Patents by Inventor Kuan Moon Boo
Kuan Moon Boo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240150699Abstract: An electroporation system including one or more of a pipette, a pipette tip, a pipette docking assembly, and a pulse generator. The pipette docking assembly includes a pipette station, a pipette station guard, and a reservoir (e.g., a buffer tube). A method for transfecting a cell with a payload including providing an electroporation system, providing the cell, providing the payload, introducing the cell and the payload into a pipette tip, and electroporating the cell within the pipette tip by operating the electroporation system.Type: ApplicationFiled: September 15, 2023Publication date: May 9, 2024Inventors: Han WEI, Chee Wai CHAN, Wui Khen LIAW, Shan Hua DONG, See Chen GOH, Huei Steven YEO, Harmon Cosme SICAT, JR., Mio Xiu Lu LING, Josh M. MEAD, Mikko MAKINEN, Beng Heng LIM, Kuan Moon BOO, Justina Linkai BONG, Chye Sin NG, Wee Liam LIM, Li Yang LIM, Way Xuang LEE
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Patent number: 11920191Abstract: An instrument for biological analysis includes a base, an excitation source, an optical sensor, an excitation optical system, and an emission optical system. The base is configured to receive a sample holder comprising a plurality of biological samples. The optical sensor is configured to receive emissions from the biological samples in response to the excitation source. The instrument may additionally include a sensor lens enclosed by a lens case and a focusing mechanism including a gear that engages the lens case, the focusing mechanism being accessible outside the enclosure for adjusting a focus. The may instrument further include a sensor aperture dispose along an emission optical path and a blocking structure disposed to cooperate with the sensor aperture such that none of the reflected radiation from an illuminated surface near the sample holder is received by the optical sensor that does not also reflect off another surface of the instrument.Type: GrantFiled: January 18, 2021Date of Patent: March 5, 2024Assignee: Life Technologies CorporationInventors: Mingsong Chen, Kuan Moon Boo, Tiong Han Toh, Mauro Aguanno, Soo Yong Lau, Huei Yeo, Wei Fuh Teo
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Publication number: 20230417676Abstract: A biological analysis system can include an excitation module and an emission module. The excitation module can include a collimator element for receiving excitation light from the excitation light source and transmitting collimated excitation light in a first direction, and a plurality of excitation mirrors arrayed along the excitation light path, each excitation mirror disposed at an acute angle relative to the first direction and configured to reflect collimated excitation light along a second direction. The emission module can be positioned to receive excitation light transmitted along the second direction and can include a sample block comprising a plurality of sample receptacles positioned to receive a beam of collimated excitation light, and a plurality of photodetectors configured to receive emission light transmitted from a respective sample receptacle in a direction transverse to the second direction of the excitation light path.Type: ApplicationFiled: April 27, 2023Publication date: December 28, 2023Inventors: Ming Song CHEN, Chee Woei CHONG, Wuh Ken LOH, WERN YUH FOO, Kuan Moon BOO, Norbert LECLERC, Kristina UHLENDORF, Reiner KOELLNER, Torsten FUCHS, Stefan Breitfelder
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Patent number: 11815460Abstract: A method of analyzing a plurality of biological sample volumes comprises emitting, along an excitation optical path toward a sample holder holding the plurality of biological sample volumes, electromagnetic radiation from a broadband LED, wherein the broadband LED emits the electromagnetic radiation across a range of wavelengths at a total output power of at least 5 watts and at a maximum intensity at a wavelength less than 600 nanometers and at an intensity less than 30 percent of the maximum intensity at a wavelength of 650 or 670 nanometers, and receiving, by a sensor, an electromagnetic emission transmitted from the sample holder along an emission optical path.Type: GrantFiled: May 26, 2022Date of Patent: November 14, 2023Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Kevin Maher, Mingsong Chen, Jacob K. Freudenthal, Kuan Moon Boo, Soo Yong Lau, David Fortescue, Ming Shen, Woon Liang Terence Soh
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Publication number: 20230221343Abstract: A biological analysis system for performing a performing an assay or experiment includes one or more of a carrier, base, or tray. The carrier, base, or tray is/are configured to interchangeably receive (1) a first block and a corresponding first cover placed over the first block or (2) a second block and a corresponding second cover placed over the second block; The system also includes a computer readable memory comprising instructions for detecting when the second cover is placed over the first block and/or for detecting when the first cover is placed over the second block based on lack of electrical continuity along an electrical path comprising one of the blocks and one of the covers.Type: ApplicationFiled: May 8, 2021Publication date: July 13, 2023Applicant: Life Technologies Holdings PTE LimitedInventors: Kuan Moon Boo, Wei Fuh Teo, Zeqi Tan, Ming Tiong Sia, Ching Yee Lam, Shan Hua Dong, Woon Liang Soh, Soo Yong Lau
