Patents by Inventor Kuishu Ren
Kuishu Ren has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210301037Abstract: A compound comprising one or more polysaccharide moieties each independently represented by the formula ?(1?4)-[GlcNH—R]n-2,5-anhydromannose, wherein n is a positive integer from 3 to 500, and R is H or an acyl group, is described. The compound can be manufactured by (a) reacting chitosan with an acylating agent sufficient to partially N-acylate the chitosan, yielding a modified chitin/chitosan mixed polymer; and (b) reacting the modified chitin/chitosan mixed polymer with a deaminating agent to cleave the mixed polymer at the unacylated chitosan moieties. The compound can be used to immunize against fungal infection. Antibodies specific to the compound, and the use of such antibodies to protect against fungal infection are also described.Type: ApplicationFiled: March 23, 2021Publication date: September 30, 2021Inventors: Francis MICHON, Samuel J. WOHLSTADTER, Frank COMER, Kuishu REN
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Patent number: 10988552Abstract: A compound comprising one or more polysaccharide moieties each independently represented by the formula ?(1?4)-[GlcNH—R]n-2,5-anhydromannose, wherein n is a positive integer from 3 to 500, and R is H or an acyl group, is described. The compound can be manufactured by (a) reacting chitosan with an acylating agent sufficient to partially N-acylate the chitosan, yielding a modified chitin/chitosan mixed polymer; and (b) reacting the modified chitin/chitosan mixed polymer with a deaminating agent to cleave the mixed polymer at the unacylated chitosan moieties. The compound can be used to immunize against fungal infection. Antibodies specific to the compound, and the use of such antibodies to protect against fungal infection are also described.Type: GrantFiled: July 14, 2020Date of Patent: April 27, 2021Assignee: Wellstat Vaccines, LLCInventors: Francis Michon, Samuel J. Wohlstadter, Frank Comer, Kuishu Ren
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Publication number: 20200339707Abstract: A compound comprising one or more polysaccharide moieties each independently represented by the formula ?(1?4)-[GlcNH—R]n-2,5-anhydromannose, wherein n is a positive integer from 3 to 500, and R is H or an acyl group, is described. The compound can be manufactured by (a) reacting chitosan with an acylating agent sufficient to partially N-acylate the chitosan, yielding a modified chitin/chitosan mixed polymer; and (b) reacting the modified chitin/chitosan mixed polymer with a deaminating agent to cleave the mixed polymer at the unacylated chitosan moieties. The compound can be used to immunize against fungal infection. Antibodies specific to the compound, and the use of such antibodies to protect against fungal infection are also described.Type: ApplicationFiled: July 14, 2020Publication date: October 29, 2020Inventors: Francis MICHON, Samuel J. WOHLSTADTER, Frank COMER, Kuishu REN
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Patent number: 10752704Abstract: A compound comprising one or more polysaccharide moieties each independently represented by the formula ?(1?4)-[GlcNH—R]n-2,5-anhydromannose, wherein n is a positive integer from 3 to 500, and R is H or an acyl group, is described. The compound can be manufactured by (a) reacting chitosan with an acylating agent sufficient to partially N-acylate the chitosan, yielding a modified chitin/chitosan mixed polymer; and (b) reacting the modified chitin/chitosan mixed polymer with a deaminating agent to cleave the mixed polymer at the unacylated chitosan moieties. The compound can be used to immunize against fungal infection. Antibodies specific to the compound, and the use of such antibodies to protect against fungal infection are also described.Type: GrantFiled: October 29, 2019Date of Patent: August 25, 2020Assignee: Wellstat Vaccines, LLCInventors: Francis Michon, Samuel J. Wohlstadter, Frank Comer, Kuishu Ren
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Publication number: 20200062866Abstract: A compound comprising one or more polysaccharide moieties each independently represented by the formula ?(1?4)-[GlcNH—R]n-2,5-anhydromannose, wherein n is a positive integer from 3 to 500, and R is H or an acyl group, is described. The compound can be manufactured by (a) reacting chitosan with an acylating agent sufficient to partially N-acylate the chitosan, yielding a modified chitin/chitosan mixed polymer; and (b) reacting the modified chitin/chitosan mixed polymer with a deaminating agent to cleave the mixed polymer at the unacylated chitosan moieties. The compound can be used to immunize against fungal infection. Antibodies specific to the compound, and the use of such antibodies to protect against fungal infection are also described.Type: ApplicationFiled: October 29, 2019Publication date: February 27, 2020Inventors: Francis MICHON, Samuel J. WOHLSTADTER, Frank COMER, Kuishu REN
