Patents by Inventor Kuaile Lin

Kuaile Lin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for preparing a sitagliptin intermediate
    Patent number: 9745309
    Abstract: The present invention provides a method for preparing an intermediate compound of sitagliptin represented by formula I. The preparation method comprises: dissolving a compound represented by formula II into an organic solvent; and under the catalysis of fatty acid and effect of chlorosilane, performing a reduction reaction of carbon-carbon double bonds, so as to obtain the intermediate compound of sitagliptin represented by formula I, R being methyl or formoxyl. The preparation method of the present invention avoids precious metal as a catalyst, and accordingly, the cost is low, the post-treatment is simple, the product has a high yield, chemical purity and optical purity, and de % is greater than 99.6%, and the preparation method can be used in synthesis of sitagliptin and is suitable for industrial production.
    Type: Grant
    Filed: September 9, 2014
    Date of Patent: August 29, 2017
    Assignees: Shanghai Institute of Pharmaceutical Industry, Zhejiang Medicine Co., Ltd.
    Inventors: Kuaile Lin, Zhengyan Cai, Jing Pan, Weicheng Zhou, Guofeng Wu, Lirong Yue, Dadong Shen
  • METHOD FOR PREPARING INTERMEDIATE COMPOUND OF SITAGLIPTIN
    Publication number: 20160229859
    Abstract: The present invention provides a method for preparing an intermediate compound of sitagliptin represented by formula I. The preparation method comprises: dissolving a compound represented by formula II into an organic solvent; and under the catalysis of fatty acid and effect of chlorosilane, performing a reduction reaction of carbon-carbon double bonds, so as to obtain the intermediate compound of sitagliptin represented by formula I, R being methyl or formoxyl. The preparation method of the present invention avoids precious metal as a catalyst, and accordingly, the cost is low, the post-treatment is simple, the product has a high yield, chemical purity and optical purity, and de % is greater than 99.6%, and the preparation method can be used in synthesis of sitagliptin and is suitable for industrial production.
    Type: Application
    Filed: September 9, 2014
    Publication date: August 11, 2016
    Inventors: Kuaile Lin, Zhengyan Cai, Jing Pan, Weicheng Zhou, Guofeng Wu, Lirong Yue, Dadong Shen