Patents by Inventor Krzysztof Kobielak

Krzysztof Kobielak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SWEAT GLAND-DERIVED STEM CELLS AND METHODS OF USE
    Publication number: 20160075995
    Abstract: Provided herein is a method to isolate a sweat gland stem cell and novel compositions containing the cell. Also provided are compositions and methods to clonally expand the population and differentiate the cells into various phenotypes. Therapeutic methods for the compositions are further provided.
    Type: Application
    Filed: September 16, 2015
    Publication date: March 17, 2016
    Inventor: Krzysztof Kobielak
  • HAIR FOLLICLE STEM CELLS AND METHODS OF USE SAME
    Publication number: 20150033371
    Abstract: The disclosure provides isolated hair follicle stem cells (hfSC) having inactivated BMP signaling, which are discovered to express keratin 15. Also provided are hfSC that have constitutively activated BMP signaling and methods of using such hfSC for screening candidate agents suitable for inhibiting BMP signaling in hfSC and promoting hair growth. Further provided are methods of activating hfSC and promoting hair growth from hfSC.
    Type: Application
    Filed: September 13, 2012
    Publication date: January 29, 2015
    Applicant: University of Southern California
    Inventors: Krzysztof Kobielak, Eve Kandyba
  • Method for Modulating Epithelial Stem Cell Lineage
    Publication number: 20120034616
    Abstract: The present invention relates to methods of modulating epithelial stem cell lineage by regulating the expression of Lef1 or a BMP inhibitor and/or the stability of ?-catenin or the expression of a Wnt; regulating the expression or activity of GATA-3; or regulating BMPR1A activity either at the level of receptor expression or at the level of pathway activation. Methods of regulating E-cadherin, GATA-3, BMPR1A and HK1-hair keratin and methods of identifying agents which modulate the epithelial stem cell lineage are further provided. Such agents are useful for inhibiting or stimulating inner root sheath development or hair follicle formation.
    Type: Application
    Filed: September 30, 2010
    Publication date: February 9, 2012
    Applicant: The Rockefeller University
    Inventors: Elaine Fuchs, Colin Jamora, Charles K. Kaufman, Krzysztof Kobielak
  • Method for modulating epithelial stem cell lineage
    Publication number: 20060172304
    Abstract: The present invention relates to methods of modulating epithelial stem cell lineage by regulating the expression of Lef1 or a BMP inhibitor and/or the stability of ?-catenin or the expression of a Wnt; regulating the expression or activity of GATA-3; or regulating BMPR1A activity either at the level of receptor expression or at the level of pathway activation. Methods of regulating E-cadherin, GATA-3, BMPR1A and HK1-hair keratin and methods of identifying agents which modulate the epithelial stem cell lineage are further provided. Such agents are useful for inhibiting or stimulating inner root sheath development or hair follicle formation.
    Type: Application
    Filed: February 27, 2004
    Publication date: August 3, 2006
    Inventors: Elaine Fuchs, Colin Jamora, Charles Kaufman, Krzysztof Kobielak