Patents by Inventor Kullervo Henrik Hynynen

Kullervo Henrik Hynynen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230397881
    Abstract: Systems, methods and devices are provided for performing diagnostic or therapeutic transcranial procedures using a patient-specific transcranial headset. The patient-specific headset may include a patient-specific frame that is fabricated, according to volumetric image data, to conform to an anatomical curvature of a portion of a patient's head. The patient-specific frame is configured to support a plurality of transducers in pre-selected positions and orientations, which may be spatially registered to the volumetric image data. This spatial registration may be employed to control at least a portion of the transducers to focus energy at a preselected tissue region.
    Type: Application
    Filed: August 29, 2023
    Publication date: December 14, 2023
    Inventor: KULLERVO HENRIK HYNYNEN
  • Patent number: 11771370
    Abstract: Systems, methods and devices are provided for performing diagnostic or therapeutic transcranial procedures using a patient-specific transcranial headset. The patient-specific headset may include a patient-specific frame that is fabricated, according to volumetric image data, to conform to an anatomical curvature of a portion of a patient's head. The patient-specific frame is configured to support a plurality of transducers in pre-selected positions and orientations, which may be spatially registered to the volumetric image data. This spatial registration may be employed to control at least a portion of the transducers to focus energy at a pre-selected tissue region.
    Type: Grant
    Filed: February 23, 2017
    Date of Patent: October 3, 2023
    Assignee: SUNNYBROOK RESEARCH INSTITUTE
    Inventor: Kullervo Henrik Hynynen
  • Patent number: 11744547
    Abstract: An ultrasound phased array transducer is disclosed that achieves suppression of grating lobes through the incorporation of a coupling layer, where the coupling layer is positioned adjacent to the phased array transducer such that an ultrasound beam propagates through the coupling layer prior to encountering a propagation medium. The phased-array elements may be provided such that one or both of the array pitch and a lateral extent of each ultrasound transducer element is larger than half of the ultrasound wavelength in the propagation medium. Grating lobes within the coupling layer and the propagation medium may be reduced or suppressed by selecting a coupling material having a speed of sound that exceeds that of the propagation medium. The coupling layer may have a thickness sufficient for the generation of a wavefront, and the coupling layer may be formed from a viscous or viscoelastic material.
    Type: Grant
    Filed: February 23, 2017
    Date of Patent: September 5, 2023
    Assignee: SUNNYBROOK RESEARCH INSTITUTE
    Inventor: Kullervo Henrik Hynynen
  • Publication number: 20230255597
    Abstract: A system and method for controlling the delivery of ultrasound energy to a subject is provided. In particular, such a system and method are capable of safely disrupting the blood-brain barrier. Ultrasound energy is delivered to produce cavitation of an ultrasound contrast agent at a selected pressure value. An acoustic signal is acquired following cavitation, from which a signal spectrum is produced. The signal spectrum is analyzed for the presence of harmonics, such as subharmonics or ultraharmonics. When subharmonics or ultraharmonics are present, the pressure value is decreased for subsequent sonications. If a previous sonication resulted in no subharmonics or ultraharmonics being generated, then the pressure value may be increased. In this manner, the blood-brain barrier can be advantageously disrupted while mitigating potentially injurious effects of the sonication.
    Type: Application
    Filed: September 6, 2022
    Publication date: August 17, 2023
    Inventors: Meaghan Anne O'Reilly, Kullervo Henrik Hynynen
  • Publication number: 20230191162
    Abstract: In at least some examples, a method of treating an eye, includes (i) imaging a patient's vitreous using a probe, (ii) defining a window on a desired region of the vitreous, (iii) administering ultrasonic energy treatment to the desired region within the window, (iv) continually monitoring the treatment via the probe, (v) adjusting a characteristic of the ultrasonic energy treatment based on the monitoring, (vi) re-imaging the desired region of the vitreous after the treatment is administered, and (vii) evaluating or observing the desired region to determine whether a target percentage of a vitreous opacity has been resolved.
