Patents by Inventor Kumar Nikunj

Kumar Nikunj has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR THE PREPARATION OF IMMOBILIZED RECOMBINANT PENICILLIN ACYLASE CATALYST FROM ACHROMOBACTER SP. CCM 4824 EXPRESSED IN E. COLI BL 21 CCM 7394 AND ITS USE FOR THE SYNTHESIS OF BETA-LACTAM ANTIBIOTICS
    Publication number: 20100190206
    Abstract: The present invention discloses isolation of Penicillin Acylase (PA) from Achromobacter sp CCM 4824 expressed in recombinant strain E. coli BL21 CCM 7394 bearing the recombinant plasmid pKXIP1 and processing of PA into biocatalyst useful for the industrial synthesis of antibiotics. More particularly the invention discloses a synthesis of semi-synthetic ?-lactam antibiotics in the reaction mixture consisting of activated acyl-donor (D-p-hydroxyphenylglycine methyl ester or amide for Amoxicillin and Cefadroxil; D-phenylglycine methyl ester or amide for Ampicillin and Cephalexin) and nucleophile (6-APA or 7-ADCA) catalyzed by PA obtained from recombinant E. coli BL21 CCM 7394 as the biocatalyst.
    Type: Application
    Filed: July 27, 2007
    Publication date: July 29, 2010
    Inventors: Anupama Datla, Vyasarayani Williams Rajasekar, Pavel Kyslik, Stanislav Becka, Ashar Trupti Krishnakant, Zambre Sujata Yogesh, Kumar Nikunj