Patents by Inventor Kshitija Garde
Kshitija Garde has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11969329Abstract: A “dry” packaging in which a prosthetic heart valve is packaged within a container with hydrogel that can be provided in many forms. Certain embodiments include hydrogel that is preloaded with glycerol or the like. The hydrogel regulates the humidity within the container through a diffusion-driven mechanism if a gradient of humidity between the inside and the outside of the hydrogel exists. Humidity regulation is important to prevent the tissue of the valve structure from drying out. When the partially-hydrated hydrogel is present within container, which is saturated with air of a predefined humidity, the water molecules from the air will be absorbed by the hydrogel if the air humidity is high (i.e. when the thermodynamics favor hydrogel hydration) or vice versa. Various embodiments are configured to also house at least a portion of a delivery device for delivering the prosthetic heart valve.Type: GrantFiled: May 3, 2022Date of Patent: April 30, 2024Assignee: MEDTRONIC VASCULAR, INC.Inventors: Raymond Ryan, David Clarke, Kshitija Garde, Ya Guo, Benjamin Wong, Yogesh Darekar, Luke Lehmann, Wei Wang, Laura McKinley, Paul Devereux, Joshua Dudney, Tracey Tien, Karl Olney
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Patent number: 11957560Abstract: An assembly includes a medical device having a stent and a prosthetic valve connected to the stent. The prosthetic valve includes valve leaflets. The assembly further includes a buffer piece having a leaflet cover and a removable attaching structure. The leaflet cover protects the valve leaflets and the removable attaching structure removably attaches the buffer piece to the medical device. The buffer piece prevents contact, imprinting, abrasion, and/or damage to the valve leaflets.Type: GrantFiled: December 8, 2021Date of Patent: April 16, 2024Assignee: Medtronic Vacular, Inc.Inventors: Thuy Linh Dinh, Alkindi Kibria, Victoria Ung, Veronica Woen, Priyanka Ganesh, Kshitija Garde
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Publication number: 20230301781Abstract: A transcatheter valve prosthesis includes an expandable tubular stent, a prosthetic valve within the stent, and an anti-paravalvular leakage component coupled to and encircling the tubular stent. The anti-paravalvular leakage component includes a radially-compressible annular scaffold, which is a sinusoidal patterned ring of self-expanding material, and an impermeable membrane extending over the annular scaffold. The anti-paravalvular leakage component has an expanded configuration in which at least segments of the annular scaffold curve radially away from the tubular stent. Alternatively, the anti-paravalvular leakage component includes a plurality of self-expanding segments and an annular sealing element coupled to inner surfaces of the segments. The anti-paravalvular leakage component has an expanded configuration in which the segments curve radially away from the tubular stent and the annular sealing element is positioned between an outer surface of the tubular stent and inner surfaces of the segments.Type: ApplicationFiled: May 18, 2023Publication date: September 28, 2023Inventors: Kshitija GARDE, Joel RACCHINI, Paul ROTHSTEIN, Jeffrey SANDSTROM
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Patent number: 11690713Abstract: A transcatheter valve prosthesis includes an expandable tubular stent, a prosthetic valve within the stent, and an anti-paravalvular leakage component coupled to and encircling the tubular stent. The anti-paravalvular leakage component includes a radially-compressible annular scaffold, which is a sinusoidal patterned ring of self-expanding material, and an impermeable membrane extending over the annular scaffold. The anti-paravalvular leakage component has an expanded configuration in which at least segments of the annular scaffold curve radially away from the tubular stent. Alternatively, the anti-paravalvular leakage component includes a plurality of self-expanding segments and an annular sealing element coupled to inner surfaces of the segments. The anti-paravalvular leakage component has an expanded configuration in which the segments curve radially away from the tubular stent and the annular sealing element is positioned between an outer surface of the tubular stent and inner surfaces of the segments.Type: GrantFiled: June 3, 2020Date of Patent: July 4, 2023Assignee: Medtronic CV Luxembourg S.A.R.L.Inventors: Kshitija Garde, Joel Racchini, Paul Rothstein, Jeffrey Sandstrom