    Type: Application
    Filed: February 10, 2023
    Publication date: June 22, 2023
    Applicants: Vitreosonic Inc., Sunnybrook Research Institute
    Inventors: Gary Lloyd Ka Tao Yau, Kullervo Henrik Hynynen
  • Patent number: 11464482
    Abstract: A system and method for efficiently transmitting and receiving focused ultrasound through a medium, such as bone, is provided. The focal region of the focused ultrasound is iteratively updated to provide an improved focus through the medium. This method may be carried out using a transducer assembly that includes two or more transmit arrays each operating at a different frequency. An initial focus is set and updated by delivering focused ultrasound with a lower frequency transmit array. The phase corrections determined in the first iteration are applied to subsequently higher frequency transmit arrays and received signals, and the process repeated until a desired focus or image resolution is achieved.
    Type: Grant
    Filed: March 4, 2014
    Date of Patent: October 11, 2022
    Assignee: Sunnybrook Research Institute
    Inventors: Kullervo Henrik Hynynen, Meaghan Anne O'Reilly
  • Patent number: 11432802
    Abstract: A system and method for controlling the delivery of ultrasound energy to a subject is provided. In particular, such a system and method are capable of safely disrupting the blood-brain barrier. Ultrasound energy is delivered to produce cavitation of an ultrasound contrast agent at a selected pressure value. An acoustic signal is acquired following cavitation, from which a signal spectrum is produced. The signal spectrum is analyzed for the presence of harmonics, such as subharmonics or ultraharmonics. When subharmonics or ultraharmonics are present, the pressure value is decreased for subsequent sonications. If a previous sonication resulted in no subharmonics or ultraharmonics being generated, then the pressure value may be increased. In this manner, the blood-brain barrier can be advantageously disrupted while mitigating potentially injurious effects of the sonication.
    Type: Grant
    Filed: July 6, 2020
    Date of Patent: September 6, 2022
    Assignee: SUNNYBROOK RESEARCH INSTITUTE
    Inventors: Meaghan Anne O'Reilly, Kullervo Henrik Hynynen
  • Publication number: 20200330075
    Abstract: A system and method for controlling the delivery of ultrasound energy to a subject is provided. In particular, such a system and method are capable of safely disrupting the blood-brain barrier. Ultrasound energy is delivered to produce cavitation of an ultrasound contrast agent at a selected pressure value. An acoustic signal is acquired following cavitation, from which a signal spectrum is produced. The signal spectrum is analyzed for the presence of harmonics, such as subharmonics or ultraharmonics. When subharmonics or ultraharmonics are present, the pressure value is decreased for subsequent sonications. If a previous sonication resulted in no subharmonics or ultraharmonics being generated, then the pressure value may be increased. In this manner, the blood-brain barrier can be advantageously disrupted while mitigating potentially injurious effects of the sonication.
    Type: Application
    Filed: July 6, 2020
    Publication date: October 22, 2020
    Inventors: Meaghan Anne O'Reilly, Kullervo Henrik Hynynen
  • Patent number: 10702244
    Abstract: A system and method for controlling the delivery of ultrasound energy to a subject is provided. In particular, such a system and method are capable of safely disrupting the blood-brain barrier. Ultrasound energy is delivered to produce cavitation of an ultrasound contrast agent at a selected pressure value. An acoustic signal is acquired following cavitation, from which a signal spectrum is produced. The signal spectrum is analyzed for the presence of harmonics, such as subharmonics or ultraharmonics. When subharmonics or ultraharmonics are present, the pressure value is decreased for subsequent sonications. If a previous sonication resulted in no subharmonics or ultraharmonics being generated, then the pressure value may be increased. In this manner, the blood-brain barrier can be advantageously disrupted while mitigating potentially injurious effects of the sonication.
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: July 7, 2020
    Assignee: SUNNYBROOK RESEARCH INSTITUTE
    Inventors: Meaghan Anne O'Reilly, Kullervo Henrik Hynynen
  • Patent number: 10576304
    Abstract: Apparatus and method for delivering increased amounts of energy to localized treatment zones in a target tissue volume are provided. In some instances the non-linear wave propagation and other properties of the treatment apparatus and propagation medium as well as novel beam forming and control of the treatment apparatus are employed to generate extended focal zones for efficient treatment of a condition in a patient.
    Type: Grant
    Filed: June 28, 2011
    Date of Patent: March 3, 2020
    Assignee: SUNNYBROOK RESEARCH INSTITUTE
    Inventor: Kullervo Henrik Hynynen
  • Publication number: 20190021666
    Abstract: Systems, methods and devices are provided for performing diagnostic or therapeutic transcranial procedures using a patient-specific transcranial headset. The patient-specific headset may include a patient-specific frame that is fabricated, according to volumetric image data, to conform to an anatomical curvature of a portion of a patient's head. The patient-specific frame is configured to support a plurality of transducers in pre-selected positions and orientations, which may be spatially registered to the volumetric image data. This spatial registration may be employed to control at least a portion of the transducers to focus energy at a pre-selected tissue region.