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Publication number: 20230221280Abstract: A gel electrophoresis system includes a base module and a camera module. The base module includes a cassette slot for receiving a gel electrophoresis cassette, and a light element that functions to illuminate the gel electrophoresis cassette. The camera module is selectively attachable to and detachable from the base module. When attached to the base module, the camera module facilitates imaging of the gel electrophoresis cassette and provides additional imaging capabilities.Type: ApplicationFiled: December 20, 2022Publication date: July 13, 2023Inventors: Beng Heng LIM, Wuh Ken LOH, Hwee Siong KUAH, Jing Han WONG, Jefferson Cruz GANGCUANGCO, Jin Xin ONG, Soo Yong LAU, Yanping XU, Victor SHAPIRO, Zhi Da TEH, Chee Woei CHONG, Kuan Moon BOO
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Patent number: 11680905Abstract: A biological analysis system can include an excitation module and an emission module. The excitation module can include a collimator element for receiving excitation light from the excitation light source and transmitting collimated excitation light in a first direction, and a plurality of excitation mirrors arrayed along the excitation light path, each excitation mirror disposed at an acute angle relative to the first direction and configured to reflect collimated excitation light along a second direction. The emission module can be positioned to receive excitation light transmitted along the second direction and can include a sample block comprising a plurality of sample receptacles positioned to receive a beam of collimated excitation light, and a plurality of photodetectors configured to receive emission light transmitted from a respective sample receptacle in a direction transverse to the second direction of the excitation light path.Type: GrantFiled: January 11, 2022Date of Patent: June 20, 2023Assignees: Life Technologies Holdings PTE LTD, Life Technologies CorporationInventors: Ming Song Chen, Chee Woei Chong, Wuh Ken Loh, Wern Yuh Foo, Kuan Moon Boo, Norbert Leclerc, Kristina Uhlendorf, Reiner Koellner, Torsten Fuchs, Stefan Breitfelder
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Publication number: 20230106558Abstract: An instrument for processing and/or measuring a biological process comprises a sample processing system and an excitation source exhibiting a spectral function of output power or intensity verses wavelength of output power or intensity. The spectral function has a minima wavelength corresponding to a local minima value of the output power or intensity; a first maxima wavelength corresponding to a first local maxima of output power or intensity, the output power or intensity at the first local maxima being greater than the output power or intensity at any wavelength less than the minima wavelength; a second maxima wavelength corresponding to a second local maxima of output power or intensity, the output power or intensity at the second local maxima being greater than the output at any wavelength greater than the minima wavelength; the minima wavelength is between the first maxima wavelength and the second maxima wavelength.Type: ApplicationFiled: October 7, 2022Publication date: April 6, 2023Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Mingsong CHEN, Mauro AGUANNO, Kuan Moon BOO, Woon Liang Terence SOH, Jacob K. FREUDENTHAL, Jeffrey A. MARKS
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Patent number: 11583862Abstract: A thermal block assembly for use in a biological analysis system includes a sample block, a heating and cooling element, a heat sink including a surface, the surface including a plurality of projections for engaging the heating and cooling element to hold the heating and cooling element on the heat sink. A thermal block assembly for use in a biological analysis system includes a heating and cooling element, a sample block including a lower surface configured to be thermally coupled to the heating and cooling element, one or more temperature sensors configured to extend through the one or more slots of the lower surface of the sample block, and one or more thermal pads between the one or more temperature sensors and heating and cooling element.Type: GrantFiled: September 15, 2016Date of Patent: February 21, 2023Assignee: Life Technologies CorporationInventors: Kuan Moon Boo, Wei Fuh Teo, Wuh Ken Loh, Zeqi Tan, Siew Yin Lee
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Publication number: 20230031117Abstract: A system for biological analysis includes a housing, a block assembly within the housing having a sample block and a baseplate, a heated cover and a cover carrier. The sample block receives a sample holder comprising an RFID tag. A first drive mechanism generates relative movement between the sample block and the baseplate along a first axis. A second drive mechanism generates relative movement between the heated cover and the cover carrier along a second axis that is different from the first axis. Based on a first command the first drive mechanism releasably engages the sample block and operates the second drive mechanism to releasably engage the heated cover with the cover carrier. The system also includes first and second RFID antennas that receive RFID data from the sample holder RFID tag that is read by at least one RFID reader.Type: ApplicationFiled: October 14, 2022Publication date: February 2, 2023Applicants: Life Technologies Holdings PTE Limited, Life Technologies CorporationInventors: Kuan Moon Boo, Wei Fuh Teo, Zeqi Tan, Soo Yong Lau, Ming Tiong Sia, Woon Liang Soh, Ching Yee Lam, Shan Hua Dong, Marc Haberstroh, Michael C. Pallas, Hardeep Sangha
