Patents by Inventor Kuang-Yuh Chyu

Kuang-Yuh Chyu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NANOPARTICLE VACCINES AND USES THEREOF FOR PROPHYLAXIS AND TREATMENT OF ATHEROSCLEROSIS USING PEPTIDE 210 AS AN ANTIGEN
    Publication number: 20230355763
    Abstract: Described herein are nanoparticle bound self-antigens as an immune and vaccine formulations to elicit self-regulations and reduce atherosclerosis. The use of apolipoprotein B100 (ApoB-100) peptide P210 was investigated in self-assembling peptide amphiphile micelles (P210-PAM) as a vaccine formulation to reduce atherosclerosis in ApoE?/? mice. Demonstrated herein, P210 provided T cell activation and memory response in peripheral blood mononuclear cells of human subjects with atherosclerotic cardiovascular disease, and dendritic cell uptake of P210-PAM and its co-staining with major histocompatibility complex class I (MHC-I) molecules supported its use as an immunogenic composition. In ApoE?/? mice, immunization with P210-PAM dampened P210-specific CD4+ T cell proliferative response and CD8+ T cell cytolytic response, modulated macrophage phenotype, and significantly reduced aortic atherosclerosis. P210-PAM immunization also reduced atherosclerosis in chimeric mice with human MHC-I allele.
    Type: Application
    Filed: May 4, 2023
    Publication date: November 9, 2023
    Applicants: CEDARS-SINAI MEDICAL CENTER, University of Southern California
    Inventors: Prediman K. Shah, Kuang-Yuh Chyu, Eun Ji Chung, Noah Trac
  • Methods for treating kidney disease with fragments of ApoB-100
    Patent number: 9221876
    Abstract: The invention provides compositions comprising immunogenic fragments of ApoB-100 for eliciting an immune response in a subject or vaccinating a subject, so as to treat, prevent, 5 inhibit and/or reduce symptoms of kidney diseases in the subject. The compositions include immunogenic fragments of ApoB-100, CD8+ T cells activated with immunogenic fragments of ApoB-100 or a combination thereof.
    Type: Grant
    Filed: November 6, 2012
    Date of Patent: December 29, 2015
    Assignee: CardioVax, LLC
    Inventors: Kuang-Yuh Chyu, Prediman K. Shah, Paul Dimayuga
  • Immunomodulatory methods and systems for treatment and/or prevention of aneurysms
    Patent number: 9205139
    Abstract: Immunomodulatory agents, T cell, compositions, methods and systems for treating and/or preventing an aneurysm and/or a condition associated thereto in an individual.
    Type: Grant
    Filed: November 11, 2011
    Date of Patent: December 8, 2015
    Assignee: CardioVax, LLC
    Inventors: Prediman K. Shah, Kuang-Yuh Chyu, Tomoyuki Honjo
  • Immunomodulatory methods and systems for treatment and/or prevention of hypertension
    Patent number: 9205141
    Abstract: Immunomodulatory agents, T cell, compositions, methods and systems for treating and/or preventing hypertension and/or a condition associated thereto in an individual.
    Type: Grant
    Filed: November 11, 2011
    Date of Patent: December 8, 2015
    Assignee: Cardio Vax, LLC
    Inventors: Kuang-Yuh Chyu, Prediman K. Shah
  • Immunomodulatory methods and systems for treatment and/or prevention of atherosclerosis
    Patent number: 9125850
    Abstract: Immunostimulatory methods and systems for treating or preventing atherosclerosis and/or a condition associated thereto in an individual.
    Type: Grant
    Filed: November 12, 2010
    Date of Patent: September 8, 2015
    Assignee: Cardio Vax, LLC
    Inventors: Kuang-Yuh Chyu, Prediman K. Shah
  • COMPOSITIONS AND METHODS FOR TREATMENT OF KIDNEY DISEASES
    Publication number: 20140308306
    Abstract: The invention provides compositions comprising immunogenic fragments of ApoB-100 for eliciting an immune response in a subject or vaccinating a subject, so as to treat, prevent, 5 inhibit and/or reduce symptoms of kidney diseases in the subject. The compositions include immunogenic fragments of ApoB-100, CD8+ T cells activated with immunogenic fragments of ApoB-100 or a combination thereof.
    Type: Application
    Filed: November 6, 2012
    Publication date: October 16, 2014
    Applicant: CEDARS-SINAI MEDICAL CENTER
    Inventors: Kuang-Yuh Chyu, Prediman K. Shah, Paul Dimayuga
  • Immunomodulatory Compositions, Methods and Systems Comprising Immunogenic Fragments of ApoB-100
    Publication number: 20130302362
    Abstract: Immunostimulatory agents, T cell, compositions, methods and systems for treating and/or preventing various conditions in a human individual.
    Type: Application
    Filed: November 11, 2011
    Publication date: November 14, 2013
    Applicant: CEDARS-SINAI MEDICAL CENTER
    Inventors: Prediman K. Shah, Kuang-Yuh Chyu
  • Immunomodulatory Methods and Systems for Treatment and/or Prevention of Aneurysms
    Publication number: 20130236418
    Abstract: Immunomodulatory agents, T cell, compositions, methods and systems for treating and/or preventing an aneurysm and/or a condition associated thereto in an individual.
    Type: Application
    Filed: November 11, 2011
    Publication date: September 12, 2013
    Applicant: CEDARS-SINAI MEDICAL CENTER
    Inventors: Prediman K. Shah, Kuang-Yuh Chyu, Tomoyuki Honjo
  • Immunomodulatory Methods and Systems for Treatment and/or Prevention of Hypertension
    Publication number: 20130230487
    Abstract: Immunomodulatory agents, T cell, compositions, methods and systems for treating and/or preventing hypertension and/or a condition associated thereto in an individual.
    Type: Application
    Filed: November 11, 2011
    Publication date: September 5, 2013
    Applicant: CEDARS-SINAI MEDICAL CENTER
    Inventors: Kuang-Yuh Chyu, Prediman K. Shah
  • Immunomodulatory Methods and Systems for Treatment and/or Prevention of Atherosclerosis
    Publication number: 20120311729
    Abstract: Immunostimulatory methods and systems for treating or preventing atherosclerosis and/or a condition associated thereto in an individual.
    Type: Application
    Filed: November 12, 2010
    Publication date: December 6, 2012
    Inventors: Kuang-Yuh Chyu, Prediman K. Shah