Patents by Inventor Kumar Kamlesh SINGH

Kumar Kamlesh SINGH has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR THE PREPARATION OF MIRABEGRON FREE FROM GENOTOXIC IMPURITIES
    Publication number: 20250051295
    Abstract: The present invention relates to mirabegron substantially free from genotoxic impurities particularly nitrosamine impurities of Formula (I), (II), (III), (IV), (V) and processes for its preparation. In particular, the invention relates to processes for the preparation of high purity mirabegron free from nitrosamine impurities of Formula (I), (II), (III), (IV), (V) and other genotoxic and carcinogenic impurities below threshold concentration.
    Type: Application
    Filed: August 7, 2024
    Publication date: February 13, 2025
    Inventors: Kumar Kamlesh SINGH, Kuldeep Natwarlal Jain, Naitik Bharatbhai Patel, Hemantkumar Jagatpal Singh, Pratik Jayantibhai Nariya
  • NEW PROCESS FOR PREPARATION OF AFICAMTEN
    Publication number: 20250034095
    Abstract: The present disclosure provides a new process for preparation of Aficamten. The present disclosure also provides t a novel intermediate compound or a salt, isomer or mixture thereof. Further, the present disclosure also provides a process for preparation of novel intermediate compound or a salt, an isomer or a mixture thereof. Furthermore, the provides a method of using of novel intermediate compound for preparation of Aficamten.
    Type: Application
    Filed: July 9, 2024
    Publication date: January 30, 2025
    Inventors: Kumar Kamlesh Singh, Jitesh Amratlal Desai, Chirag Jayantilal Vyas, Jaydev Rameshchandra Vaghela
  • Composition comprising high purity pyrrole derivative and method for preparation thereof
    Patent number: 12201611
    Abstract: The present invention relates to a composition comprising high purity pyrrole derivative and method for preparation thereof. The present invention particularly relates to compositions comprising Saroglitazar magnesium having purity of 99.0% or more, and one or more of an aldehyde compound of Formula (II), diketo oxirane compound of Formula (III), hydroxy methyl compound of Formula (IV) or dimer compound of Formula (V), relative to saroglitazar magnesium, each present in an amount of about 0.15% or less, respectively, by weight, when measured by area percentage of HPLC.
    Type: Grant
    Filed: July 23, 2021
    Date of Patent: January 21, 2025
    Assignee: Zydus Lifesciences Limited
    Inventors: Kumar Kamlesh Singh, Sanjay Jagdish Desai, Piyush Rajendra Sharma, Daya Ram Pal, Sanjeev Kumar Tripathi, Mayur Ramnikbhai Patel
  • AMORPHOUS FORM OF RESMETIROM AND PROCESS FOR PREPARATION THEREOF
    Publication number: 20240423993
    Abstract: The present invention relates to an amorphous form of resmetirom. In particular, the present invention relates to an amorphous solid dispersion of resmetirom. The present invention relates to processes for the preparation of amorphous form of resmetirom. The present invention also relates to processes for the preparation of amorphous solid dispersion of resmetirom.
    Type: Application
    Filed: June 24, 2024
    Publication date: December 26, 2024
    Inventors: Kumar Kamlesh SINGH, Kuldeep Natwarlal JAIN, Naitik Bharatbhai PATEL, Keval Ramnikbhai BAMBHAROLIYA
  • DESIDUSTAT PARTICLES AND COMPOSITIONS THEREOF
    Publication number: 20240408022
    Abstract: This invention relates to a field of pharmaceuticals, in particular to desidustat particles having specific particle size distribution and pharmaceutical compositions thereof.
    Type: Application
    Filed: September 19, 2022
    Publication date: December 12, 2024
    Inventors: Kumar Kamlesh SINGH, Kannan Essakimuthu MUTHAIYYAN, Ritu Nitin LADDHA, Santosh Devidas DIWAKAR, Mukeshkumar Hirabhai UKAWALA, Chintan Sureshbhai DHOLAKIA, Jitendrakumar Dashrathial PATEL, Sumer Singh CHUNDAWAT
  • AN AMORPHOUS SOLID DISPERSION OF A QUINOLONE COMPOUND AND PROCESS FOR THE PREPARATION THEREOF
    Publication number: 20240358643
    Abstract: The invention relates to an amorphous solid dispersion of a quinolone compound of Formula I and process for the preparation thereof.
    Type: Application
    Filed: August 26, 2022
    Publication date: October 31, 2024
    Inventors: Kumar Kamlesh SINGH, Santosh Devidas DIWAKAR, Sumer Singh CHUNDAWAT, Jayesh Anilkumar SHARMA, Ankit Nanjibhai JALELA, Chintan DHOLAKIA
  • PROCESS FOR THE PREPARATION OF SITAGLIPTIN FREE FROM GENOTOXIC IMPURITIES
    Publication number: 20240316041
    Abstract: The present invention relates to sitagliptin or a pharmaceutically acceptable salt thereof substantially free from genotoxic impurities particularly nitrosamine impurities and processes for its preparation. In particular, the invention relates to process for the preparation of high purity sitagliptin free from nitrosamine impurities and other genotoxic and carcinogenic impurities below threshold concentration.
