Abstract: The present invention provides a fusion protein, comprising a chemokine polypeptide, which is a chemokine or a receptor binding domain thereof; and a cytokine polypeptide connected to said chemokine polypeptide, which is an interleukin, a TNF-superfamily cytokine or a receptor-binding domain thereof; wherein the chemokine polypeptide and the cytokine polypeptide have a common target cell, and the fusion protein has an improved chemokine activity as compared to the chemokine polypeptide, and an improved cytokine activity as compared to the cytokine polypeptide.

Abstract: The present invention provides a fusion protein, comprising a chemokine polypeptide, which is a chemokine or a receptor binding domain thereof; and a cytokine polypeptide connected to said chemokine polypeptide, which is an interleukin, a TNF-superfamily cytokine or a receptor-binding domain thereof; wherein the chemokine polypeptide and the cytokine polypeptide have a common target cell, and the fusion protein has an improved chemokine activity as compared to the chemokine polypeptide, and an improved cytokine activity as compared to the cytokine polypeptide.

Abstract: The present invention provides a fusion protein, comprising a chemokine polypeptide, which is a chemokine or a receptor binding domain thereof; and a cytokine polypeptide connected to said chemokine polypeptide, which is an interleukin, a TNF-superfamily cytokine or a receptor-binding domain thereof; wherein the chemokine polypeptide and the cytokine polypeptide have a common target cell, and the fusion protein has an improved chemokine activity as compared to the chemokine polypeptide, and an improved cytokine activity as compared to the cytokine polypeptide.

Abstract: The present invention provides a fusion protein, comprising a chemokine polypeptide, which is a chemokine or a receptor binding domain thereof; and a cytokine polypeptide connected to said chemokine polypeptide, which is an interleukin, a TNF-superfamily cytokine or a receptor-binding domain thereof; wherein the chemokine polypeptide and the cytokine polypeptide have a common target cell, and the fusion protein has an improved chemokine activity as compared to the chemokine polypeptide, and an improved cytokine activity as compared to the cytokine polypeptide.

Abstract: A Chinese medicine prescription capable of treating lung adenocarcinoma is composed of Polygala tenuifolia Willd, atractylodes macrocephala, angelica sinensis, poria pararadicis, astragalus membranaceus, ziziphus jujaba Mill.var.spinosa, codonopsis pilosula, costustoot, radix glycyrrhizae preparata and fresh ginger, and a pharmaceutical residue is filtered and obtained after a water quenching procedure of the aforementioned herbs to provide a water-quenched medicine soup, and a pharmaceutical residue is filtered and obtained after processing the water-quenched pharmaceutical residue by a liquor quenching procedure to obtain a liquor-quenched medicine soup; and the water-quenched medicine soup and the liquor-quenched medicine soup are mixed. The prescription is capable of triggering cell autophagy and reducing cell growth, expansion and metastasis, so as to achieve the effect of lung adenocarcinoma treatment.

Abstract: A Chinese medicine capable of triggering lung adenocarcinoma cell autophagy mainly uses a polygala tenuifolia willd herb with a quantity depending on a patient's physical fitness and sickness conditions determined by a doctor, and capable of triggering a lung adenocarcionma cell autophagy (cracking) to achieve a treatment effect. Regardless of being taken as a powder or an extract, the medicine is capable of triggering the adenocarcionma cell autophagy (cracking) effect to achieve the treatment effect. The polygala tenuifolia willd applies a new protein transport mode as a target enzyme screening to successfully prove the effect of triggering lung adenocarcionma cell autophagy (cracking) for cancer treatment.

Abstract: In a method for quick-search of loci-of-interest in a gene sequence of a target biological virus, a computer executes a phylogenetic algorithm to generate phylogenetic tree information, which is generated based on a selected gene segment of the target biological virus and a corresponding gene segment of each of related biological viruses. A set of to-be-matched biological viruses is determined based on the phylogenetic tree information. A computer matches the gene sequences of the to-be-matched biological viruses in the set so as to find the loci-of-interest in the gene sequence of the target biological virus.