Patents by Inventor Kuen-Feng Chen

Kuen-Feng Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for ameliorating fibrosis using 1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[3-(4-cyanophenoxy)phenyl]urea
    Patent number: 10993923
    Abstract: The present invention provides an application of 1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[3-(4-cyanophenoxy)phenyl]urea in preparation of drugs for treating and reducing a fibrotic disease. The fibrotic disease is skin sclerosis, cardiac fibrosis, pulmonary fibrosis, hepatic fibrosis, pancreatic fibrosis, or renal fibrosis.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: May 4, 2021
    Inventors: Kuen-Feng Chen, Chung-Wai Shiau
  • Agonists of protein tyrosine phosphatase SHP-1
    Patent number: 10745346
    Abstract: Some novel compounds are provided in this disclosure. These novel compounds have potential SHP-1 agonist activity for being used in treating cancer.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: August 18, 2020
    Inventors: Kuen-Feng Chen, Chung-Wai Shiau
  • METHOD FOR AMELIORATING FIBROSIS USING 1-[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]-3-[3-(4-CYANOPHENOXY)PHENYL]UREA
    Publication number: 20200016100
    Abstract: The present invention provides an application of 1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[3-(4-cyanophenoxy)phenyl]urea in preparation of drugs for treating and reducing a fibrotic disease. The fibrotic disease is skin sclerosis, cardiac fibrosis, pulmonary fibrosis, hepatic fibrosis, pancreatic fibrosis, or renal fibrosis.
    Type: Application
    Filed: September 22, 2017
    Publication date: January 16, 2020
    Inventors: Kuen-Feng CHEN, Chung-Wai SHIAU
  • Aryl amine substituted quinoxaline used as anticancer drugs
    Patent number: 10189795
    Abstract: The present invention provides new compounds of formula I(a)-I(d) and II, The compounds can inhibit cancerous inhibitor of protein phosphate 2A (CIP2A), can be used as protein phosphate 2A (PP2A) accelerator and oncoprotein SET antagonist, and can treat cancers effectively.
    Type: Grant
    Filed: July 7, 2015
    Date of Patent: January 29, 2019
    Inventors: Kuen-Feng Chen, Chung-Wai Shiau
  • AGONISTS OF PROTEIN TYROSINE PHOSPHATASE SHP-1
    Publication number: 20180237385
    Abstract: Some novel compounds are provided in this disclosure. These novel compounds have potential SHP-1 agonist activity for being used in treating cancer.
    Type: Application
    Filed: August 31, 2016
    Publication date: August 23, 2018
    Inventors: KUEN-FENG CHEN, CHUNG-WAI SHIAU
  • ARYL AMINE SUBSTITUTED QUINOXALINE USED AS ANTICANCER DRUGS
    Publication number: 20170204071
    Abstract: The present invention provides new compounds of formula I(a)-I(d) and II, The compounds can inhibit cancerous inhibitor of protein phosphate 2A (CIP2A), can be used as protein phosphate 2A (PP2A) accelerator and oncoprotein SET antagonist, and can treat cancers effectively.
    Type: Application
    Filed: July 7, 2015
    Publication date: July 20, 2017
    Inventors: KUEN-FENG CHEN, CHUNG-WAI SHIAU
  • Aryl amine substituted pyrimidine and quinazoline and their use as anticancer drugs
    Patent number: 9394261
    Abstract: A series of mono- and di-substituted quinazoline and pyrimidine derivatives based on the skeleton of erlotinib (an EGFR inhibitor) were synthesized and their bioactivities against hepatocellular carcinoma and human lung adenocarcinoma were evaluated.
    Type: Grant
    Filed: February 25, 2015
    Date of Patent: July 19, 2016
    Assignees: NATIONAL YANG-MING UNIVERSITY, NATIONAL TAIWAN UNIVERSITY
    Inventors: Chung-Wai Shiau, Kuen-Feng Chen
  • Agonists of Src homology-2 containing protein tyrosine phosphatase-1 and treatment methods using the same
    Patent number: 9216950
    Abstract: The present invention provides new compounds of formula I, II or III, which have Src homology-2 containing protein tyrosine phosphatase-1 (SHP-1) agonist activity. Also provided are treatment methods using the compounds of formula I, II or III.