    Type: Application
    Filed: March 4, 2024
    Publication date: September 26, 2024
    Inventors: Kumar Kamlesh SINGH, Santosh Devidas DIWAKAR, Chintan Sureshbhai DHOLAKIA, Abhishek Kumar LAL, Dayawant Bhimsing RATHOD, Hitesh Phulchandbhai THUMBAR
  • A QUINOLONE COMPOUND IN SOLID FORMS AND PROCESSES FOR THE PREPARATION THEREOF
    Publication number: 20240300899
    Abstract: The present invention relates to novel crystalline forms of a quinolone compound of Formula (I). The invention also relates to processes for the preparation crystalline forms of the compound of Formula (I). Further the disclosure provides a process for the preparation of compound of Formula (I), intermediates, impurities and pharmaceutical compositions thereof.
    Type: Application
    Filed: March 17, 2022
    Publication date: September 12, 2024
    Inventors: Kumar Kamlesh SINGH, Rajiv SHARMA, Santosh Devidas DIWAKAR, Jitendra Maganbhai GAJERA, Sumer Singh CHUNDAWAT, Jayesh Anilkumar SHARMA
  • Process for preparation of isoxazoline substituted benzamide compound
    Patent number: 12065414
    Abstract: The invention relates to process for the preparation of isoxazoline-substituted benzamide compound and intermediates thereof. The invention also relates to process for the preparation of Fluralaner and intermediates thereof.
    Type: Grant
    Filed: September 2, 2021
    Date of Patent: August 20, 2024
    Assignee: ZYDUS LIFESCIENCES LIMITED
    Inventors: Kumar Kamlesh Singh, Sanjay Jagdish Desai, Kuldeep Natwarlal Jain, Jitesh Amratlal Desai, Sarvil Dhirajbhai Patel
  • PROCESS FOR PREPARATION OF MIDODRINE AND INTERMEDIATES THEREOF
    Publication number: 20220144754
    Abstract: The invention relates to process for the preparation of midodrine or pharmaceutically acceptable salts thereof. The invention also relates to process for the preparation of intermediates of midodrine.
    Type: Application
    Filed: November 10, 2021
    Publication date: May 12, 2022
    Inventors: Kumar Kamlesh Singh, Sanjay Jagdish Desai, Tadikonda Pratap V., Mahesh Laljibhai Rupapara
  • PROCESS FOR PREPARATION OF ISOXAZOLINE SUBSTITUTED BENZAMIDE COMPOUND
    Publication number: 20220064130
    Abstract: The invention relates to process for the preparation of isoxazoline-substituted benzamide compound and intermediates thereof. The invention also relates to process for the preparation of Fluralaner and intermediates thereof.
    Type: Application
    Filed: September 2, 2021
    Publication date: March 3, 2022
    Inventors: Kumar Kamlesh SINGH, Sanjay Jagdish DESAI, Kuldeep Natwarlal JAIN, Jitesh Amratlal DESAI, Sarvil Dhirajbhai PATEL
  • Process for preparation of grapiprant
    Patent number: 11254675
    Abstract: The invention relates to process for the preparation of grapiprant and its intermediates thereof. The invention also relates to grapiprant having a purity 98% or more and compounds of Formula (A), (B), (C) and (D) in an amount of 0.5 or less, relative to grapiprant, by area percentage of HPLC. The invention also relates to an amorphous form of grapiprant and process for preparation thereof.
    Type: Grant
    Filed: August 12, 2020
    Date of Patent: February 22, 2022
    Assignee: CADILA HEALTHCARE LIMITED
    Inventors: Kumar Kamlesh Singh, Jitendra Maganbhai Gajera, Sumer Singh Chundavat, Dipak Ambalal Patel
  • COMPOSITION COMPRISING HIGH PURITY PYRROLE DERIVATIVE AND METHOD FOR PREPARATION THEREOF
    Publication number: 20220023262
    Abstract: The present invention relates to a composition comprising high purity pyrrole derivative and method for preparation thereof. The present invention particularly relates to compositions comprising Saroglitazar magnesium having purity of 99.0% or more, and one or more of an aldehyde compound of Formula (II), diketo oxirane compound of Formula (III), hydroxy methyl compound of Formula (IV) or dimer compound of Formula (V), relative to saroglitazar magnesium, each present in an amount of about 0.15% or less, respectively, by weight, when measured by area percentage of HPLC.
    Type: Application
    Filed: July 23, 2021
    Publication date: January 27, 2022
    Inventors: Kumar Kamlesh SINGH, Sanjay Jagdish DESAI, Piyush Rajendra SHARMA, Daya Ram PAL, Sanjeev Kumar TRIPATHI, Mayur Ramnikbhai PATEL
  • PROCESS FOR PREPARATION OF GRAPIPRANT
    Publication number: 20210347776
    Abstract: The invention relates to process for the preparation of grapiprant and its intermediates thereof. The invention also relates to grapiprant having a purity 98% or more and compounds of Formula (A), (B), (C) and (D) in an amount of 0.5 or less, relative to grapiprant, by area percentage of HPLC. The invention also relates to an amorphous form of grapiprant and process for preparation thereof.
