Patents by Inventor Krzystof W. Pankiewicz

Krzystof W. Pankiewicz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Analogues of adenosine 5'diphosphate and pharmaceutical compositions thereof
    Patent number: 5700786
    Abstract: This invention provides a compound having the structure: ##STR1## wherein R.sup.1, R.sup.2, and R.sup.3 are same or different, and are hydrogen, hydroxyl, or fluorine; Z is O, CH.sub.2 or CF.sub.2 ; R is chlorine, bromine, iodine, carbonitrile, carboxylic ester, or carboxamide; and one of W, X and Y is N or N.sup.+ R', wherein R' is methyl or ethyl, and all others are CH; provided that R.sup.1 is not H when R.sup.2 and R.sup.3 are OH, Z is O, R is carboxamide and W is N or N.sup.+ R'.This invention also provides methods of preparing the compounds and a method of treating a mammal having a NAD-dependent enzyme associated disorder.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 23, 1997
    Assignees: Sloan-Kettering Institute for Cancer Research, The University of Rochester
    Inventors: Kyoichi A. Watanabe, Krzystof W. Pankiewicz, Barry M. Goldstein, J. Ellis Bell
  • C-nucleoside isosters of analogs thereof and pharmaceutical compositions
    Patent number: 5569650
    Abstract: This invention provides a compound having the structure: ##STR1## wherein R.sup.1, R.sup.2, and R.sup.3 are same or different, and are hydrogen, hydroxyl, or fluorine; Z is O, CH.sub.2 or CF.sub.2 ; R is chlorine, bromine, iodine, carbonitrile, carboxylic ester, or carboxamide; and one of W, X and Y is N or N.sup.+ R', wherein R' is methyl or ethyl, and all others are CH; provided that R.sup.1 is not H when R.sup.2 and R.sup.3 are OH, Z is O, R is carboxamide and W is N or N.sup.+ R'.This invention also provides methods of preparing the compounds and a method of treating a mammal having a NAD-dependent enzyme associated disorder.
    Type: Grant
    Filed: June 11, 1993
    Date of Patent: October 29, 1996
    Assignees: Sloan-Kettering Institute for Cancer Research, The University of Rochester
    Inventors: Kyoichi A. Watanabe, Krzystof W. Pankiewicz, Barry M. Goldstein, J. Ellis Bell