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Publication number: 20230172701Abstract: An assembly includes a medical device having a stent and a prosthetic valve connected to the stent. The prosthetic valve includes valve leaflets. The assembly further includes a buffer piece having a leaflet cover and a removable attaching structure. The leaflet cover protects the valve leaflets and the removable attaching structure removably attaches the buffer piece to the medical device. The buffer piece prevents contact, imprinting, abrasion, and/or damage to the valve leaflets.Type: ApplicationFiled: December 8, 2021Publication date: June 8, 2023Inventors: Alkindi Kibria, Thuy Linh Dinh, Victoria Ung, Veronica Woen, Priyanka Ganesh, Kshitija Garde
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Publication number: 20220304805Abstract: A method of preventing paravalvular leakage includes concurrent delivery of a heart valve prosthesis and an annular sealing component. During delivery, the sealing component is moved from a first position to a second position of the heart valve prosthesis which is longitudinally spaced apart from the first position of the heart valve prosthesis. The sealing component is secured around the heart valve prosthesis at the second position by a contoured outer surface of the heart valve prosthesis. The sealing component may be a flexible ring or may be a cylindrical flexible sleeve having a plurality of ribs longitudinally extending over the cylindrical sleeve. The ribs operate to deploy the sealing component such that at least a portion of the cylindrical sleeve buckles outwardly away from the outer surface of the heart valve prosthesis.Type: ApplicationFiled: June 16, 2022Publication date: September 29, 2022Inventors: Cynthia Clague, Scott Mosher, Marian Creaven, Declan Costello, Gavin Kenny, Michael Krivoruchko, Adam Shipley, Mark Torianni, Kshitija Garde, Eric Richardson
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Publication number: 20220257360Abstract: A “dry” packaging in which a prosthetic heart valve is packaged within a container with hydrogel that can be provided in many forms. Certain embodiments include hydrogel that is preloaded with glycerol or the like. The hydrogel regulates the humidity within the container through a diffusion-driven mechanism if a gradient of humidity between the inside and the outside of the hydrogel exists. Humidity regulation is important to prevent the tissue of the valve structure from drying out. When the partially-hydrated hydrogel is present within container, which is saturated with air of a predefined humidity, the water molecules from the air will be absorbed by the hydrogel if the air humidity is high (i.e. when the thermodynamics favor hydrogel hydration) or vice versa. Various embodiments are configured to also house at least a portion of a delivery device for delivering the prosthetic heart valve.Type: ApplicationFiled: May 3, 2022Publication date: August 18, 2022Applicant: Medtronic Vascular, Inc.Inventors: Raymond Ryan, David Clarke, Kshitija Garde, Ya Guo, Benjamin Wong, Yogesh Darekar, Luke Lehmann, Wei Wang, Laura McKinley, Paul Devereux, Joshua Dudney, Tracey Tien, Karl Olney
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Patent number: 11389293Abstract: A method of preventing paravalvular leakage includes concurrent delivery of a heart valve prosthesis and an annular sealing component. During delivery, the sealing component is moved from a first position to a second position of the heart valve prosthesis which is longitudinally spaced apart from the first position of the heart valve prosthesis. The sealing component is secured around the heart valve prosthesis at the second position by a contoured outer surface of the heart valve prosthesis. The sealing component may be a flexible ring or may be a cylindrical flexible sleeve having a plurality of ribs longitudinally extending over the cylindrical sleeve. The ribs operate to deploy the sealing component such that at least a portion of the cylindrical sleeve buckles outwardly away from the outer surface of the heart valve prosthesis.Type: GrantFiled: October 10, 2019Date of Patent: July 19, 2022Assignee: MEDTRONIC, INC.Inventors: Mark Torrianni, Kshitija Garde, Eric Richardson
