Abstract: Compounds of Formula (I) shown below and a pharmaceutical composition containing one of the compounds: Each of the variables is defined herein. Also disclosed is a method of treating a condition associated with uncontrolled cell growth with a compound of Formula (I).

Abstract: Provided herein are improved processes and methods for preparing osimertinib or a salt thereof, in particular osimertinib mesylate. The improved process removes the necessity of isolating the unstable aniline intermediate of formula (III) and enables the direct coupling to form the amide product of formula (II): The present invention is suitable for a large-scale production, avoiding the isolation of unstable intermediate, thereby providing osimertinib or a mesylate salt thereof in both high yields and high purity.

Abstract: A one-pot process for preparing cedazuridine of formula (I), comprising: subjecting a compound of formula (M3) to deprotection and then epimerization in a reactor in the presence of a catalyst to obtain a reaction mixture comprising cedazuridine, wherein R on the compound of formula (M3) is independently selected from the group consisting of Ac (acetyl), Bz (benzoyl), p-nitrobenzoyl and OtBu (tert-butyloxycarbonyl), and the deprotection and epimerization are conducted in the same reactor without isolating after the deprotection and before the epimerization; and isolating cedazuridine from the reaction mixture.

Abstract: A fluorescent optical system and a fluorescent image inspection system are provided. The fluorescent optical system includes a platform, at least one light source device, and at least one first filter. The platform is configured for placement of a sample to be inspected. The at least one light source device is configured to illuminate the sample to be inspected, so that the sample to be inspected is stimulated to generate a fluorescent light. The at least one first filter is correspondingly arranged in an optical path of the at least one light source device, so that an excitation light passes through the at least one first filter. An incident angle is formed between the excitation light and the platform, and the incident angle is less than 90 degrees.

Abstract: In certain aspects, the invention provides crystalline forms of ivacaftor N-(2,4-di-tert-butyl-phenyl-5-hydroxy-phenyl)-1,4-dihydro-4-oxoquinoline-3-carboxamide. In related aspects, the invention provides a process for preparing any one of crystalline forms S2, S3, S4 and S5 of ivacaftor. The process includes: forming a solution including crude ivacaftor and a solvent; adding an anti-solvent to the solution to form slurry including a precipitate; isolating the precipitate; and drying the precipitate to provide crystalline form S2, S3, S4, or S5 of ivacaftor.

Abstract: Provided herein are improved processes and methods for preparing osimertinib or a salt thereof, in particular osimertinib mesylate. The improved process removes the necessity of isolating the unstable aniline intermediate of formula (III) and enables the direct coupling to form the amide product of formula (II): The present invention is suitable for a large-scale production, avoiding the isolation of unstable intermediate, thereby providing osimertinib or a mesylate salt thereof in both high yields and high purity.

Abstract: In certain aspects, the invention provides crystalline forms of ivacaftor N-(2,4-di-tert-butyl-phenyl-5-hydroxy-phenyl)-1,4-dihydro-4-oxoquinoline-3-carboxamide. In related aspects, the invention provides a process for preparing any one of crystalline forms S2, S3, S4 and S5 of ivacaftor. The process includes: forming a solution including crude ivacaftor and a solvent; adding an anti-solvent to the solution to form slurry including a precipitate; isolating the precipitate; and drying the precipitate to provide crystalline form S2, S3, S4, or S5 of ivacaftor.

Abstract: Compounds of Formula (I) shown below and a pharmaceutical composition containing one of the compounds: Each of the variables is defined herein. Also disclosed is a method of treating a condition associated with uncontrolled cell growth with a compound of Formula (I).

Abstract: A comparator including an amplifier unit, a latch unit, and a switch unit is provided. The amplifier unit receives and gains an input signal pair respectively and then outputs an output signal pair. The latch unit is coupled to the amplifier unit. During a tracking period, the latch unit is not powered, and during a latching period, the latch unit is powered to latch the output signal pair and then output a logical signal pair accordingly. The switch unit is coupled between the amplifier unit and the latch unit. During the tracking period, the switch unit transfers the output signal pair to the latch unit, and during the latch period, the switch unit separates the amplifier unit from the latch unit, and thereby reducing the influences to the comparator caused by the kick back noise and the offset error.

Abstract: A structural analysis method of deep trenches is provided. A substrate having a plurality of deep trenches is provided. A polishing process is performed on the substrate to form an incline in a partial region of the substrate to expose surface structures at different depths of the deep trenches. Then, a structural analysis of the surface structures at different depths of the deep trenches is performed to observe defects.

Abstract: A switched capacitor circuit includes an amplifier, a first switched capacitor network, and a second switched capacitor network. Either the first or second switched capacitor network is switched in a sampling configuration or a gain configuration according to connection states of the switches thereof. The amplifier includes a first transistor and a second transistor coupled to the first switched capacitor network, and a third transistor and a fourth transistor coupled to the second switched capacitor network. A first switch is coupled to a first connection point of the first and second transistors, and a second switch is coupled to a second connection point of the third and fourth transistors.

Abstract: An optical mouse chip with silicon retina structure comprises an image sensor array, an accumulator and a comparing/selecting unit. The image sensor array senses a direction parameter of an image along each axis. The accumulator sums the direction parameters of the image along different axes. The comparing/selecting unit selects a largest one from the sum of direction parameters of the image along different axes to determine a moving direction of the image.

Abstract: An optical mouse chip with silicon retina structure comprises an image sensor array, an accumulator and a comparing/selecting unit. The image sensor array senses a direction parameter of an image along each axis. The accumulator sums the direction parameters of the image along different axes. The comparing/selecting unit selects a largest one from the sum of direction parameters of the image along different axes to determine a moving direction of the image.