    Type: Application
    Filed: February 23, 2017
    Publication date: January 24, 2019
    Inventor: KULLERVO HENRIK HYNYNEN
  • Publication number: 20190000416
    Abstract: An ultrasound phased array transducer is disclosed that achieves suppression of grating lobes through the incorporation of a coupling layer, where the coupling layer is positioned adjacent to the phased array transducer such that an ultrasound beam propagates through the coupling layer prior to encountering a propagation medium. The phased-array elements may be provided such that one or both of the array pitch and a lateral extent of each ultrasound transducer element is larger than half of the ultrasound wavelength in the propagation medium. Grating lobes within the coupling layer and the propagation medium may be reduced or suppressed by selecting a coupling material having a speed of sound that exceeds that of the propagation medium. The coupling layer may have a thickness sufficient for the generation of a wavefront, and the coupling layer may be formed from a viscous or viscoelastic material.
    Type: Application
    Filed: February 23, 2017
    Publication date: January 3, 2019
    Inventor: KULLERVO HENRIK HYNYNEN
  • Publication number: 20160007954
    Abstract: A system and method for efficiently transmitting and receiving focused ultrasound through a medium, such as bone, is provided. The focal region of the focused ultrasound is iteratively updated to provide an improved focus through the medium. This method may be carried out using a transducer assembly that includes two or more transmit arrays each operating at a different frequency. An initial focus is set and updated by delivering focused ultrasound with a lower frequency transmit array. The phase corrections determined in the first iteration are applied to subsequently higher frequency transmit arrays and received signals, and the process repeated until a desired focus or image resolution is achieved.
    Type: Application
    Filed: March 4, 2014
    Publication date: January 14, 2016
    Inventors: Kullervo Henrik HYNYNEN, Meaghan Anne O'REILLY
  • Publication number: 20130006106
    Abstract: A system and method for controlling the delivery of ultrasound energy to a subject is provided. In particular, such a system and method are capable of safely disrupting the blood-brain barrier. Ultrasound energy is delivered to produce cavitation of an ultrasound contrast agent at a selected pressure value. An acoustic signal is acquired following cavitation, from which a signal spectrum is produced. The signal spectrum is analyzed for the presence of harmonics, such as subharmonics or ultraharmonics. When subharmonics or ultraharmonics are present, the pressure value is decreased for subsequent sonications. If a previous sonication resulted in no subharmonics or ultraharmonics being generated, then the pressure value may be increased. In this manner, the blood-brain barrier can be advantageously disrupted while mitigating potentially injurious effects of the sonication.
    Type: Application
    Filed: June 29, 2012
    Publication date: January 3, 2013
    Inventors: Meaghan Anne O'Reilly, Kullervo Henrik Hynynen
  • Publication number: 20110319793
    Abstract: Apparatus and method for delivering increased amounts of energy to localized treatment zones in a target tissue volume are provided. In some instances the non-linear wave propagation and other properties of the treatment apparatus and propagation medium as well as novel beam forming and control of the treatment apparatus are employed to generate extended focal zones for efficient treatment of a condition in a patient.
    Type: Application
    Filed: June 28, 2011
    Publication date: December 29, 2011
    Applicant: Sunnybrook Research Institute
    Inventor: Kullervo Henrik Hynynen
  • Patent number: 5873845
    Abstract: A system for performing surgery by vibrational heating employs an ultrasonic transducer 80 for focusing a spherical ultrasound wave on a focal region. In one embodiment a refraction plate 410 having a spherical surface facing the transducer and a refracting surface with refracting pyramid elements 450 facing the subject causes the ultrasound beam to impinge on a plurality of overlapping focal regions and thereby expand the focal area of the transducer. In a second embodiment the refraction plate comprises a phased lens 600 having a constant thickness at any angular location but with its thickness varying linearly over 2.pi. radians or multiples thereof.
    Type: Grant
    Filed: March 17, 1997
    Date of Patent: February 23, 1999
    Assignee: General Electric Company
    Inventors: Harvey Ellis Cline, Ronald Dean Watkins, George Raymond Russell, Kullervo Henrik Hynynen