Abstract: The present invention provides hTERT modulators and methods for producing and using the same. In particular, the present invention provide a compound of the formula as described herein. Some aspects of the invention are based on the characterization of the effect of hTERT core promoter region mutants on the 5-12 G-quadruplex structure and its stability. It is believed that some of the compounds of the invention bind selectively to the G-quadruplex in the hTERT core promoter mutant, which results in reversal of the effect of mutant promoter activation.

Abstract: Technologies for performing non-intrusive fine-grained power monitoring of a datacenter are provided. Hardware component state information for servers in the datacenter is collected, along with aggregate power consumption measurements for the datacenter. The servers are grouped into multiple virtual homogenous server clusters (VHCs) based on characteristics of the servers. A power model is constructed comprising multiple power mapping functions associated with the multiple VHCs. Component state information of a particular server can then be analyzed, along with a corresponding aggregate power consumption measurement, using the constructed power model to determine an approximate power consumption of the particular server. The approximate power consumption of the server can then be displayed and/or provided to one or more power management applications.

Abstract: The present invention provides hTERT modulators and methods for producing and using the same. In particular, the present invention provide a compound of the formula as described herein. Some aspects of the invention are based on the characterization of the effect of hTERT core promoter region mutants on the 5-12 G-quadruplex structure and its stability. It is believed that some of the compounds of the invention bind selectively to the G-quadruplex in the hTERT core promoter mutant, which results in reversal of the effect of mutant promoter activation.

Abstract: A system and method for managing an electrical distribution system in a facility is disclosed. In one aspect, the method may include receiving at a computer system from a monitoring system data related to actual energy use of components of the electrical distribution system, receiving at the computer system a request for a modification to the electrical distribution system, using the computer system, providing a revised electrical distribution system design based on the request and the data related to actual energy use using a system optimization function for the electrical distribution system, modifying the electrical distribution system in accordance with the revised electrical distribution system design to provide a modified electrical distribution system in the facility, and receiving at the computer system from the monitoring system data related to actual energy use of components of the modified electrical distribution system.

Abstract: An integrated lens with integrated functional optical surfaces for use in optical communication is disclosed. The integrated lens includes first and second cavities and a fiber adapter. The device also includes integrated first and second lenses. The first cavity houses one or more optical transmitting and/or receiving devices. The second cavity has a first optical surface and an optional second optical surface. The fiber adapter has the second lens. The integrated lens enables a small size, a light weight, high coupling and a high transmission efficiency, and can be produced by injection molding using a single mold. The integrated lens is applicable to optical signal coupling, fiber connections, optical modules, and optical or optoelectronic communication.

Abstract: An integrated lens with integrated functional optical surfaces for use in optical communication is disclosed. The integrated lens includes first and second cavities and a fiber adapter. The device also includes integrated first and second lenses. The first cavity houses one or more optical transmitting and/or receiving devices. The second cavity has a first optical surface and an optional second optical surface. The fiber adapter has the second lens. The integrated lens enables a small size, a light weight, high coupling and a high transmission efficiency, and can be produced by injection molding using a single mold. The integrated lens is applicable to optical signal coupling, fiber connections, optical modules, and optical or optoelectronic communication.

Abstract: The present invention relates to an oxo indirubin or isoindigo derivative, an oxo aza indirubin or isoindigo derivative, and their optical isomers, racemes, cis/trans isomers and pharmaceutically acceptable salts, which can be used for preparing a drug for treating or preventing diseases such as glucose metabolic disorder, inflammatory or autoimmune disease, neurodegenerative disease, a mental illness, tissue proliferation disease or tumors.

Abstract: Technologies for performing non-intrusive fine-grained power monitoring of a datacenter are provided. Hardware component state information for servers in the datacenter is collected, along with aggregate power consumption measurements for the datacenter. The servers are grouped into multiple virtual homogenous server clusters (VHCs) based on characteristics of the servers. A power model is constructed comprising multiple power mapping functions associated with the multiple VHCs. Component state information of a particular server can then be analyzed, along with a corresponding aggregate power consumption measurement, using the constructed power model to determine an approximate power consumption of the particular server. The approximate power consumption of the server can then be displayed and/or provided to one or more power management applications.

Abstract: An N×N parallel optical transceiver includes a printed circuit board, a laser driving control chip, one or more lasers, two GRIN lenses, an optical band-pass filter, a multimode fiber array and a photodiode array. In the transmitter, laser beams of the same wavelength simultaneously output from the laser chip are first focused by the first GRIN lens, then the beams pass through a wavelength band-pass filter and are refocused by the second GRIN lens, and enter the channels in the multimode fiber array. In the receiver, laser beams of a different wavelength from the multimode fiber array are focused by the second GRIN lens, then reflected by the band-pass filter, refocused by the second GRIN lens, and received by the photodiode array. The multi-channel parallel transceiver has a small form, and can integrate a DFB or FP laser chip and GRIN lenses.

