Abstract: A removable denture for an oral cavity of a human is disclosed. The removable denture includes a denture body and a supporting base. The supporting base is attached to mucosa on an edentulous alveolus and on palatine bones in the oral cavity. The denture body is joined to the supporting base. The denture body comprises a denture teeth for chewing. A central region of the supporting base is less flexible than a periphery region of the supporting base so as to maintain a high adhesion of the periphery region to the mucosa when the oral cavity is in chewing. The supporting base comprises an on-way venting device capable of improving the negative pressure effect between the supporting base and the mucosa so as to prevent the supporting base from falling off.