Patents by Inventor Ksenia GNEDEVA

Ksenia GNEDEVA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PYRROLO[2,3-b]PYRIDINE-3-CARBOXAMIDE COMPOSITIONS AND METHODS FOR AMELIORATING HEARING LOSS
    Publication number: 20230137893
    Abstract: N-(3-Substituted thiazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamides and N-(3-substituted oxazol-2(3H)-ylidene)-1H-pyrrolo[2,3-b]pyridine-3-carboxamides are disclosed. The compounds activate Yap and inhibit Lats kinases. They are therefore useful for treating hearing loss.
    Type: Application
    Filed: February 5, 2021
    Publication date: May 4, 2023
    Applicant: The Rockefeller University
    Inventors: Ksenia GNEDEVA, A. James HUDSPETH, Nathaniel KASTAN, Rui LIANG, Peter T. MEINKE, David John HUGGINS, Nigel John LIVERTON, Leigh Ashley BAXT, John David GINN, Robert Walter MYERS
  • ACTIVATION OF YAP SIGNALING FOR SENSORY RECEPTOR REGENERATION
    Publication number: 20210324412
    Abstract: A method for inducing sensory receptor regeneration includes a step of identifying a subject in need of regeneration of inner ear sensory epithelia. Yap/Tead signaling in the subject is then activated. Typically, Yap/Tead signaling is activated by introducing an expression vector into the subject such that the expression vector contacts inner ear sensory epithelia in a sufficient amount to induce regeneration thereof. Characteristically, the expression vector encodes a constitutively active YAP gene.
    Type: Application
    Filed: April 15, 2021
    Publication date: October 21, 2021
    Inventors: Ksenia GNEDEVA, Neil I. SEGIL, Xizi WANG