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Patent number: 11344399Abstract: A “dry” packaging in which a prosthetic heart valve is packaged within a container with hydrogel that can be provided in many forms. Certain embodiments include hydrogel that is preloaded with glycerol or the like. The hydrogel regulates the humidity within the container through a diffusion-driven mechanism if a gradient of humidity between the inside and the outside of the hydrogel exists. Humidity regulation is important to prevent the tissue of the valve structure from drying out. When the partially-hydrated hydrogel is present within container, which is saturated with air of a predefined humidity, the water molecules from the air will be absorbed by the hydrogel if the air humidity is high (i.e. when the thermodynamics favor hydrogel hydration) or vice versa. Various embodiments are configured to also house at least a portion of a delivery device for delivering the prosthetic heart valve.Type: GrantFiled: December 8, 2020Date of Patent: May 31, 2022Assignee: Medtronic Vascular, Inc.Inventors: Raymond Ryan, David Clarke, Kshitija Garde, Ya Guo, Benjamin Wong, Yogesh Darekar, Luke Lehmann, Wei Wang, Laura McKinley, Paul Devereux, Joshua Dudney, Tracey Tien, Karl Olney
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Patent number: 11278397Abstract: Prosthetic heart valve devices and associated methods for percutaneous or transcatheter heart valve replacement are disclosed herein. A heart valve prosthesis configured in accordance herewith includes a frame having a valve support and a plurality of support arms extending therefrom. The plurality of support arms may include a main support arm configured to extend from the valve support for capturing at least a portion of a valve leaflet of a native heart valve therebetween when the valve prosthesis is in an expanded configuration and deployed within the native heart valve. In addition, the plurality of support arms may include multiple supplemental support arms disposed about the circumference of the valve support that when deployed in the expanded configuration are configured to at least partially engage subannular tissue at the native heart valve.Type: GrantFiled: May 6, 2019Date of Patent: March 22, 2022Assignee: MEDTRONIC, INC.Inventors: Jason Quill, Padraig Savage, Joshua Dwork, Kshitija Garde, Sarah Ahlberg, Igor Kovalsky
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Publication number: 20220054266Abstract: Heart valve prosthesis are disclosed that include a frame or support structure having an inflow portion, a valve-retaining tubular or central portion and a pair of support arms. The inflow portion radially extends from a first end of the valve-retaining tubular portion and the pair of support arms are circumferentially spaced apart and radially extend from an opposing second end of the valve-retaining tubular portion.Type: ApplicationFiled: September 2, 2021Publication date: February 24, 2022Inventors: Igor KOVALSKY, Cathleen BERGIN, Marian CREAVEN, Joshua DWORK, Kshitija GARDE, Daniel GLOZMAN, Ilia HARITON, Pham LO, Jason QUILL, Jeffrey SANDSTROM, Padraig SAVAGE, Michael SCHENDEL, Elizabeth SCHOTZKO, Yossi TUVAL, Nadav YELLIN
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Publication number: 20210275298Abstract: A transcatheter valve prosthesis includes a stent and a prosthetic valve. The stent includes an inflow portion, an outflow portion, and a transition portion extending between the inflow portion and the outflow portion. The transition portion includes a plurality of axial frame members, and three of the plurality of the axial frame members are commissure posts. At least two of the plurality of the axial frame members are commissure posts having a first end connected to a crown of the inflow portion and an unattached second end disposed within the outflow portion such that a pair of struts of the outflow portion intersect each commissure post at a mid-portion thereof. The prosthetic valve is configured to substantially block blood flow in one direction to regulate blood flow through a central lumen of the stent.Type: ApplicationFiled: February 26, 2021Publication date: September 9, 2021Inventors: Justin PETERSON, Stuart KARI, Shahnaz JAVANI, Genevieve FARRAR, Syed ASKARI, Alkindi KIBRIA, Karl OLNEY, Kshitija GARDE, Justin GOSHGARIAN, Tracey TIEN, Yas NEUBERGER, Matthew BALDWIN, Finn RINNE, Michael KRIVORUCHKO, Ethan KORNGOLD, Mark CASLEY
