, Krystyna Skupinska, Renato Skerlj, Wen Yang
  • Synthesis of enantiomerically pure amino-substituted fused bicyclic rings
    Patent number: 7135570
    Abstract: This invention describes various processes for synthesis and resolution of racemic amino-substituted fused bicyclic ring systems. One process utilizes selective hydrogenation of an amino-substituted fused bicyclic aromatic ring system. An alternative process prepares the racemic amino-substituted fused bicyclic ring system via nitrosation. In addition, the present invention describes the enzymatic resolution of a racemic mixture to produce the (R)— and (S)— forms of amino-substituted fused bicyclic rings as well as a racemization process to recycle the unpreferred enantioner. Further provided by this invention is an asymmetric synthesis of the (R)— or (S)— enantiomer of primary amino-substituted fused bicyclic ring systems.
    Type: Grant
    Filed: October 6, 2004
    Date of Patent: November 14, 2006
    Assignee: Anormed Inc.
    Inventors: Ernest J. McEachern, Gary J. Bridger, Krystyna A. Skupinska, Renato T. Skerlj, Wen Yang
  • Synthesis of enantiomerically pure amino-substituted fused bicyclic rings
    Publication number: 20050080267
    Abstract: This invention describes various processes for synthesis and resolution of racemic amino-substituted fused bicyclic ring systems. One process utilizes selective hydrogenation of an amino-substituted fused bicyclic aromatic ring system. An alternative process prepares the racemic amino-substituted fused bicyclic ring system via nitrosation. In addition, the present invention describes the enzymatic resolution of a racemic mixture to produce the (R)- and (S)-forms of amino-substituted fused bicyclic rings as well as a racemization process to recycle the unpreferred enantioner. Further provided by this invention is an asymmetric synthesis of the (R)- or (S)-enantiomer of primary amino-substituted fused bicyclic ring systems.
    Type: Application
    Filed: October 6, 2004
    Publication date: April 14, 2005
    Applicant: AnorMED, Inc.
    Inventors: Ernest McEachern, Gary Bridger, Krystyna Skupinska, Renato Skerlj
  • Chemokine receptor binding heterocyclic compounds with enhanced efficacy
    Publication number: 20050059702
    Abstract: Compounds that interact with the CXCR4 receptor are described. These compounds are useful in treating, for Example, HIV infection and inflammatory conditions such as rheumatoid arthritis, as well as asthma or cancer, and are useful in methods to elevate progenitor and stem cell counts as well as methods to elevate white blood cell counts.
    Type: Application
    Filed: April 22, 2004
    Publication date: March 17, 2005
    Inventors: Gary Bridger, Ernest Mceachern, Renato Skerlj, Dominique Schols, Ian Baird, Ai Kaller, Curtis Harwig, Yongbao Zhu, Gang Chen, Krystyna Skupinska, Markus Metz
  • Synthesis of enantiomerically pure amino-substituted fused bicyclic rings
    Patent number: 6825351
    Abstract: This invention describes various processes for synthesis and resolution of racemic amino-substituted fused bicyclic ring systems. One process utilizes selective hydrogenation of an amino-substituted fused bicyclic aromatic ring system. An alternative process prepares the racemic amino-substituted fused bicyclic ring system via nitrosation. In addition, the present invention describes the enzymatic resolution of a racemic mixture to produce the (R)- and (S)-forms of amino-substituted fused bicyclic rings as well as a racemization process to recycle the unpreferred enantioner. Further provided by this invention is an asymmetric synthesis of the (R)- or (S)-enantiomer of primary amino-substituted fused bicyclic ring systems.
    Type: Grant
    Filed: September 12, 2002
    Date of Patent: November 30, 2004
    Assignee: Anormed, Inc.
    Inventors: Ernest J. McEachern, Gary J. Bridger, Krystyna Skupinska, Renato T. Skerlj
  • Synthesis of enantiomerically pure amino-substituted fused bicyclic rings
    Publication number: 20030114679
    Abstract: This invention describes various processes for synthesis and resolution of racemic amino-substituted fused bicyclic ring systems. One process utilizes selective hydrogenation of an amino-substituted fused bicyclic aromatic ring system. An alternative process prepares the racemic amino-substituted fused bicyclic ring system via nitrosation. In addition, the present invention describes the enzymatic resolution of a racemic mixture to produce the (R)- and (S)-forms of amino-substituted fused bicyclic rings as well as a racemization process to recycle the unpreferred enantioner. Further provided by this invention is an asymmetric synthesis of the (R)- or (S)-enantiomer of primary amino-substituted fused bicyclic ring systems.
    Type: Application
    Filed: September 12, 2002
    Publication date: June 19, 2003
    Inventors: Ernest J. McEachern, Gary J. Bridger, Krystyna A. Skupinska, Renato T. Skerlj