Abstract: Methods and apparatus for reducing particle generation in a remote plasma source (RPS) include an RPS having a first plasma source with a first electrode and a second electrode, wherein the first electrode and the second electrode are symmetrical with hollow cavities configured to induce a hollow cathode effect within the hollow cavities, and wherein the RPS provides radicals or ions into the processing volume, and a radio frequency (RF) power source configured to provide a symmetrical driving waveform on the first electrode and the second electrode to produce an anodic cycle and a cathodic cycle of the RPS, wherein the anodic cycle and the cathodic cycle operate in a hollow cathode effect mode.

Abstract: A refilling device for an article of an aerosol provision system comprises refilling control circuitry configured to facilitate the transfer of aerosol-generating material from a reservoir to the article in response to detecting that the article has been received by the refilling device.

Abstract: Described herein are HSP-90 inhibitors conjugated to lipids, compositions comprising the conjugates, and methods of use thereof for treating cancer.

Abstract: A desktop refilling device for an article of an aerosol provision system comprising the article and an aerosol provision device. The desktop refilling device comprises an article interface configured to receive the article when the article is separated from the aerosol provision device, and refilling control circuitry configured to facilitate the transfer of aerosol-generating material from a reservoir couplable to the refilling device to the article.

Abstract: A desktop refilling device for an article of an aerosol provision system comprises an article interface configured to receive the article, a reservoir interface configured to receive a reservoir, and refilling control circuitry configured to facilitate the transfer of aerosol-generating material from the reservoir to the article, wherein the article interface and/or the reservoir interface are configured to respectively enclose the article and the reservoir inside a housing of the desktop refilling device during the transfer of aerosol-generating material from the reservoir to the article.

Abstract: A system receives identification of a machine learning model, stored by a vehicle, that is ready for training. The system determines, based on a configuration file associated with the model, whether batch-based or live training is to be used to train the model and collects data for training, defined by a configuration file associated with the model. The system calls a learning as a service vehicle process to load a kernel and configures the kernel based on configuration data defined in the configuration file. The system receives notification from the learning as a service process that the training is complete. Additionally, the system validates a model, responsive to the notification including indication that training was successful, using a vehicle model validation process to test the model with live data before deployment by background execution of the model and saves a copy of the model for deployment responsive to successful validation.

Abstract: A system receives identification of data to be gathered, via a request configured based on a configuration file associated with a machine learning model stored by a vehicle. The system receives identification of how the data is to be labeled, defined by the configuration file and create one or more topics for publication of the data, onboard the vehicle, the publication including both the gathered data and any meta-data usable to label the data in accordance with the definitions in the configuration file. Also, the system subscribes to the topics to receive the published data and the metadata and appends labels to the data, using the metadata, to label the data in accordance with the definitions for labeling in the configuration file. The system saves the labeled data in vehicle memory as data associated with the model.

Abstract: The invention relates to an autoinjector 59 for administering a fluid medicament to a subject comprising: a housing 1 for receiving a cartridge holder; a driver assembly 8; the driver assembly on actuation may move the cartridge 3 forward in the cartridge holder 2; a needle cover 4 may be coupled to the housing wherein the needle cover 4 travels in a linear or translational movement; said needle cover 4 is adapted to protect a needle when the needle cover may be in first locking position 17 and second locking position 18; the linear or translational movement may be achieved by a cam profile 13 and a cam follower 14; the cam profile 13 may be provided on outside surface of housing and the cam follower 14 located between the needle cover 4 and the housing 1; a first biasing member 15; and a second biasing member 16 configured to bias the cartridge 3 and the needle cover 4 respectively; and a safety cap 11 to control the actuation of the autoinjector.

Abstract: Methods and apparatus for reducing particle generation in a remote plasma source (RPS) include an RPS having a first plasma source with a first electrode and a second electrode, wherein the first electrode and the second electrode are symmetrical with hollow cavities configured to induce a hollow cathode effect within the hollow cavities, and wherein the RPS provides radicals or ions into the processing volume, and a radio frequency (RF) power source configured to provide a symmetrical driving waveform on the first electrode and the second electrode to produce an anodic cycle and a cathodic cycle of the RPS, wherein the anodic cycle and the cathodic cycle operate in a hollow cathode effect mode.

Abstract: A dispensing device is provided to dispense a designated amount of a material on every dose delivery operation. The dispensing device includes a thumb pad, a cam drum coupled to the thumb pad, and a pawl nut comprising a one-way pawl. The thumb pad may be pulled out in a direction away from a distal end of the dispensing device for setting a dose of the material to be dispensed out and may be pushed in towards the distal end for delivering the dose. The cam drum includes a plurality of linear cam profiles and a plurality of helical cam profiles that may be disposed on a surface of the cam drum. The one-way pawl may engage with a ratchet disposed at a distal end of the cam drum and may prevent a rotation of the cam drum in an undesired direction.

Abstract: A safety housing based implant/medicament injecting system. System includes a needle assembly prefilled implant/medicament for injection and an injecting needle/cannula, a housing for accommodating the needle assembly under usual bias inside said housing, a plunger means having a plunger rod configured for stage wise forward motion including an initial injecting plunger forward motion with the needle assembly within the housing to first engage the needle assembly with the housing and subsequent continuing injecting plunger forward motion independent of the needle assembly for injecting of the implant/medicament, and post injecting return of the needle assembly secured inside said housing blocking any subsequent use thereof.

