Abstract: The present disclosure provides a closed-loop DBS system and method for regulating motor symptoms of a subject. The DBS system comprises: neural electrodes for being implanted in deep brain nuclei of the subject and a closed-loop stimulation generator in communication with the neural electrodes. The stimulation generator includes: a data acquisition unit configured to receive the LFP signals transmitted from the neural electrodes and convert the LFP signals to LFP data; a processing unit in communication configured to analyze the LFP data to determine presence of abnormal beta band oscillation and generate a DBS signal upon determining presence of abnormal beta band oscillation; and a pulse generation unit configured to generate, in response to the DBS signal, the DBS pulses to the deep brain nuclei through the neural electrodes. The provided system and method can save stimulation time and avoid adverse side effects of continuous stimulation while maintaining treatment efficacy.