Patents by Inventor Krzysztof Wypijewski

Krzysztof Wypijewski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INHIBITION OF GENE EXPRESSION
    Publication number: 20100173407
    Abstract: There is provided a method of inhibiting gene expression by locating a 5?-5 donor splicing site sequence in the 3? UTR of a gene or within coding sequence containing the stop codon of a gene. Stability of homologous mRNA in trans is also adversely affected leading to a reduction in expression. A polynucleotide containing a 5?-donor splicing site sequence in either coding sequence containing the stop codon or the 3? UTR is also provided and in one embodiment is in the form of a vector. The 5?-donor splicing site sequence can be present in multiple copies, for example as a tandem repeat. In one embodiment the 5-donor splicing site sequence has the sequence 5?-MAGGTRAGTA-3? where M is A or C and R is A or G.
    Type: Application
    Filed: January 30, 2008
    Publication date: July 8, 2010
    Applicant: SCOTTISH CROP RESEARCH INSTITUTE
    Inventors: Krzysztof Wypijewski, Christophe Lacomme, Gyorgy Hutvagner, Csaba Hornyik, Jane Shaw, Jennifer Stephens