Patents by Inventor Krzysztof Dziewiszek

Krzysztof Dziewiszek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Lipid platinum complexes and methods of use thereof
    Publication number: 20070160656
    Abstract: This invention provides novel lipid platinum complexes, liposomally encapsulated lipid platinum complexes, pharmaceutical compositions comprising a lipid platinum complex, and methods for treating cancer using a lipid platinum complex. Kits comprising a unit dosage form of a compound or composition of the invention are also provided.
    Type: Application
    Filed: May 3, 2004
    Publication date: July 12, 2007
    Inventors: Krzysztof Dziewiszek, Alemseged Truneh
  • Methods and compositions for the manufacture of halogenated anthracyclines with increased antitumor activity, other anthracyclines, halogenated sugars, and glycosyl donors
    Patent number: 6355784
    Abstract: The present invention discloses new and novel halogenated anthracyclines linked through the saccharide portions. These congeners show high activity in vitro against several tumor cell lines. In doxorubicin (DOX) sensitive cell lines, they are at least as cytotoxic as DOX and in some cases more so. Many of these 4′- and 6′-fluorinated anthracyclines are more effective against multidrug-resistant tumors than was DOX, and/or have greater effectiveness than DOX against DOX sensitive cells. The compounds of this invention also have anti-amyloidogenic effects and the use of these compounds in the treatment of Alzheimer's disease is contemplated.
    Type: Grant
    Filed: June 10, 1999
    Date of Patent: March 12, 2002
    Inventors: Waldemar Priebe, Marta Krawczyk, Piotr Skibicki, Izabela Fokt, Krzysztof Dziewiszek, Grzegorz Grynkiewicz, Roman Perez-Soler
  • Synthesis of annamycin
    Patent number: 5977327
    Abstract: An improved method for synthesis of Annamycin is described. The synthesis relies upon a method of selectively deacetylating the Annamycin precursor and purification of the deacetylated product by a filtration step. In addition, the method includes an improved method for desilylating the Annamycin precursor that utilizes acidic conditions. Lastly, improved purification methods of the final Annamycin product are disclosed.
    Type: Grant
    Filed: July 22, 1997
    Date of Patent: November 2, 1999
    Assignee: Board of Regents, The University of Texas System
    Inventors: Krzysztof Dziewiszek, Waldemar Priebe