Abstract: Methods and apparatus for reducing particle generation in a remote plasma source (RPS) include an RPS having a first plasma source with a first electrode and a second electrode, wherein the first electrode and the second electrode are symmetrical with hollow cavities configured to induce a hollow cathode effect within the hollow cavities, and wherein the RPS provides radicals or ions into the processing volume, and a radio frequency (RF) power source configured to provide a symmetrical driving waveform on the first electrode and the second electrode to produce an anodic cycle and a cathodic cycle of the RPS, wherein the anodic cycle and the cathodic cycle operate in a hollow cathode effect mode.

Abstract: A safety housing based implant/medicament injecting system. System includes a needle assembly prefilled implant/medicament for injection and an injecting needle/cannula, a housing for accommodating the needle assembly under usual bias inside said housing, a plunger means having a plunger rod configured for stage wise forward motion including an initial injecting plunger forward motion with the needle assembly within the housing to first engage the needle assembly with the housing and subsequent continuing injecting plunger forward motion independent of the needle assembly for injecting of the implant/medicament, and post injecting return of the needle assembly secured inside said housing blocking any subsequent use thereof.

Abstract: A safety housing based implant/medicament injecting system. System includes a needle assembly prefilled implant/medicament for injection and an injecting needle/cannula, a housing for accommodating the needle assembly under usual bias inside said housing, a plunger means having a plunger rod configured for stage wise forward motion including an initial injecting plunger forward motion with the needle assembly within the housing to first engage the needle assembly with the housing and subsequent continuing injecting plunger forward motion independent of the needle assembly for injecting of the implant/medicament, and post injecting return of the needle assembly secured inside said housing blocking any subsequent use thereof.

Abstract: A safety housing based implant/medicament injecting system. System includes a needle assembly prefilled implant/medicament for injection and an injecting needle/cannula, a housing for accommodating the needle assembly under usual bias inside said housing, a plunger means having a plunger rod configured for stage wise forward motion including an initial injecting plunger forward motion with the needle assembly within the housing to first engage the needle assembly with the housing and subsequent continuing injecting plunger forward motion independent of the needle assembly for injecting of the implant/medicament, and post injecting return of the needle assembly secured inside said housing blocking any subsequent use thereof.

Abstract: Methods and apparatus for reducing particle generation in a remote plasma source (RPS) include an RPS having a first plasma source with a first electrode and a second electrode, wherein the first electrode and the second electrode are symmetrical with hollow cavities configured to induce a hollow cathode effect within the hollow cavities, and wherein the RPS provides radicals or ions into the processing volume, and a radio frequency (RF) power source configured to provide a symmetrical driving waveform on the first electrode and the second electrode to produce an anodic cycle and a cathodic cycle of the RPS, wherein the anodic cycle and the cathodic cycle operate in a hollow cathode effect mode.

Abstract: A method and a voice assistant device for managing private data are provided. The voice assistant device includes a processor configured to detect a privacy triggering event while obtaining at least one voice input from a first user in a voice input mode, switch from the voice input mode to a non-voice input mode in response to the privacy triggering event, obtain a non-voice input from the first user in the non-voice input mode, and execute an operation of the voice assistant device corresponding to the non-voice input.

Abstract: The invention relates to an autoinjector 59 for administering a fluid medicament to a subject comprising: a housing 1 for receiving a cartridge holder; a driver assembly 8; the driver assembly on actuation may move the cartridge 3 forward in the cartridge holder 2; a needle cover 4 may be coupled to the housing wherein the needle cover 4 travels in a linear or translational movement; said needle cover 4 is adapted to protect a needle when the needle cover may be in first locking position 17 and second locking position 18; the linear or translational movement may be achieved by a cam profile 13 and a cam follower 14; the cam profile 13 may be provided on outside surface of housing and the cam follower 14 located between the needle cover 4 and the housing 1; a first biasing member 15; and a second biasing member 16 configured to bias the cartridge 3 and the needle cover 4 respectively; and a safety cap 11 to control the actuation of the autoinjector.

Abstract: The present invention provides a process for the preparation of vigabatrin of formula (I) comprising of dissolving vigabatrin in water, optionally treating with charcoal, filtering and adding an acid to the reaction mass followed by the addition of an organic solvent and then isolating vigabatrin of formula (I) with high purity.

Abstract: A dispensing device (102) is provided to dispense a designated amount of material on every dose delivery operation. The dispensing device (102) includes a thumb pad (202) and a cam drum (204) that is coupled to the thumb pad (202). The thumb pad (202) is configured to be pulled out towards a proximal end (104) of the dispensing device (102) for setting a dose of a material to be dispensed out and to be pushed in towards a distal end (106) of the dispensing device (102) for delivering the dose. The cam drum (204) includes at least one linear cam profile (402) and at least one helical cam profile (404) that are disposed on a surface of the cam drum (204). The thumb pad (202) is configured to ride on the linear cam profile (402) when setting the dose and on the helical cam profile (404) when delivering the dose.