Patents by Inventor Kshama Kumari

Kshama Kumari has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hyaluronan synthase genes and expression thereof in hosts
    Patent number: 8735102
    Abstract: The present invention relates to a recombinant Bacillus host cell containing a recombinant vector including a nucleic acid segment having a coding region segment encoding enzymatically active hyaluronan synthase (HAS). The recombinant Bacillus host cell is utilized in a method for producing hyaluronic acid (HA).
    Type: Grant
    Filed: July 5, 2011
    Date of Patent: May 27, 2014
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Paul L. DeAngelis, Paul H. Weigel, Kshama Kumari
  • HYALURONAN SYNTHASE GENES AND EXPRESSION THEREOF IN BACILLUS HOSTS
    Publication number: 20110287487
    Abstract: The present invention relates to a recombinant Bacillus host cell containing a recombinant vector including a nucleic acid segment having a coding region segment encoding enzymatically active hyaluronan synthase (HAS). The recombinant Bacillus host cell is utilized in a method for producing hyaluronic acid (HA).
    Type: Application
    Filed: July 5, 2011
    Publication date: November 24, 2011
    Inventors: Paul L. DeAngelis, Paul H. Weigel, Kshama Kumari
  • Hyaluronan synthase genes and expression thereof in bacillus hosts
    Publication number: 20090155852
    Abstract: The present invention relates to a recombinant Bacillus host cell containing a recombinant vector including a nucleic acid segment having a coding region segment encoding enzymatically active hyaluronan synthase (HAS). The recombinant Bacillus host cell is utilized in a method for producing hyaluronic acid (HA).
    Type: Application
    Filed: August 11, 2008
    Publication date: June 18, 2009
    Inventors: Paul L. DeAngelis, Paul H. Weigel, Kshama Kumari
  • Hyaluronan synthase gene and uses thereof
    Patent number: 7504246
    Abstract: The present invention relates to a recombinantly produced, enzymatically active hyaluronan synthase, wherein the recombinantly produced, enzymatically active hyaluronan synthase is a single protein that is a dual-action catalyst that utilizes UDP-GlcA and UDP-GlcNAc to synthesize HA. The recombinantly produced, enzymatically active hyaluronan synthase may be produced from a hyaluronan synthase gene isolated from a microbial source, such as a streptococcal source.
    Type: Grant
    Filed: November 14, 2006
    Date of Patent: March 17, 2009
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Paul H. Weigel, Kshama Kumari, Paul DeAngelis
  • Hyaluronan synthase genes and expression thereof in Bacillus hosts
    Publication number: 20070166793
    Abstract: The present invention relates to a recombinant Bacillus host cell containing a recombinant vector including a nucleic acid segment having a coding region segment encoding enzymatically active hyaluronan synthase (HAS). The recombinant Bacillus host cell is utilized in a method for producing hyaluronic acid (HA).
    Type: Application
    Filed: March 15, 2007
    Publication date: July 19, 2007
    Inventors: Paul DeAngelis, Paul Weigel, Kshama Kumari
  • Hyaluronan synthase genes and expression thereof in hosts
    Patent number: 7229796
    Abstract: The present invention relates to a recombinant Bacillus host cell containing a recombinant vector including a nucleic acid segment having a coding region segment encoding enzymatically active hyaluronan synthase (HAS). The recombinant Bacillus host cell is utilized in a method for producing hyaluronic acid (HA).
    Type: Grant
    Filed: June 26, 2006
    Date of Patent: June 12, 2007
    Inventors: Paul L. DeAngelis, Paul H. Weigel, Kshama Kumari
  • Hyaluronan synthase gene and uses thereof
    Publication number: 20070087416
    Abstract: The present invention relates to a recombinantly produced, enzymatically active hyaluronan synthase, wherein the recombinantly produced, enzymatically active hyaluronan synthase is a single protein that is a dual-action catalyst that utilizes UDP-GlcA and UDP-GlcNAc to synthesize HA. The recombinantly produced, enzymatically active hyaluronan synthase may be produced from a hyaluronan synthase gene isolated from a microbial source, such as a streptococcal source.
