Abstract: A system and method is disclosed for integrating and accessing multiple data sources within a data warehouse architecture. The metadata formed by the present method provide a way to declaratively present domain specific knowledge, obtained by analyzing data sources, in a consistent and useable way. Four types of information are represented by the metadata: abstract concepts, databases, transformations and mappings. A mediator generator automatically generates data management computer code based on the metadata. The resulting code defines a translation library and a mediator class. The translation library provides a data representation for domain specific knowledge represented in a data warehouse, including “get” and “set” methods for attributes that call transformation methods and derive a value of an attribute if it is missing. The mediator class defines methods that take “distinguished” high-level objects as input and traverse their data structures and enter information into the data warehouse.

Abstract: Information about a protein is produced by a number of steps including: Developing a specification of how local descriptors of protein structure are defined. Developing a local descriptors of protein structure database including calculated descriptors. Developing a definition of inter-descriptor similarity measure. Developing a local descriptors of protein structure class database of descriptors organized by their similarity. Producing information about any protein by analyzing said protein using the local descriptors of protein structure class database of descriptors organized by their similarity.