    Type: Application
    Filed: July 23, 2021
    Publication date: November 11, 2021
    Applicant: CADILA HEALTHCARE LIMITED
    Inventors: Kumar Kamlesh SINGH, Jitendra Maganbhai GAJERA, Sumer Singh CHUNDAVAT, Dipak Ambalal PATEL
  • PROCESS FOR PREPARATION OF FOSNETUPITANT
    Publication number: 20210214306
    Abstract: The present invention relates to a process for the preparation of fosnetupitant. The invention further relates to an amorphous fosnetupitant chloride hydrochloride and process for the preparation thereof.
    Type: Application
    Filed: January 13, 2021
    Publication date: July 15, 2021
    Applicant: CADILA HEALTHCARE LIMITED
    Inventors: Kumar Kamlesh SINGH, Sanjay Jagdish DESAI, Jagdish Maganbhai PATEL, Chirag Jayantilal VYAS, Dhaval Jashwantlal SOLANKI, Sudhir Ganpatbhai DHANANI
  • PROCESS FOR PREPARATION OF GRAPIPRANT
    Publication number: 20210079000
    Abstract: The invention relates to process for the preparation of grapiprant and its intermediates thereof. The invention also relates to grapiprant having a purity 98% or more and compounds of Formula (A), (B), (C) and (D) in an amount of 0.5 or less, relative to grapiprant, by area percentage of HPLC. The invention also relates to an amorphous form of grapiprant and process for preparation thereof.
    Type: Application
    Filed: August 12, 2020
    Publication date: March 18, 2021
    Applicant: CADILA HEALTHCARE LIMITED
    Inventors: Kumar Kamlesh SINGH, Jitendra Maganbhai GAJERA, Sumer Singh CHUNDAVAT, Dipak Ambalal PATEL
  • Process for preparation of apalutamide
    Patent number: 10934269
    Abstract: The present invention relates to a process for the preparation of apalutamide. In particular, the present invention relates to a process for the preparation of apalutamide and its intermediates. The present invention also relates to pharmaceutical compositions comprising apalutamide.
    Type: Grant
    Filed: September 27, 2019
    Date of Patent: March 2, 2021
    Assignee: CADILA HEALTHCARE LIMITED
    Inventors: Kumar Kamlesh Singh, Nikhil Amar Singh, Ganpatdan Shimbhu Charan, Nimeshkumar Mukeshkumar Shah
  • AMORPHOUS ERTUGLIFLOZIN AND PROCESS FOR ITS PREPARATION
    Publication number: 20200376017
    Abstract: An amorphous form of ertugliflozin and process for its preparation is described. A solid form of ertugliflozin and process for preparation thereof is also described.
    Type: Application
    Filed: May 29, 2020
    Publication date: December 3, 2020
    Applicant: CADILA HEALTHCARE LIMITED
    Inventors: Sanjay Jagdish DESAI, Tadikonda PRATAP V., Mahesh Laljibhai RUPAPARA, Kumar Kamlesh SINGH, Hardik Bhikhubhai GHODASARA
  • Process for preparation of apalutamide
    Patent number: 10807965
    Abstract: The present invention relates to a process for the preparation of apalutamide. In particular, the present invention relates to a process for the preparation of apalutamide and its intermediates. The present invention also relates to pharmaceutical compositions comprising apalutamide.
    Type: Grant
    Filed: March 27, 2019
    Date of Patent: October 20, 2020
    Assignee: CADILA HEALTHCARE LIMITED
    Inventors: Kumar Kamlesh Singh, Nikhil Amar Singh, Ganpat Dan Shimbhu Charan, Nimeshkumar Mukeshkumar Shah
  • A PROCESS FOR PREPARATION OF TRIAMINOPYRIMIDINE COMPOUND AND INTERMEDIATES THEREOF
    Publication number: 20200207738
    Abstract: The present invention relates to triaminopyrimidine compound 1, or pharmaceutically acceptable salts thereof, or hydrates, or solvates, or polymorphs, or optically active forms thereof, in solid state forms. The invention also relates to a process for preparation of triaminopyrimidine compound and intermediates thereof. The present invention also relates to a pharmaceutical composition comprising pure triaminopyrimidine compound, useful for preventing or treating malaria.
    Type: Application
    Filed: September 4, 2018
    Publication date: July 2, 2020
    Inventors: Kumar Kamlesh SINGH, Nikhil Amar SINGH, Ganapatdan Shimbhu CHARAN, Nimeshkumar Mukeshkumar SHAH, Sunil Dnyaneshwar NARODE, Dipakkumar Dhanjibhai VACHHANI, Amol Kashinath PATIL, Sandip Pundlik KHAIRNAR