    Type: Grant
    Filed: August 3, 2012
    Date of Patent: December 22, 2015
    Assignees: NATIONAL TAIWAN UNIVERSITY, NATIONAL YANG-MING UNIVERSITY, DCB-USA LLC
    Inventors: Chung-Wai Shiau, Kuen-Feng Chen
  • ARYL AMINE SUBSTITUTED PYRIMIDINE AND QUINAZOLINE AND THEIR USE AS ANTICANCER DRUGS
    Publication number: 20150246891
    Abstract: A series of mono- and di-substituted quinazoline and pyrimidine derivatives based on the skeleton of erlotinib (an EGFR inhibitor) were synthesized and their bioactivities against hepatocellular carcinoma and human lung adenocarcinoma were evaluated.
    Type: Application
    Filed: February 25, 2015
    Publication date: September 3, 2015
    Inventors: Chung-Wai SHIAU, Kuen-Feng CHEN
  • Agonists of Src homology-2 containing protein tyrosine phosphatase-1 and treatment methods using the same
    Patent number: 9090617
    Abstract: The present invention provides new compounds of formula I, II or III, which have Src homology-2 containing protein tyrosine phosphatase-1 (SHP-1) agonist activity. Also provided are treatment methods using the compounds of formula I, II or III.
    Type: Grant
    Filed: March 23, 2015
    Date of Patent: July 28, 2015
    Assignees: NATIONAL TAIWAN UNIVERSITY, NATIONAL YANG-MING UNIVERSITY, DCB-USA LLC
    Inventors: Chung-Wai Shiau, Kuen-Feng Chen
  • AGONISTS OF SRC HOMOLOGY-2 CONTAINING PROTEIN TYROSINE PHOSPHATASE-1 AND TREATMENT METHODS USING THE SAME
    Publication number: 20150191467
    Abstract: The present invention provides new compounds of formula I, II or III, which have Src homology-2 containing protein tyrosine phosphatase-1 (SHP-1) agonist activity. Also provided are treatment methods using the compounds of formula I, II or III.
    Type: Application
    Filed: March 23, 2015
    Publication date: July 9, 2015
    Inventors: Chung-Wai SHIAU, Kuen-Feng CHEN
  • AGONISTS OF SRC HOMOLOGY-2 CONTAINING PROTEIN TYROSINE PHOSPHATASE-1 AND TREATMENT METHODS USING THE SAME
    Publication number: 20140200239
    Abstract: The present invention provides new compounds of formula I, II or III, which have Src homology-2 containing protein tyrosine phosphatase-1 (SHP-1) agonist activity. Also provided are treatment methods using the compounds of formula I, II or III.
    Type: Application
    Filed: August 3, 2012
    Publication date: July 17, 2014
    Applicant: National Taiwan University
    Inventors: Chung-Wai Shiau, Kuen-Feng Chen
  • ARYL AMINE SUBSTITUTED PYRIMIDINE AND QUINAZOLINE AND THEIR USE AS ANTICANER DRUGS
    Publication number: 20140080848
    Abstract: A series of mono- and di-substituted quinazoline and pyrimidine derivatives based on the skeleton of erlotinib (an EGFR inhibitor) were synthesized and their bioactivities against hepatocellular carcinoma and human lung adenocarcinoma were evaluated.
    Type: Application
    Filed: September 13, 2013
    Publication date: March 20, 2014
    Applicants: National Taiwan University, National Yang-Ming University
    Inventors: Chung-Wai SHIAU, Kuen-Feng CHEN
  • Compact assembly configuration and process for reducing lead wire connections and solder joints
    Patent number: 5986912
    Abstract: The present invention discloses an electronic device for rectifying input electric signals to generate rectified output signals. The electronic device includes an input inductive circuit includes an input conductive winding-trace for receiving the input electric signals. The electronic device further includes a rectifying integrated circuit (IC) chip directly soldered onto to the winding-trace for processing the input electric signals provided for generating the rectified output signals. In another preferred embodiment, the input inductive circuit is an input one-turn inductive circuit further includes a top core and a bottom core for generating inductive input signals responding to the input electric signals. In another preferred embodiment, the electronic device further includes an output circuit connected to the IC chip wherein the output circuit further includes output inductive circuit for generating inductive output signals in response to the rectified output signals.
    Type: Grant
    Filed: December 22, 1998
    Date of Patent: November 16, 1999
    Assignee: Delta Electronics Inc.
    Inventors: Ko-Yu Hsiao, Kuen-Feng Chen, Kai-Hung Huang