    Type: Application
    Filed: November 14, 2006
    Publication date: April 19, 2007
    Inventors: Paul Weigel, Kshama Kumari, Paul DeAngelis
  • Hyaluronan synthase gene and uses thereof
    Patent number: 7166450
    Abstract: The present invention relates to a method of producing hyaluronic acid that includes introducing a purified nucleic acid segment having a coding region encoding enzymatically active hyaluronan synthase into a Bacillus strain, and culturing the Bacillus strain under conditions appropriate for the production of hyaluronic acid.
    Type: Grant
    Filed: June 5, 2006
    Date of Patent: January 23, 2007
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Paul H. Weigel, Kshama Kumari, Paul DeAngelis
  • Hyaluronan synthase gene and uses thereof
    Patent number: 7153677
    Abstract: The present invention relates to a recombinantly produced, enzymatically active hyaluronan synthase, wherein the recombinantly produced, enzymatically active hyaluronan synthase is a single protein that is a dual-action catalyst that utilizes UDP-GlcA and UDP-GlcNAc to synthesize HA. The recombinantly produced, enzymatically active hyaluronan synthase may be produced from a hyaluronan synthase gene isolated from a microbial source, such as a streptococcal source.
    Type: Grant
    Filed: June 5, 2006
    Date of Patent: December 26, 2006
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Paul H. Weigel, Kshama Kumari, Paul DeAngelis
  • Hyaluronan synthase gene and uses thereof
    Patent number: 7141409
    Abstract: The present invention relates to a recombinant host cell that includes an expression construct having a hyaluronan synthase gene that encodes an enzymatically active hyaluronan synthase (HAS), and to the use of these recombinant cells that produce hyaluronan synthase and its hyaluronic acid product.
    Type: Grant
    Filed: June 5, 2006
    Date of Patent: November 28, 2006
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Paul H. Weigel, Kshama Kumari, Paul DeAngelis
  • Hyaluronan synthase genes and expression thereof in Bacillus hosts
    Publication number: 20060263858
    Abstract: The present invention relates to a recombinant Bacillus host cell containing a recombinant vector including a nucleic acid segment having a coding region segment encoding enzymatically active hyaluronan synthase (HAS). The recombinant Bacillus host cell is utilized in a method for producing hyaluronic acid (HA).
    Type: Application
    Filed: June 26, 2006
    Publication date: November 23, 2006
    Inventors: Paul DeAngelis, Paul Weigel, Kshama Kumari
  • Hyaluronan synthase gene and uses thereof
    Patent number: 7115405
    Abstract: The present invention relates to a nucleic acid segment having a coding region segment encoding enzymatically active hyaluronate synthase (HAS), and to the use of this nucleic acid segment in the preparation of recombinant cells which produce hyaluronate synthase and its hyaluronic acid product. Hyaluronate is also known as hyaluronic acid or hyaluronan.
    Type: Grant
    Filed: September 16, 2005
    Date of Patent: October 3, 2006
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Paul H. Weigel, Kshama Kumari, Paul DeAngelis
  • HYALURONAN SYNTHASE GENE AND USES THEREOF
    Publication number: 20060216794
    Abstract: The present invention relates to a recombinant host cell that includes an expression construct having a hyaluronan synthase gene that encodes an enzymatically active hyaluronan synthase (HAS), and to the use of these recombinant cells that produce hyaluronan synthase and its hyaluronic acid product.
    Type: Application
    Filed: June 5, 2006
    Publication date: September 28, 2006
    Inventors: Paul Weigel, Kshama Kumari, Paul DeAngelis
  • HYALURONAN SYNTHASE GENE AND USES THEREOF
    Publication number: 20060216808
    Abstract: The present invention relates to a recombinantly produced, enzymatically active hyaluronan synthase, wherein the recombinantly produced, enzymatically active hyaluronan synthase is a single protein that is a dual-action catalyst that utilizes UDP-GlcA and UDP-GlcNAc to synthesize HA. The recombinantly produced, enzymatically active hyaluronan synthase may be produced from a hyaluronan synthase gene isolated from a microbial source, such as a streptococcal source.