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Publication number: 20210205075Abstract: A transcatheter valve prosthesis includes an expandable tubular stent, a prosthetic valve within the stent, and an anti-paravalvular leakage component coupled to and encircling the tubular stent. The anti-paravalvular leakage component includes a radially-compressible annular scaffold, which is a sinusoidal patterned ring of self-expanding material, and an impermeable membrane extending over the annular scaffold. The anti-paravalvular leakage component has an expanded configuration in which at least segments of the annular scaffold curve radially away from the tubular stent. Alternatively, the anti-paravalvular leakage component includes a plurality of self-expanding segments and an annular sealing element coupled to inner surfaces of the segments. The anti-paravalvular leakage component has an expanded configuration in which the segments curve radially away from the tubular stent and the annular sealing element is positioned between an outer surface of the tubular stent and inner surfaces of the segments.Type: ApplicationFiled: March 24, 2021Publication date: July 8, 2021Inventors: Carol EBERHARDT, Gopikrishnan SOUNDARARAJAN, Kenny DANG, Hussain RANGWALA, Mark TORRIANNI, Eric RICHARDSON, Kshitija GARDE
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Publication number: 20210113320Abstract: A “dry” packaging in which a prosthetic heart valve is packaged within a container with hydrogel that can be provided in many forms. Certain embodiments include hydrogel that is preloaded with glycerol or the like. The hydrogel regulates the humidity within the container through a diffusion-driven mechanism if a gradient of humidity between the inside and the outside of the hydrogel exists. Humidity regulation is important to prevent the tissue of the valve structure from drying out. When the partially-hydrated hydrogel is present within container, which is saturated with air of a predefined humidity, the water molecules from the air will be absorbed by the hydrogel if the air humidity is high (i.e. when the thermodynamics favor hydrogel hydration) or vice versa. Various embodiments are configured to also house at least a portion of a delivery device for delivering the prosthetic heart valve.Type: ApplicationFiled: December 8, 2020Publication date: April 22, 2021Applicant: Medtronic Vascular, Inc.Inventors: Raymond Ryan, David Clarke, Kshitija Garde, Ya Guo, Benjamin Wong, Yogesh Darekar, Luke Lehmann, Wei Wang, Laura McKinley, Paul Devereux, Joshua Dudney, Tracey Tien, Karl Olney
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Patent number: 10973630Abstract: A transcatheter valve prosthesis includes an expandable tubular stent, a prosthetic valve within the stent, and an anti-paravalvular leakage component coupled to and encircling the tubular stent. The anti-paravalvular leakage component includes a radially-compressible annular scaffold, which is a sinusoidal patterned ring of self-expanding material, and an impermeable membrane extending over the annular scaffold. The anti-paravalvular leakage component has an expanded configuration in which at least segments of the annular scaffold curve radially away from the tubular stent. Alternatively, the anti-paravalvular leakage component includes a plurality of self-expanding segments and an annular sealing element coupled to inner surfaces of the segments. The anti-paravalvular leakage component has an expanded configuration in which the segments curve radially away from the tubular stent and the annular sealing element is positioned between an outer surface of the tubular stent and inner surfaces of the segments.Type: GrantFiled: September 16, 2019Date of Patent: April 13, 2021Assignee: MEDTRONIC CV LUXEMBOURG S.A.R.L.Inventors: Mark Torrianni, Eric Richardson, Kshitija Garde
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Publication number: 20210068950Abstract: Prosthetic heart valve devices and associated methods for percutaneous or transcatheter heart valve replacement are disclosed herein. A heart valve prosthesis configured in accordance herewith includes a frame having a valve support and a plurality of support arms extending therefrom. The plurality of support arms may include a main support arm configured to extend from the valve support for capturing at least a portion of a valve leaflet of a native heart valve therebetween when the valve prosthesis is in an expanded configuration and deployed within the native heart valve. In addition, the plurality of support arms may include multiple supplemental support arms disposed about the circumference of the valve support that when deployed in the expanded configuration are configured to at least partially engage subannular tissue at the native heart valve.Type: ApplicationFiled: November 11, 2020Publication date: March 11, 2021Inventors: Jason Quill, Padraig Savage, Joshua Dwork, Kshitija Garde, Sarah Ahlberg, Igor Kovalsky