Abstract: A high speed optical module, and in particular, a multi-channel, single-mode, parallel transmission optical module in the field of optical communication is disclosed. The optical module includes a chassis, a first transmitter optical subassembly (TOSA), a second transmitter optical subassembly (TOSA), a third transmitter optical subassembly (TOSA), a fourth transmitter optical subassembly (TOSA) and a MT fiber connector. The TOSA may be a TO-38 TOSA of a 10 G DFB chip or FP chip. With single-mode communication, the optical module provides a transmission distance over 10 kilometers. In addition, to make coupling single-mode fibers easier, a twelve-core MT fiber connector is employed, wherein four fiber connectors are respectively connected to LC standard fiber stubs and the outputs of the TOSAs accordingly. Thus, the optical module further provides high speed and long-distance transmission, large capacity, small volume, and light weight and can be broadly applied to high speed optical communications.

Abstract: An N×N parallel optical transceiver includes a printed circuit board, a laser driving control chip, one or more lasers, two GRIN lenses, an optical band-pass filter, a multimode fiber array and a photodiode array. In the transmitter, laser beams of the same wavelength simultaneously output from the laser chip are first focused by the first GRIN lens, then the beams pass through a wavelength band-pass filter and are refocused by the second GRIN lens, and enter the channels in the multimode fiber array. In the receiver, laser beams of a different wavelength from the multimode fiber array are focused by the second GRIN lens, then reflected by the band-pass filter, refocused by the second GRIN lens, and received by the photodiode array. The multi-channel parallel transceiver has a small form, and can integrate a DFB or FP laser chip and GRIN lenses.

Abstract: An integrated lens with integrated functional optical surfaces for use in optical communication is disclosed. The integrated lens includes first and second cavities and a fiber adapter. The device also includes integrated first and second lenses. The first cavity houses one or more optical transmitting and/or receiving devices. The second cavity has a first optical surface and an optional second optical surface. The fiber adapter has the second lens. The integrated lens enables a small size, a light weight, high coupling and a high transmission efficiency, and can be produced by injection molding using a single mold. The integrated lens is applicable to optical signal coupling, fiber connections, optical modules, and optical or optoelectronic communication.

Abstract: An integrated lens with integrated functional optical surfaces for use in optical communication is disclosed. The integrated lens includes first and second cavities and a fiber adapter. The device also includes integrated first and second lenses. The first cavity houses one or more optical transmitting and/or receiving devices. The second cavity has a first optical surface and an optional second optical surface. The fiber adapter has the second lens. The integrated lens enables a small size, a light weight, high coupling and a high transmission efficiency, and can be produced by injection molding using a single mold. The integrated lens is applicable to optical signal coupling, fiber connections, optical modules, and optical or optoelectronic communication.

Abstract: A high speed optical module, and in particular, a multi-channel, single-mode, parallel transmission optical module in the field of optical communication is disclosed. The optical module includes a chassis, a first transmitter optical subassembly (TOSA), a second transmitter optical subassembly (TOSA), a third transmitter optical subassembly (TOSA), a fourth transmitter optical subassembly (TOSA) and a MT fiber connector. The TOSA may be a TO-38 TOSA of a 10 G DFB chip or FP chip. With single-mode communication, the optical module provides a transmission distance over 10 kilometers. In addition, to make coupling single-mode fibers easier, a twelve-core MT fiber connector is employed, wherein four fiber connectors are respectively connected to LC standard fiber stubs and the outputs of the TOSAs accordingly. Thus, the optical module further provides high speed and long-distance transmission, large capacity, small volume, and light weight and can be broadly applied to high speed optical communications.

Abstract: The present invention relates to an oxo indirubin or isoindigo derivative, an oxo aza indirubin or isoindigo derivative, and their optical isomers, racemes, cis/trans isomers and pharmaceutically acceptable salts, which can be used for preparing a drug for treating or preventing diseases such as glucose metabolic disorder, inflammatory or autoimmune disease, neurodegenerative disease, a mental illness, tissue proliferation disease or tumors.

Abstract: Provided are the method and device for genetic map construction and the method and device for haplotype determination of a single cell.

Abstract: Provided are a whole genome sample amplification method, a whole genome sequencing method, and a method for determining whether an abnormal state occurs in a whole genome, a whole genome sample amplification apparatus, a whole genome sequencing device, and a system for determining whether an abnormal state occurs in a whole genome. The whole genome sample amplification method comprises: subjecting a whole genome sample to a first amplification reaction, so as to obtain a first amplification product; and subjecting the first amplification product to a second amplification reaction, so as to obtain a second amplification product. The first amplification reaction is one of the PCR-based amplification reaction and the isothermal amplification reaction, and the second amplification reaction is the other of the PCR-based amplification reaction and the isothermal amplification reaction.

Abstract: A system and method for managing an electrical distribution system in a facility is disclosed. In one aspect, the method may include receiving at a computer system from a monitoring system data related to actual energy use of components of the electrical distribution system, receiving at the computer system a request for a modification to the electrical distribution system, using the computer system, providing a revised electrical distribution system design based on the request and the data related to actual energy use using a system optimization function for the electrical distribution system, modifying the electrical distribution system in accordance with the revised electrical distribution system design to provide a modified electrical distribution system in the facility, and receiving at the computer system from the monitoring system data related to actual energy use of components of the modified electrical distribution system.

Abstract: Provided are the method and device for genetic map construction and the method and device for haplotype determination of a single cell.