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Publication number: 20220412890Abstract: An instrument for processing and/or measuring a biological process comprises a plurality of filter assemblies configured to be interchangeably located along at least one of the optical paths. The plurality of filter components includes a first filter assembly characterized by a first optical power and a first filter having a first filter function, the first filter function characterized by at least one of a first low-pass wavelength or a first high-pass wavelength. The second filter assembly is characterized by a second optical power and a second filter having a second filter function, the second filter function comprising at least one of a second low-pass wavelength that is different than the first low-pass wavelength or a second high-pass wavelength that is different than the first high-pass wavelength.Type: ApplicationFiled: May 26, 2022Publication date: December 29, 2022Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Kevin MAHER, Mingsong CHEN, Jacob K. FREUDENTHAL, Kuan Moon BOO, Soo Yong LAU, David FORTESCUE, Ming SHEN, Woon Liang Terence SOH
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Patent number: 11480584Abstract: A system for biological analysis includes a housing, a block assembly within the housing having a sample block and a baseplate, a heated cover and a cover carrier. The sample block receives a sample holder comprising an RFID tag. A first drive mechanism generates relative movement between the sample block and the baseplate along a first axis. A second drive mechanism generates relative movement between the heated cover and the cover carrier along a second axis that is different from the first axis. Based on a first command the first drive mechanism releasably engages the sample block and operates the second drive mechanism to releasably engage the heated cover with the cover carrier. The system also includes first and second RFID antennas that receive RFID data from the sample holder RFID tag that is read by at least one RFID reader.Type: GrantFiled: January 30, 2020Date of Patent: October 25, 2022Assignees: LIFE TECHNOLOGIES HOLDINGS PTE LIMITED, LIFE TECHNOLOGIES CORPORATIONInventors: Kuan Moon Boo, Wei Fuh Teo, Zeqi Tan, Soo Yong Lau, Ming Tiong Sia, Woon Liang Soh, Ching Yee Lam, Shan Hua Dong, Marc Haberstroh, Michael C. Pallas, Hardeep Sangha
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Patent number: 11467092Abstract: An instrument for processing and/or measuring a biological process contains a sample processing system, an excitation source, an excitation optical system, an optical sensor, and an emission optical system. The sample processing system is configured to retain a first sample holder and a second sample holder, wherein the number of sample cells is different for each sample holder or a characteristic dimension for the first sample cells is different from that of the second sample holder. The instrument also includes an excitation source temperature controller comprising a temperature sensor that is coupled to the excitation source. The temperature controller is configured to produce a first target temperature when the first sample holder is retained by the instrument and to produce a second target temperature when the second sample holder is retained by the instrument.Type: GrantFiled: February 21, 2020Date of Patent: October 11, 2022Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Mingsong Chen, Mauro Aguanno, Kuan Moon Boo, Woon Liang Terence Soh, Jacob K. Freudenthal, Jeffrey A. Marks
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Publication number: 20220205915Abstract: A biological analysis system can include an excitation module and an emission module. The excitation module can include a collimator element for receiving excitation light from the excitation light source and transmitting collimated excitation light in a first direction, and a plurality of excitation mirrors arrayed along the excitation light path, each excitation mirror disposed at an acute angle relative to the first direction and configured to reflect collimated excitation light along a second direction. The emission module can be positioned to receive excitation light transmitted along the second direction and can include a sample block comprising a plurality of sample receptacles positioned to receive a beam of collimated excitation light, and a plurality of photodetectors configured to receive emission light transmitted from a respective sample receptacle in a direction transverse to the second direction of the excitation light path.Type: ApplicationFiled: January 11, 2022Publication date: June 30, 2022Inventors: Ming Song CHEN, Chee Woei CHONG, Wuh Ken LOH, WERN YUH FOO, Kuan Moon BOO, Norbert LECLERC, Kristina UHLENDORF, Reiner KOELLNER, Torsten FUCHS, Stefan BREITFELDER
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Patent number: 11339425Abstract: A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lends can be a bi-convex lens.Type: GrantFiled: April 12, 2019Date of Patent: May 24, 2022Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Jacob K. Freudenthal, Geoffrey Dahlhoff, Kevin Maher, Ming Song Chen, Gary Lim, Ronald Danehy, David Fortescue, Ming Shen, Woon Liang Soh, Francis T. Cheng, Ruoyun Wu, Thiam Chye Lee, Gary A. Chappell, Chee Kiong Lim, Jeff Dere, Ted Straub, Jorge Fonseca, Kuan Moon Boo, Soo Yong Lau