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Patent number: 10888408Abstract: A “dry” packaging in which a prosthetic heart valve is packaged within a container with hydrogel that can be provided in many forms. Certain embodiments include hydrogel that is preloaded with glycerol or the like. The hydrogel regulates the humidity within the container through a diffusion-driven mechanism if a gradient of humidity between the inside and the outside of the hydrogel exists. Humidity regulation is important to prevent the tissue of the valve structure from drying out. When the partially-hydrated hydrogel is present within container, which is saturated with air of a predefined humidity, the water molecules from the air will be absorbed by the hydrogel if the air humidity is high (i.e. when the thermodynamics favor hydrogel hydration) or vice versa. Various embodiments are configured to also house at least a portion of a delivery device for delivering the prosthetic heart valve.Type: GrantFiled: May 2, 2018Date of Patent: January 12, 2021Assignee: Medtronic Vascular, Inc.Inventors: Raymond Ryan, David Clarke, Kshitija Garde, Ya Guo, Benjamin Wong, Yogesh Darekar, Luke Lehmann, Wei Wang, Laura McKinley, Paul Devereux, Joshua Dudney, Tracey Tien, Karl Olney
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Publication number: 20200289262Abstract: A transcatheter valve prosthesis includes an expandable tubular stent, a prosthetic valve within the stent, and an anti-paravalvular leakage component coupled to and encircling the tubular stent. The anti-paravalvular leakage component includes a radially-compressible annular scaffold, which is a sinusoidal patterned ring of self-expanding material, and an impermeable membrane extending over the annular scaffold. The anti-paravalvular leakage component has an expanded configuration in which at least segments of the annular scaffold curve radially away from the tubular stent. Alternatively, the anti-paravalvular leakage component includes a plurality of self-expanding segments and an annular sealing element coupled to inner surfaces of the segments. The anti-paravalvular leakage component has an expanded configuration in which the segments curve radially away from the tubular stent and the annular sealing element is positioned between an outer surface of the tubular stent and inner surfaces of the segments.Type: ApplicationFiled: June 3, 2020Publication date: September 17, 2020Inventors: Kshitija GARDE, Joel RACCHINI, Paul ROTHSTEIN, Jeffrey SANDSTROM
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Patent number: 10702379Abstract: A transcatheter valve prosthesis includes an expandable tubular stent, a prosthetic valve within the stent, and an anti-paravalvular leakage component coupled to and encircling the tubular stent. The anti-paravalvular leakage component includes a radially-compressible annular scaffold, which is a sinusoidal patterned ring of self-expanding material, and an impermeable membrane extending over the annular scaffold. The anti-paravalvular leakage component has an expanded configuration in which at least segments of the annular scaffold curve radially away from the tubular stent. Alternatively, the anti-paravalvular leakage component includes a plurality of self-expanding segments and an annular sealing element coupled to inner surfaces of the segments. The anti-paravalvular leakage component has an expanded configuration in which the segments curve radially away from the tubular stent and the annular sealing element is positioned between an outer surface of the tubular stent and inner surfaces of the segments.Type: GrantFiled: April 24, 2017Date of Patent: July 7, 2020Assignee: Medtronic CV Luxembourg S.a.r.l.Inventors: Kshitija Garde, Joel Racchini, Paul Rothstein, Jeffrey Sandstrom
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Publication number: 20200038182Abstract: A method of preventing paravalvular leakage includes concurrent delivery of a heart valve prosthesis and an annular sealing component. During delivery, the sealing component is moved from a first position to a second position of the heart valve prosthesis which is longitudinally spaced apart from the first position of the heart valve prosthesis. The sealing component is secured around the heart valve prosthesis at the second position by a contoured outer surface of the heart valve prosthesis. The sealing component may be a flexible ring or may be a cylindrical flexible sleeve having a plurality of ribs longitudinally extending over the cylindrical sleeve. The ribs operate to deploy the sealing component such that at least a portion of the cylindrical sleeve buckles outwardly away from the outer surface of the heart valve prosthesis.Type: ApplicationFiled: October 10, 2019Publication date: February 6, 2020Inventors: Mark TORRIANNI, Kshitija GARDE, Eric RICHARDSON