Abstract: The present application provides materials and methods for treating a patient with one or more conditions associated with ANGPTL3 whether ex vivo or in vivo. In addition, the present application provides materials and methods for editing and/or modulating the expression of ANGPTL3 gene in a cell by genome editing.

Abstract: A system is provided for automatically generating electronic artifacts using extended functionality. In particular, the system may use a template-based process to automatically generate artifacts based on a defined set of parameters and/or variables. The system may further use one or more plugins which may provide extended functionality with respect to the artifact generation process. Accordingly, the artifact generation process may include initializing a parameter list based on application parameters and/or plugin parameters, processing the parameters, generating variables based on the parameters, and replacing variables in scheme template files with appropriate values (e.g., user supplied or plugin generated values) to output an artifact file to a predetermined location. In this way, the system provides a robust and efficient way to automatically generate artifacts.

Abstract: The present application provides materials and methods for treating a patient with one or more conditions associated with SCN10A whether ex vivo or in vivo. In addition, the present application provides materials and methods for editing and/or modulating the expression of SCN10A gene in a cell by genome editing.

Abstract: The present application provides materials and methods for treating a patient with Amyotrophic Lateral Sclerosis (ALS). In addition, the present application provides materials and methods for (1) modifying the transcription start site of exon1a to render the transcription start site non-functioning, (2) deleting the transcription site of exon1a, (3) deleting exon1a, or (4) deleting of the expanded hexanucleotide repeat within or near the C9ORF72 gene, or any combinations of (1)-(4), above in a cell by genome editing.

Abstract: The present application provides materials and methods for treating a patient with one or more conditions associated with SCN10A whether ex vivo or in vivo. In addition, the present application provides materials and methods for editing and/or modulating the expression of SCN10A gene in a cell by genome editing.

Abstract: The present application provides materials and methods for treating a patient with one or more condition associated with FXN whether ex vivo or in vivo. In addition, the present application provides materials and methods for editing and/or modulating the expression of FXN gene in a cell by genome editing.

Abstract: The present application provides materials and methods for treating a patient with one or more conditions associated with SCN9A whether ex vivo or in vivo. In addition, the present application provides materials and methods for editing and/or modulating the expression of SCN9A gene in a cell by genome editing.

Abstract: The present application provides materials and methods for treating a patient with one or more conditions associated with DMPK whether ex vivo or in vivo. In addition, the present application provides materials and methods for editing and/or modulating the expression of DMPK gene in a cell by genome editing.

Abstract: A system for assisting users in listing items for sale in an electronic marketplace is disclosed. A video is received from a user device associated with a user, the video including a video stream depicting a plurality of items to be listed for sale in the electronic marketplace. Respective images depicting respective items among the plurality of items are obtained from the video stream, and respective attributes of the respective items among the plurality of items are extracted from the video. Respective listings for sale of the respective items are generated based at least in part on the respective attributes of the respective items among the plurality of items, and the respective listings for sale of the respective items are displayed to the user.

Abstract: A cable connector includes a slide coupled to a spring to bias the slide from a retracted position to an extended position and at least one latch coupled to the slide. The slide, when in the extended position, is configured to rotate the at least one latch to secure the at least one latch, and when in the retracted position, is configured to rotate the at least one latch in an opposite direction to release the at least one latch. The slide is configured to engage a contact switch when securing the at least one latch.

Abstract: The present application provides materials and methods for treating a patient with one or more condition associated with FXN whether ex vivo or in vivo. In addition, the present application provides materials and methods for editing and/or modulating the expression of FXN gene in a cell by genome editing.

Abstract: The present disclosure provides materials and methods for treating a patient with one or more conditions or disorders associated with ATXN1 whether ex vivo or in vivo. For example, the present disclosure provides materials and methods for treating a patient with Spinocerebellar ataxia type 1 (SCA1). Also provided are materials and methods for editing a ATXN1 gene in a cell by genome editing. The present disclosure also provides materials and methods for altering the contiguous genomic sequence of a ATXN1 gene in a cell. In addition, the present disclosure provides one or more gRNAs for editing a ATXN1 gene. Also provided are therapeutics comprising at least one or more gRNAs for editing a ATXN1 gene. In addition, the present disclosure provides therapeutics for treating patients with a ATXN1 related condition or disorder.

Abstract: A first test case identifier that indicates a first test case is received. The first test case is indicative of testing one or more features of an application associated with the electronic marketplace. The first test case identifier is compared to a plurality of attributes. The plurality of attributes are associated with one or more listings that describe one or more items for sale in an electronic marketplace. Based at least in part on the comparing, it is determined that a first set of attributes, of the plurality of attributes, are test data candidates to be used as input to the first test case. Based at least in part on the determining, the first test case is caused to be run using at least one of the first set of attributes as test data for input.

Abstract: Various methods and systems for providing predicted item conditions for items in an item listing system. A predicted item condition may indicate a calculated estimate of a descriptive state of the item based on item transaction features. Operationally, item transaction features of an item—associated with an item listing interface—are accessed at the item listing system. The item transaction features are communicated to an item condition prediction machine learning model of the item listing system. The item condition machine learning model is trained on historical item transactions comprising item condition features of historical item transactions, the historical item transactions are previous item transactions associated with the item listing system. Based on the item transaction features of the item, the item condition machine learning model is caused to generate a predicted item condition. The predicted item condition is communicated as a recommended item condition or required item condition.

Abstract: Various methods and systems for providing customized-item-specific interfaces of items on extended interface devices in a search system. A plurality of items—each having an extended interface configuration that indicates customized-item-specific interface instructions for extended presentation of items on extended interface devices—are accessed at a primary interface device associated with a set of extended interface devices including a second-user extended interface device that supports a social mode. Based on the first extended interface configuration of a first item, a determination is made that the first item is extendable to a first extended interface device in the set of extended interface devices. Based on determining that the first item is extendable, automatically causing generation of a customized-item-specific interface of the first item on the first extended interface device.

Abstract: The present application provides materials and methods for treating a patient with one or more conditions associated with ANGPTL4 whether ex vivo or in vivo. In addition, the present application provides materials and methods for editing and/or modulating the expression of ANGPTL4 gene in a cell by genome editing.

Abstract: The present application provides materials and methods for treating a patient with one or more conditions associated with APOCIII whether ex vivo or in vivo. In addition, the present application provides materials and methods for editing and/or modulating the expression of APOCIII gene in a cell by genome editing.

Abstract: The present application provides materials and methods for treating a patient with one or more conditions associated with SCN9A whether ex vivo or in vivo. In addition, the present application provides materials and methods for editing and/or modulating the expression of SCN9A gene in a cell by genome editing.

Abstract: The present application provides materials and methods for treating a patient with Amyotrophic Lateral Sclerosis (ALS). In addition, the present application provides materials and methods for (1) modifying the transcription start site of exon1a to render the transcription start site non-functioning, (2) deleting the transcription site of exon1a, (3) deleting exon1a, or (4) deleting of the expanded hexanucleotide repeat within or near the C9ORF72 gene, or any combinations of (1)-(4), above in a cell by genome editing.

Abstract: The present application provides materials and methods for treating a patient with one or more conditions associated with DMPK whether ex vivo or in vivo. In addition, the present application provides materials and methods for editing and/or modulating the expression of DMPK gene in a cell by genome editing.