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Patent number: 10519253Abstract: A compound comprising one or more polysaccharide moieties each independently represented by the formula ?(1?4)-[GlcNH-R]n-2,5-anhydromannose, wherein n is a positive integer from 3 to 500, and R is H or an acyl group, is described. The compound can be manufactured by (a) reacting chitosan with an acylating agent sufficient to partially N-acylate the chitosan, yielding a modified chitin/chitosan mixed polymer; and (b) reacting the modified chitin/chitosan mixed polymer with a deaminating agent to cleave the mixed polymer at the unacylated chitosan moieties. The compound can be used to immunize against fungal infection. Antibodies specific to the compound, and the use of such antibodies to protect against fungal infection are also described.Type: GrantFiled: February 5, 2019Date of Patent: December 31, 2019Assignee: Wellstat Vaccines, LLCInventors: Francis Michon, Samuel J. Wohlstadter, Frank Comer, Kuishu Ren
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Publication number: 20190169315Abstract: A compound comprising one or more polysaccharide moieties each independently represented by the formula ?(1?4)-[GlcNH-R]n-2,5-anhydromannose, wherein n is a positive integer from 3 to 500, and R is H or an acyl group, is described. The compound can be manufactured by (a) reacting chitosan with an acylating agent sufficient to partially N-acylate the chitosan, yielding a modified chitin/chitosan mixed polymer; and (b) reacting the modified chitin/chitosan mixed polymer with a deaminating agent to cleave the mixed polymer at the unacylated chitosan moieties. The compound can be used to immunize against fungal infection. Antibodies specific to the compound, and the use of such antibodies to protect against fungal infection are also described.Type: ApplicationFiled: February 5, 2019Publication date: June 6, 2019Inventors: Francis MICHON, Samuel J. WOHLSTADTER, Frank COMER, Kuishu REN
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Patent number: 10259888Abstract: A compound comprising one or more polysaccharide moieties each independently represented by the formula ?(1?4)-[GlcNH—R]n-2,5-anhydromannose, wherein n is a positive integer from 3 to 500, and R is H or an acyl group, is described. The compound can be manufactured by (a) reacting chitosan with an acylating agent sufficient to partially N-acylate the chitosan, yielding a modified chitin/chitosan mixed polymer; and (b) reacting the modified chitin/chitosan mixed polymer with a deaminating agent to cleave the mixed polymer at the unacylated chitosan moieties. The compound can be used to immunize against fungal infection. Antibodies specific to the compound, and the use of such antibodies to protect against fungal infection are also described.Type: GrantFiled: May 1, 2017Date of Patent: April 16, 2019Assignee: Wellstat Vaccines, LLCInventors: Francis Michon, Samuel J. Wohlstadter, Frank Comer, Kuishu Ren
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Publication number: 20180251573Abstract: A compound comprising one or more polysaccharide moieties each independently represented by the formula ?(1?4)-[GlcNH-R]n-2,5-anhydromannose, wherein n is a positive integer from 3 to 500, and R is H or an acyl group, is described. The compound can be manufactured by (a) reacting chitosan with an acylating agent sufficient to partially N-acylate the chitosan, yielding a modified chitin/chitosan mixed polymer; and (b) reacting the modified chitin/chitosan mixed polymer with a deaminating agent to cleave the mixed polymer at the unacylated chitosan moieties. The compound can be used to immunize against fungal infection. Antibodies specific to the compound, and the use of such antibodies to protect against fungal infection are also described.Type: ApplicationFiled: May 1, 2017Publication date: September 6, 2018Inventors: Francis MICHON, Samuel J. WOHLSTADTER, Frank COMER, Kuishu REN
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Publication number: 20160017062Abstract: A compound comprising one or more polysaccharide moieties each independently represented by the formula ?(1?4)-[GlcNH—R]n-2,5-anhydromannose, wherein n is a positive integer from 3 to 500, and R is H or an acyl group, is described. The compound can be manufactured by (a) reacting chitosan with an acylating agent sufficient to partially N-acylate the chitosan, yielding a modified chitin/chitosan mixed polymer; and (b) reacting the modified chitin/chitosan mixed polymer with a deaminating agent to cleave the mixed polymer at the unacylated chitosan moieties. The compound can be used to immunize against fungal infection. Antibodies specific to the compound, and the use of such antibodies to protect against fungal infection are also described.Type: ApplicationFiled: March 6, 2014Publication date: January 21, 2016Applicant: Wellstat Vaccines, LLCInventors: Francis Michon, Frank Comer, Kuishu Ren