Abstract: Provided are compounds, compositions and methods for treating Toll-like receptor 1/2 complex (TLRI/2) related inflammatory disorders. Small molecules, based on the benzotropolone scaffold, capable of influencing downstream signaling are disclosed as well as methods of making and modifying these molecules. Also provided are methods for treating a subject for a clinical condition associated with Toll-like receptor complex 1/2 activation, comprising administering to the subject an effective amount of a benzotropolone compound.

Abstract: With the growing number of downloaded applications on devices, especially on ones with limited screen real estate, users need a quick and pain-free way to locate applications. In accordance with one or more embodiments of the present invention, a system and methods are provided for generating an application selection recommendation.

Abstract: A system and method are provided for automatic fitting of all audio signals according to the ear in which a user is using to receive audio signals from a host device. The device may comprise an inquirer configured to query a host device for an in-use audio producing transducer; an electronic mechanism configured to identify an ear which a user is using to receive audio signals from a host device, based on the in-use audio producing transducer; and a notifier configured to instruct the host device, based on the identified ear, to output a channel of audio signals to the in-use audio producing transducer. The ear in use may be deduced from inertial data. The instructions may specify a particular channel of audio signals, or enhancement thereof, based on characteristics of the identified ear and/or a detected or typical signal pathway used to transmit a signal to the identified ear.

Abstract: A system and method are provided for capturing hearing characteristics from self-administered hearing tests, including loudness tolerance levels at different sound frequencies, as an individualized shaped auditory profile for automatically enhancing audio to complement and address as closely as possible an individual's hearing deficits experienced via a particular signal pathway, the signal pathway including the audio device used to administer the test, the sound environment, and the user's hearing capabilities. The user may self-administer a hearing test on a convenient personal apparatus, such as a smartphone. The shaped auditory profile may then be used to produce enhanced sound subsequently transmitted to the individual via the same signal pathway. In certain of its aspects, the invention is useful for any individual seeking an enhanced hearing experience, whether having hearing within normal range or hearing that is impaired.

Abstract: The present invention provides compounds and compositions that can modulate formation of Toll-like receptor 3 (TLR3) and double-stranded RNA (dsRNA) complex, and methods for using the same. In particular, some aspects of the invention provide compounds of the formula: compositions comprising and methods for using the same, where n, Ar1, Ar2, X1, X2, X3, Z1, and Z2 are those defined herein.

Abstract: A system and method are provided for capturing hearing characteristics from self-administered hearing tests or from professionally administered hearing tests, including loudness tolerance levels as at different sound frequencies, as an individualized audiological profile for automatically enhancing audio to complement and address as closely as possible an individual's hearing deficits. The user may self-administer a hearing test on a convenient personal apparatus, such as a smartphone. The system includes the ability for capturing an environment profile. The user's hearing is protected against harm in the enhanced audio setting while being provided with the option of a “enhanced hearing” experience. The invention is useful for any individual seeking an enhanced hearing experience, whether having hearing within normal range or hearing that is impaired. Thus the system is useful as a hearing aid.

Abstract: A plurality of sheet panels of a mobile is suspended for multiple freedoms of movement from a support mountable on a horizontal supporting surface. The support is unfoldable from a compact position suitable for storage and transport to a display position in which the sheet panels of the mobile display a greeting card message.

Abstract: A greeting card is suspended for multiple freedoms of movement from an overhead support mountable on different supporting surfaces.

Abstract: A bouquet of flowers is wrapped with a leaf-shaped sheet that creates a floral presentation having a common floral theme.