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Patent number: 11237108Abstract: A biological analysis system can include an excitation module and an emission module. The excitation module can include a collimator element for receiving excitation light from the excitation light source and transmitting collimated excitation light in a first direction, and a plurality of excitation mirrors arrayed along the excitation light path, each excitation mirror disposed at an acute angle relative to the first direction and configured to reflect collimated excitation light along a second direction. The emission module can be positioned to receive excitation light transmitted along the second direction and can include a sample block comprising a plurality of sample receptacles positioned to receive a beam of collimated excitation light, and a plurality of photodetectors configured to receive emission light transmitted from a respective sample receptacle in a direction transverse to the second direction of the excitation light path.Type: GrantFiled: June 18, 2020Date of Patent: February 1, 2022Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Ming Song Chen, Chee Woei Chong, Wuh Ken Loh, Wern Yuh Foo, Kuan Moon Boo, Norbert Leclerc, Kristina Uhlendorf, Reiner Koellner, Torsten Fuchs, Stefan Breitfelder
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Publication number: 20210214771Abstract: An instrument for biological analysis includes a base, an excitation source, an optical sensor, an excitation optical system, and an emission optical system. The base is configured to receive a sample holder comprising a plurality of biological samples. The optical sensor is configured to receive emissions from the biological samples in response to the excitation source. The instrument may additionally include a sensor lens enclosed by a lens case and a focusing mechanism including a gear that engages the lens case, the focusing mechanism being accessible outside the enclosure for adjusting a focus. The may instrument further include a sensor aperture dispose along an emission optical path and a blocking structure disposed to cooperate with the sensor aperture such that none of the reflected radiation from an illuminated surface near the sample holder is received by the optical sensor that does not also reflect off another surface of the instrument.Type: ApplicationFiled: January 18, 2021Publication date: July 15, 2021Inventors: Mingsong CHEN, Kuan Moon BOO, Tiong Han TOH, Mauro AGUANNO, Soo Yong LAU, Huei YEO, Wei Fuh TEO
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Publication number: 20200400569Abstract: A biological analysis system can include an excitation module and an emission module. The excitation module can include a collimator element for receiving excitation light from the excitation light source and transmitting collimated excitation light in a first direction, and a plurality of excitation mirrors arrayed along the excitation light path, each excitation mirror disposed at an acute angle relative to the first direction and configured to reflect collimated excitation light along a second direction. The emission module can be positioned to receive excitation light transmitted along the second direction and can include a sample block comprising a plurality of sample receptacles positioned to receive a beam of collimated excitation light, and a plurality of photodetectors configured to receive emission light transmitted from a respective sample receptacle in a direction transverse to the second direction of the excitation light path.Type: ApplicationFiled: June 18, 2020Publication date: December 24, 2020Inventors: Ming Song CHEN, Chee Woei CHONG, Wuh Ken LOH, Wern Yuh FOO, Kuan Moon BOO, Norbert LECLERC, Kristina UHLENDORF, Reiner KOELLNER, Torsten FUCHS, Stefan BREITFELDER
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Publication number: 20200241023Abstract: A system for biological analysis includes a housing, a block assembly within the housing having a sample block and a baseplate, a heated cover and a cover carrier. The sample block receives a sample holder comprising an RFID tag. A first drive mechanism generates relative movement between the sample block and the baseplate along a first axis. A second drive mechanism generates relative movement between the heated cover and the cover carrier along a second axis that is different from the first axis. Based on a first command the first drive mechanism releasably engages the sample block and operates the second drive mechanism to releasably engage the heated cover with the cover carrier. The system also includes first and second RFID antennas that receive RFID data from the sample holder RFID tag that is read by at least one RFID reader.Type: ApplicationFiled: January 30, 2020Publication date: July 30, 2020Inventors: Kuan Moon BOO, Wei Fuh TEO, Zeqi TAN, Soo Yong LAU, Ming Tiong SIA, Woon Liang SOH, Ching Yee LAM, Shan Hua DONG, Marc HABERSTROH, Michael C. PALLAS, Hardeep Sangha
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Publication number: 20200191719Abstract: An instrument for processing and/or measuring a biological process contains a sample processing system, an excitation source, an excitation optical system, an optical sensor, and an emission optical system. The sample processing system is configured to retain a first sample holder and a second sample holder, wherein the number of sample cells is different for each sample holder or a characteristic dimension for the first sample cells is different from that of the second sample holder. The instrument also includes an excitation source temperature controller comprising a temperature sensor that is coupled to the excitation source. The temperature controller is configured to produce a first target temperature when the first sample holder is retained by the instrument and to produce a second target temperature when the second sample holder is retained by the instrument.Type: ApplicationFiled: February 21, 2020Publication date: June 18, 2020Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Mingsong CHEN, Mauro AGUANNO, Kuan Moon BOO, Woon Liang Terence SOH, Jacob K. FREUDENTHAL, Jeffrey A. MARKS