    Type: Application
    Filed: June 5, 2006
    Publication date: September 28, 2006
    Inventors: Paul Weigel, Kshama Kumari, Paul DeAngelis
  • HYALURONAN SYNTHASE GENE AND USES THEREOF
    Publication number: 20060216793
    Abstract: The present invention relates to a method of producing hyaluronic acid that includes introducing a purified nucleic acid segment having a coding region encoding enzymatically active hyaluronan synthase into a Bacillus strain, and culturing the Bacillus strain under conditions appropriate for the production of hyaluronic acid.
    Type: Application
    Filed: June 5, 2006
    Publication date: September 28, 2006
    Inventors: Paul Weigel, Kshama Kumari, Paul DeAngelis
  • Hyaluronan synthases and methods of making and using same
    Publication number: 20060211104
    Abstract: A functionally active hyaluronan synthase having at least one modified amino acid residue therein as compared to a corresponding functionally active native hyaluronan synthase such that the functionally active hyaluronan synthase has an altered enzymatic activity as compared to the corresponding functionally active native hyaluronan synthase is disclosed. Methods of producing hyaluronic acid utilizing a recombinant host cell having an expression construct encoding the functionally active hyaluronan synthase with altered enzymatic activity are also disclosed.
    Type: Application
    Filed: May 31, 2006
    Publication date: September 21, 2006
    Inventors: Paul Weigel, Kshama Kumari
  • Hyaluronan synthase gene and uses thereof
    Patent number: 7109011
    Abstract: The present invention relates to a nucleic acid segment having a coding region segment encoding enzymatically active Streptococcus equisimilis hyaluronate synthase (seHAS), and to the use of this nucleic acid segment in the preparation of recombinant cells which produce hyaluronate synthase and its hyaluronic acid product. Hyaluronate is also known as hyaluronic acid or hyaluronan.
    Type: Grant
    Filed: December 11, 2001
    Date of Patent: September 19, 2006
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Paul H. Weigel, Kshama Kumari, Paul DeAngelis
  • Hyaluronan synthases and methods of making and using same
    Patent number: 7094581
    Abstract: A functionally active hyaluronan synthase having at least one modified amino acid residue therein as compared to a corresponding functionally active native hyaluronan synthase such that the functionally active hyaluronan synthase has an altered enzymatic activity as compared to the corresponding functionally active native hyaluronan synthase is disclosed. Methods of producing hyaluronic acid utilizing a recombinant host cell having an expression construct encoding the functionally active hyaluronan synthase with altered enzymatic activity are also disclosed.
    Type: Grant
    Filed: December 3, 2002
    Date of Patent: August 22, 2006
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Paul H. Weigel, Kshama Kumari
  • Hyaluronan synthase genes and expression thereof in hosts
    Patent number: 7091008
    Abstract: The present invention relates to a recombinant Bacillus host cell containing a recombinant vector including a nucleic acid segment having a coding region segment encoding enzymatically active hyaluronan synthase (HAS). The recombinant Bacillus host cell is utilized in a method for producing hyaluronic acid (HA).
    Type: Grant
    Filed: November 5, 2004
    Date of Patent: August 15, 2006
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Paul L. DeAngelis, Paul H. Weigel, Kshama Kumari
  • Hyaluronan synthase gene and uses thereof
    Patent number: 7087413
    Abstract: The present invention relates to a nucleic acid segment having a coding region segment encoding enzymatically active Streptococcus equisimilis hyaluronate synthase (seHAS), and to the use of this nucleic acid segment in the preparation of recombinant cells which produce hyaluronate synthase and its hyaluronic acid product. Hyaluronate is also known as hyaluronic acid or hyaluronan.
    Type: Grant
    Filed: September 14, 2005
    Date of Patent: August 8, 2006
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Paul H. Weigel, Kshama Kumari, Paul DeAngelis