Abstract: Medical devices for implantation in a body vessel are provided. A medical device can be configured as a drainage stent adapted for placement in a bodily passageway. The drainage stent preferably includes a drainage lumen extending longitudinally through the drainage stent, and a sleeve defining a collapsible lumen in fluid flow communication with the drainage lumen. The sleeve may function as a one-way valve and preferably includes a biodeposition-reducing bioactive agent, such as an antibiotic or antimicrobial agent. The medical device may be configured as a biliary or pancreatic stent.

Abstract: A method of removing an obstruction in the biliary duct including the steps of providing a coaxial catheter device comprising an inner catheter having a proximal end and a distal end wherein at least two or more lumens are formed between the proximal end and distal end of the inner catheter. The method includes providing an outer catheter having a proximal end and a distal end and an opening wherein the inner catheter is coaxially engaged through the opening of the outer catheter thereby forming a coaxial space between the inner catheter and the outer catheter wherein at least one of the two or more lumens is configured for receiving a fluid for inflating a balloon, at least one of the first lumen and the second lumen is configured for receiving a wire guide and the coaxial space is configured for receiving a flushing fluid for the removal of an obstruction within the biliary duct.

Abstract: Disclosed is a pressure sensitive prosthesis that includes a tubular member having a passageway extending therethrough and a sleeve attached about one end of the tubular member. The sleeve functions as a one-way valve to permit fluid flowing through the sleeve lumen in a first, distal direction and under a first pressure, while collapsing in response to fluid flowing in a second direction when the pressure thereof exceeds that of the first direction or pressure. One aspect of the invention includes an esophageal anti-reflux expandable prosthesis wherein the sleeve is adapted to invert out of the tubular stent frame to permit belching or vomiting (fluid or materials under a third, higher pressure).